FFT-Adsorptive Voltammetric Technique for Pico-Level Determination of Tetracycline in Capsules at an Au Microelectrode in Flowing Solutions

Parviz NOROUZI; Mohammad Reza GANJALI; Parandis DANESHGAR

Makale detayları

FFT-Adsorptive Voltammetric Technique for Pico-Level Determination of Tetracycline in Capsules at an Au Microelectrode in Flowing Solutions

Yazarlar:

Parviz NOROUZI | Mohammad Reza GANJALI | Parandis DANESHGAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.279-291

Belge Tipi:

Makale

Yayın Tarihi:

2/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000728707

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527

Özet:

 

This study illustrates a novel method for fast monitoring of  tetracycline in flow-injection systems.  The fast Fourier  transformation, along with continuous cyclic voltammetry (FFTCV) at a  gold microelectrode in a flowing solution system, was used for the  determination of tetracycline in its pharmaceutical formulation.  The  benefit of the developed technique is that it is simple, precise,  accurate, time-saving, and economical compared to all of the  previously reported methods.  The effects of various parameters on the  sensitivity of the method were investigated.    Three considerable advantages are demonstrated by this method, which  other methods do not possess.  Firstly, there is no requirement for  oxygen removal from the test solution; secondly, a picomolar detection  limit is gained; and, finally, rapid determination of any such  compound in a broad range of chromatographic methods.    As a result, the method was found to be linear over the concentration  range of    16-440 pg/mL (r = 0.9962), with a limit of detection and quantitation  of 4.5 and 16 pg/mL, respectively.  Furthermore, the technique shows  the requisite accuracy, sensitivity, precision, and selectivity to  assay tetracycline in capsules.

 

This study illustrates a novel method for fast monitoring of  tetracycline in flow-injection systems.  The fast Fourier  transformation, along with continuous cyclic voltammetry (FFTCV) at a  gold microelectrode in a flowing solution system, was used for the  determination of tetracycline in its pharmaceutical formulation.  The  benefit of the developed technique is that it is simple, precise,  accurate, time-saving, and economical compared to all of the  previously reported methods.  The effects of various parameters on the  sensitivity of the method were investigated.    Three considerable advantages are demonstrated by this method, which  other methods do not possess.  Firstly, there is no requirement for  oxygen removal from the test solution; secondly, a picomolar detection  limit is gained; and, finally, rapid determination of any such  compound in a broad range of chromatographic methods.    As a result, the method was found to be linear over the concentration  range of    16-440 pg/mL (r = 0.9962), with a limit of detection and quantitation  of 4.5 and 16 pg/mL, respectively.  Furthermore, the technique shows  the requisite accuracy, sensitivity, precision, and selectivity to  assay tetracycline in capsules.

Makale detayları

FFT-Adsorptive Voltammetric Technique for Pico-Level Determination of Tetracycline in Capsules at an Au Microelectrode in Flowing Solutions

Yazarlar: Parviz NOROUZI | Mohammad Reza GANJALI | Parandis DANESHGAR

Yayıncı: TUBITAK

Dergi: Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.279-291

Belge Tipi: Makale

Yayın Tarihi: 2/2007

Belge Dili: Türkçe

Document ID (Org No.): 2000728707

Sıklık: İki Aylık

eISSN: 1303-6130

pISSN: 1300-0527

Sayı

Yazarlar:

Parviz NOROUZI | Mohammad Reza GANJALI | Parandis DANESHGAR

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Chemistry 2007 Vol.31 Issue 3, pp.279-291

Belge Tipi:

Makale

Yayın Tarihi:

2/2007

Belge Dili:

Türkçe

Document ID (Org No.):

2000728707

Sıklık:

İki Aylık

eISSN:

1303-6130

pISSN:

1300-0527