The association of anemia and high neutrophil-lymphocyte ratio with decreased survival in patients with laryngeal cancer treated with radiotherapy

Ela Delikgöz Soykut; Yasemin Kemal; Serkan Kaplan; Cengiz Karaçin; Eylem Odabaşı; Asude Unal; Zehra Er; Suheyla Aytaç Arslan; Yıldız Guney

Makale detayları

The association of anemia and high neutrophil-lymphocyte ratio with decreased survival in patients with laryngeal cancer treated with radiotherapy

Yazarlar:

Ela Delikgöz Soykut | Yasemin Kemal | Serkan Kaplan | Cengiz Karaçin | Eylem Odabaşı | Asude Unal | Zehra Er | Suheyla Aytaç Arslan | Yıldız Guney

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Klinik Onkoloji | Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 3, pp.227-236

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293475

pISSN:

2718-0115

Anahtar kelimeler:

Özet:

 Aims: We aimed to examine the prognostic value of inflammatory markers such as neutrophiltolymphocyte ratio NLR, platelettolymphocyte ratio PLR, systemic immune-inflammation index SII, and anemia on oncological outcomes in patients with laryngeal squamous cell carcinomas LSCC treated with radiotherapy. Methods: 213 LSCC patients analyzed retrospectively. Inflammatory markers were established by examining blood samples taken within 7 days before treatment. Patients were categorized into two groups: low and high according to NLR, PLR, and SII threshold values. In addition, to evaluate the effect of hemoglobin Hb level, the threshold value of each inflammatory marker and Hb level were combined, and 3 groups were formed 3 groups for NLR, 3 groups for PLR, and 3 groups for SII. The relationship between inflammatory markers and overall survival OS, disease-free survival DFS, and local regional recurrence-free survival LRRFS was investigated. Results: In univariate analysis, high NLR, PLR, SII, and low Hb 13 gdl level were associated with worse survival all p0.022, except for PLR and Hb for LRRFS. OS and DFS were significantly better in patients in each group A with a low inflammatory index and high Hb all p0.013. In the multivariate analysis, high NLR and group CNLR high NLR with low Hb were statistically significant predictors of decreased OS HR 1.85, 95 CI 1.05-3.28, p0.033; HR 2.61, 95 CI 1.14-5.97, p0.022 and DFS HR 1.81, 95 CI 1.11-2.96, p0.017; HR 3.32, 95 CI 1.20-9.16, p0.028. Conclusion: NLR may serve as a potential prognostic biomarker in LSCC, and its predictive ability is further enhanced when NLR is combined with Hb level.

 Aims: We aimed to examine the prognostic value of inflammatory markers such as neutrophiltolymphocyte ratio NLR, platelettolymphocyte ratio PLR, systemic immune-inflammation index SII, and anemia on oncological outcomes in patients with laryngeal squamous cell carcinomas LSCC treated with radiotherapy. Methods: 213 LSCC patients analyzed retrospectively. Inflammatory markers were established by examining blood samples taken within 7 days before treatment. Patients were categorized into two groups: low and high according to NLR, PLR, and SII threshold values. In addition, to evaluate the effect of hemoglobin Hb level, the threshold value of each inflammatory marker and Hb level were combined, and 3 groups were formed 3 groups for NLR, 3 groups for PLR, and 3 groups for SII. The relationship between inflammatory markers and overall survival OS, disease-free survival DFS, and local regional recurrence-free survival LRRFS was investigated. Results: In univariate analysis, high NLR, PLR, SII, and low Hb 13 gdl level were associated with worse survival all p0.022, except for PLR and Hb for LRRFS. OS and DFS were significantly better in patients in each group A with a low inflammatory index and high Hb all p0.013. In the multivariate analysis, high NLR and group CNLR high NLR with low Hb were statistically significant predictors of decreased OS HR 1.85, 95 CI 1.05-3.28, p0.033; HR 2.61, 95 CI 1.14-5.97, p0.022 and DFS HR 1.81, 95 CI 1.11-2.96, p0.017; HR 3.32, 95 CI 1.20-9.16, p0.028. Conclusion: NLR may serve as a potential prognostic biomarker in LSCC, and its predictive ability is further enhanced when NLR is combined with Hb level.

 Aims: We aimed to examine the prognostic value of inflammatory markers such as neutrophiltolymphocyte ratio NLR, platelettolymphocyte ratio PLR, systemic immune-inflammation index SII, and anemia on oncological outcomes in patients with laryngeal squamous cell carcinomas LSCC treated with radiotherapy. Methods: 213 LSCC patients analyzed retrospectively. Inflammatory markers were established by examining blood samples taken within 7 days before treatment. Patients were categorized into two groups: low and high according to NLR, PLR, and SII threshold values. In addition, to evaluate the effect of hemoglobin Hb level, the threshold value of each inflammatory marker and Hb level were combined, and 3 groups were formed 3 groups for NLR, 3 groups for PLR, and 3 groups for SII. The relationship between inflammatory markers and overall survival OS, disease-free survival DFS, and local regional recurrence-free survival LRRFS was investigated. Results: In univariate analysis, high NLR, PLR, SII, and low Hb 13 gdl level were associated with worse survival all p0.022, except for PLR and Hb for LRRFS. OS and DFS were significantly better in patients in each group A with a low inflammatory index and high Hb all p0.013. In the multivariate analysis, high NLR and group CNLR high NLR with low Hb were statistically significant predictors of decreased OS HR 1.85, 95 CI 1.05-3.28, p0.033; HR 2.61, 95 CI 1.14-5.97, p0.022 and DFS HR 1.81, 95 CI 1.11-2.96, p0.017; HR 3.32, 95 CI 1.20-9.16, p0.028. Conclusion: NLR may serve as a potential prognostic biomarker in LSCC, and its predictive ability is further enhanced when NLR is combined with Hb level.

 Aims: We aimed to examine the prognostic value of inflammatory markers such as neutrophiltolymphocyte ratio NLR, platelettolymphocyte ratio PLR, systemic immune-inflammation index SII, and anemia on oncological outcomes in patients with laryngeal squamous cell carcinomas LSCC treated with radiotherapy. Methods: 213 LSCC patients analyzed retrospectively. Inflammatory markers were established by examining blood samples taken within 7 days before treatment. Patients were categorized into two groups: low and high according to NLR, PLR, and SII threshold values. In addition, to evaluate the effect of hemoglobin Hb level, the threshold value of each inflammatory marker and Hb level were combined, and 3 groups were formed 3 groups for NLR, 3 groups for PLR, and 3 groups for SII. The relationship between inflammatory markers and overall survival OS, disease-free survival DFS, and local regional recurrence-free survival LRRFS was investigated. Results: In univariate analysis, high NLR, PLR, SII, and low Hb 13 gdl level were associated with worse survival all p0.022, except for PLR and Hb for LRRFS. OS and DFS were significantly better in patients in each group A with a low inflammatory index and high Hb all p0.013. In the multivariate analysis, high NLR and group CNLR high NLR with low Hb were statistically significant predictors of decreased OS HR 1.85, 95 CI 1.05-3.28, p0.033; HR 2.61, 95 CI 1.14-5.97, p0.022 and DFS HR 1.81, 95 CI 1.11-2.96, p0.017; HR 3.32, 95 CI 1.20-9.16, p0.028. Conclusion: NLR may serve as a potential prognostic biomarker in LSCC, and its predictive ability is further enhanced when NLR is combined with Hb level.

Makale detayları

The association of anemia and high neutrophil-lymphocyte ratio with decreased survival in patients with laryngeal cancer treated with radiotherapy

Yazarlar:

Ela Delikgöz Soykut | Yasemin Kemal | Serkan Kaplan | Cengiz Karaçin | Eylem Odabaşı | Asude Unal | Zehra Er | Suheyla Aytaç Arslan | Yıldız Guney

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Klinik Onkoloji | Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 3, pp.227-236

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293475

pISSN:

2718-0115

Anemia

laryngeal squamous cell carcinoma

neutrophil-to-lymphocyte ratio

platelet‐to‐lymphocyte ratio

radiotherapy

systemic immune-inflammation index

Sayı

Makale detayları

The association of anemia and high neutrophil-lymphocyte ratio with decreased survival in patients with laryngeal cancer treated with radiotherapy

Yazarlar: Ela Delikgöz Soykut | Yasemin Kemal | Serkan Kaplan | Cengiz Karaçin | Eylem Odabaşı | Asude Unal | Zehra Er | Suheyla Aytaç Arslan | Yıldız Guney

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Klinik Onkoloji | Sağlık Kurumları Yönetimi

Dergi: Anatolian Current Medical Journal Vol.5 Issue 3, pp.227-236

Belge Tipi: Makale

Yayın Tarihi: 7/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001293475

pISSN: 2718-0115

Anemia

laryngeal squamous cell carcinoma

neutrophil-to-lymphocyte ratio

platelet‐to‐lymphocyte ratio

radiotherapy

systemic immune-inflammation index

Sayı

Yazarlar:

Ela Delikgöz Soykut | Yasemin Kemal | Serkan Kaplan | Cengiz Karaçin | Eylem Odabaşı | Asude Unal | Zehra Er | Suheyla Aytaç Arslan | Yıldız Guney

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Klinik Onkoloji | Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 3, pp.227-236

Belge Tipi:

Makale

Yayın Tarihi:

7/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001293475

pISSN:

2718-0115