Prognostic significance of lactate clearance in severe acute pancreatitis

Betül Çiğdem Yortanlı; Korhan Kollu; Burcu Kuş; Ekrem Taha Sert; Mehmet Yortanlı

Makale detayları

Prognostic significance of lactate clearance in severe acute pancreatitis

Yazarlar:

Betül Çiğdem Yortanlı | Korhan Kollu | Burcu Kuş | Ekrem Taha Sert | Mehmet Yortanlı

Yayıncı:

Cukurova University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji | İç Hastalıkları | Yoğun Bakım

Dergi:

Cukurova Medical Journal Vol.50 Issue 2, pp.450-459

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001351461

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: This study aimed to evaluate the prognostic value of lactate clearance in predicting severe acute pancreatitis SAP in patients with acute pancreatitis AP. Identifying early biomarkers for SAP can help in risk stratification and guide clinical management. Materials and Methods: This retrospective, single-center observational study included 183 patients diagnosed with AP between January 2022 and January 2023. Patients were classified as SAP or non-SAP based on the 2012 Atlanta Classification. Demographic data, laboratory parameters, and clinical outcomes were analyzed. Lactate clearance was calculated as initial lactate  24-hour lactateinitial lactate  100.. Results: Among 183 patients, 105 57.4 had SAP. SAP patients had significantly longer hospital stays, higher intensive care unit admissions, and increased mortality rates. SAP patients had significantly higher initial and 24-hour lactate levels but lower lactate clearance. Lower lactate clearance was an independent predictor of SAP OR: 3.051, 95 CI: 2.0305.072, p0.001. ROC analysis revealed that lactate clearance had an AUC of 0.835 95 CI: 0.7760.894, with 81.9 sensitivity and 76.9 specificity at a cutoff value of 40.9. Conclusion: Low lactate clearance is strongly associated with SAP development, longer hospitalization, ICU need, and increased mortality. Lactate clearance may serve as a valuable early prognostic marker. Future studies should explore integrating lactate clearance with markers such as SII, SIIalbumin ratio, and RDW to enhance risk stratification and clinical decision-making in AP.

 Purpose: This study aimed to evaluate the prognostic value of lactate clearance in predicting severe acute pancreatitis SAP in patients with acute pancreatitis AP. Identifying early biomarkers for SAP can help in risk stratification and guide clinical management. Materials and Methods: This retrospective, single-center observational study included 183 patients diagnosed with AP between January 2022 and January 2023. Patients were classified as SAP or non-SAP based on the 2012 Atlanta Classification. Demographic data, laboratory parameters, and clinical outcomes were analyzed. Lactate clearance was calculated as initial lactate  24-hour lactateinitial lactate  100.. Results: Among 183 patients, 105 57.4 had SAP. SAP patients had significantly longer hospital stays, higher intensive care unit admissions, and increased mortality rates. SAP patients had significantly higher initial and 24-hour lactate levels but lower lactate clearance. Lower lactate clearance was an independent predictor of SAP OR: 3.051, 95 CI: 2.0305.072, p0.001. ROC analysis revealed that lactate clearance had an AUC of 0.835 95 CI: 0.7760.894, with 81.9 sensitivity and 76.9 specificity at a cutoff value of 40.9. Conclusion: Low lactate clearance is strongly associated with SAP development, longer hospitalization, ICU need, and increased mortality. Lactate clearance may serve as a valuable early prognostic marker. Future studies should explore integrating lactate clearance with markers such as SII, SIIalbumin ratio, and RDW to enhance risk stratification and clinical decision-making in AP.

 Purpose: This study aimed to evaluate the prognostic value of lactate clearance in predicting severe acute pancreatitis SAP in patients with acute pancreatitis AP. Identifying early biomarkers for SAP can help in risk stratification and guide clinical management. Materials and Methods: This retrospective, single-center observational study included 183 patients diagnosed with AP between January 2022 and January 2023. Patients were classified as SAP or non-SAP based on the 2012 Atlanta Classification. Demographic data, laboratory parameters, and clinical outcomes were analyzed. Lactate clearance was calculated as initial lactate  24-hour lactateinitial lactate  100.. Results: Among 183 patients, 105 57.4 had SAP. SAP patients had significantly longer hospital stays, higher intensive care unit admissions, and increased mortality rates. SAP patients had significantly higher initial and 24-hour lactate levels but lower lactate clearance. Lower lactate clearance was an independent predictor of SAP OR: 3.051, 95 CI: 2.0305.072, p0.001. ROC analysis revealed that lactate clearance had an AUC of 0.835 95 CI: 0.7760.894, with 81.9 sensitivity and 76.9 specificity at a cutoff value of 40.9. Conclusion: Low lactate clearance is strongly associated with SAP development, longer hospitalization, ICU need, and increased mortality. Lactate clearance may serve as a valuable early prognostic marker. Future studies should explore integrating lactate clearance with markers such as SII, SIIalbumin ratio, and RDW to enhance risk stratification and clinical decision-making in AP.

 Amaç: Bu çalışma, akut pankreatit AP hastalarında laktat klirensinin şiddetli akut pankreatit SAP gelişimini öngörmedeki prognostik değerini değerlendirmeyi amaçlamaktadır. SAP için erken dönemde belirteçlerin tanımlanması, risk sınıflandırmasını kolaylaştırarak klinik yönetimi yönlendirebilir. Gereç ve Yöntem: Bu retrospektif, tek merkezli gözlemsel çalışma, Ocak 2022 ile Ocak 2023 tarihleri arasında AP tanısı alan 183 hastayı içermektedir. Hastalar, 2012 Atlanta Klasifikasyonuna göre SAP ve non-SAP gruplarına ayrıldı. Demografik veriler, laboratuvar parametreleri ve klinik sonuçlar analiz edildi. Laktat klirensi ilk laktat  24. saat laktat  ilk laktat  100 formülü ile hesaplandı. Bulgular: Toplam 183 hastanın 105i 57.4 SAP grubundaydı. SAP hastalarında hastane yatış süresi, yoğun bakım gereksinimi ve mortalite oranları anlamlı olarak daha yüksekti. SAP hastalarında başlangıç ve 24. saat laktat seviyeleri daha yüksekti, ancak laktat klirensi anlamlı şekilde daha düşüktü. Laktat klirensi, SAP için bağımsız bir belirleyici olarak bulundu OO  3.051, 95 CI: 2.030-5.072, p0.001. ROC analizi, laktat klirensinin 40,9luk bir kesme değerinde 81,9 duyarlılık ve 76,9 özgüllük ile 0,835lik 95 GA: 0,776-0,894 bir AUC sahip olduğunu ortaya koymuştur. Sonuç: Düşük laktat klirensi SAP gelişimi, daha uzun süre hastanede kalma, YBÜ ihtiyacı ve artmış mortalite ile güçlü bir şekilde ilişkilidir. Laktat klirensi değerli bir erken prognostik belirteç olarak hizmet edebilir. Gelecekteki çalışmalar, APde risk sınıflandırmasını ve klinik karar verme sürecini geliştirmek için laktat klirensini SII, SIIalbümin oranı ve RDW gibi belirteçlerle entegre etmeyi araştırmalıdır.

Makale detayları

Prognostic significance of lactate clearance in severe acute pancreatitis

Yazarlar:

Betül Çiğdem Yortanlı | Korhan Kollu | Burcu Kuş | Ekrem Taha Sert | Mehmet Yortanlı

Yayıncı:

Cukurova University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji | İç Hastalıkları | Yoğun Bakım

Dergi:

Cukurova Medical Journal Vol.50 Issue 2, pp.450-459

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001351461

pISSN:

2602-3032

Acute pancreatitis

Lactate clearance

Prognostic biomarkerAkut pankreatit

Laktat klirensi

Prognostik biyobelirteç

Sayı

Makale detayları

Prognostic significance of lactate clearance in severe acute pancreatitis

Yazarlar: Betül Çiğdem Yortanlı | Korhan Kollu | Burcu Kuş | Ekrem Taha Sert | Mehmet Yortanlı

Yayıncı: Cukurova University

Ana Başlıklar: Gastroenteroloji ve Hepatoloji | İç Hastalıkları | Yoğun Bakım

Dergi: Cukurova Medical Journal Vol.50 Issue 2, pp.450-459

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001351461

pISSN: 2602-3032

Acute pancreatitis

Lactate clearance

Prognostic biomarkerAkut pankreatit

Laktat klirensi

Prognostik biyobelirteç

Sayı

Yazarlar:

Betül Çiğdem Yortanlı | Korhan Kollu | Burcu Kuş | Ekrem Taha Sert | Mehmet Yortanlı

Yayıncı:

Cukurova University

Ana Başlıklar:

Gastroenteroloji ve Hepatoloji | İç Hastalıkları | Yoğun Bakım

Dergi:

Cukurova Medical Journal Vol.50 Issue 2, pp.450-459

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001351461

pISSN:

2602-3032