Antibacterial and Antioxidant Activity Evaluation of Bis-Substituted İsovanillin Derivatives

Zehra Tekin; Yener Tekeli; Zehra Küçükbay; Nebih Lolak; Gönül Yapar; Süleyman Akocak

Makale detayları

Antibacterial and Antioxidant Activity Evaluation of Bis-Substituted İsovanillin Derivatives

Yazarlar:

Zehra Tekin | Yener Tekeli | Zehra Küçükbay | Nebih Lolak | Gönül Yapar | Süleyman Akocak

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.10 Issue 2, pp.435-442

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284132

pISSN:

2149-0120

Anahtar kelimeler:

Özet:

 Herein, a series of twelve bis-hydrazone substituted isovanilline derivatives 3a-l, were freshly re-synthesized by the reaction of bis-aldehydes with substituted hydrazide derivatives since these compounds previously showed potent aldose reductase inhibition properties. The obtained compounds were tested for their potential antibacterial and antioxidant activities. In the present study, four different bacterial strains were used, including Gram-positive Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and Gram-negative Pseudomonas aeruginosa ATCC 10231, Escherichia coli ATCC 25912. On the other hand, the antioxidant capacities of freshly re-synthesized bis-hydrazone substituted isovanilline derivatives were determined by using several antioxidant methods, including DPPH free radical scanvenging, TEAC cupric reducing CUPRAC and metal chelating activity methods. Several lead molecules were discovered as a potential bacterial inhibitors against S. aureus and E. coli bacterial strains. More specifically, compounds 3g R-H and 3j R -4Cl showed great inhibition properties against E. coli bacterial strains by having MIC values of 1.56 and 6.25 µgmL, respectively. Moreover, none of the compounds showed potent antioxidant activity against tested methods with respect to compared standards.

 Herein, a series of twelve bis-hydrazone substituted isovanilline derivatives 3a-l, were freshly re-synthesized by the reaction of bis-aldehydes with substituted hydrazide derivatives since these compounds previously showed potent aldose reductase inhibition properties. The obtained compounds were tested for their potential antibacterial and antioxidant activities. In the present study, four different bacterial strains were used, including Gram-positive Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and Gram-negative Pseudomonas aeruginosa ATCC 10231, Escherichia coli ATCC 25912. On the other hand, the antioxidant capacities of freshly re-synthesized bis-hydrazone substituted isovanilline derivatives were determined by using several antioxidant methods, including DPPH free radical scanvenging, TEAC cupric reducing CUPRAC and metal chelating activity methods. Several lead molecules were discovered as a potential bacterial inhibitors against S. aureus and E. coli bacterial strains. More specifically, compounds 3g R-H and 3j R -4Cl showed great inhibition properties against E. coli bacterial strains by having MIC values of 1.56 and 6.25 µgmL, respectively. Moreover, none of the compounds showed potent antioxidant activity against tested methods with respect to compared standards.

 Herein, a series of twelve bis-hydrazone substituted isovanilline derivatives 3a-l, were freshly re-synthesized by the reaction of bis-aldehydes with substituted hydrazide derivatives since these compounds previously showed potent aldose reductase inhibition properties. The obtained compounds were tested for their potential antibacterial and antioxidant activities. In the present study, four different bacterial strains were used, including Gram-positive Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and Gram-negative Pseudomonas aeruginosa ATCC 10231, Escherichia coli ATCC 25912. On the other hand, the antioxidant capacities of freshly re-synthesized bis-hydrazone substituted isovanilline derivatives were determined by using several antioxidant methods, including DPPH free radical scanvenging, TEAC cupric reducing CUPRAC and metal chelating activity methods. Several lead molecules were discovered as a potential bacterial inhibitors against S. aureus and E. coli bacterial strains. More specifically, compounds 3g R-H and 3j R -4Cl showed great inhibition properties against E. coli bacterial strains by having MIC values of 1.56 and 6.25 µgmL, respectively. Moreover, none of the compounds showed potent antioxidant activity against tested methods with respect to compared standards.

 Herein, a series of twelve bis-hydrazone substituted isovanilline derivatives 3a-l, were freshly re-synthesized by the reaction of bis-aldehydes with substituted hydrazide derivatives since these compounds previously showed potent aldose reductase inhibition properties. The obtained compounds were tested for their potential antibacterial and antioxidant activities. In the present study, four different bacterial strains were used, including Gram-positive Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and Gram-negative Pseudomonas aeruginosa ATCC 10231, Escherichia coli ATCC 25912. On the other hand, the antioxidant capacities of freshly re-synthesized bis-hydrazone substituted isovanilline derivatives were determined by using several antioxidant methods, including DPPH free radical scanvenging, TEAC cupric reducing CUPRAC and metal chelating activity methods. Several lead molecules were discovered as a potential bacterial inhibitors against S. aureus and E. coli bacterial strains. More specifically, compounds 3g R-H and 3j R -4Cl showed great inhibition properties against E. coli bacterial strains by having MIC values of 1.56 and 6.25 µgmL, respectively. Moreover, none of the compounds showed potent antioxidant activity against tested methods with respect to compared standards.

Makale detayları

Antibacterial and Antioxidant Activity Evaluation of Bis-Substituted İsovanillin Derivatives

Yazarlar:

Zehra Tekin | Yener Tekeli | Zehra Küçükbay | Nebih Lolak | Gönül Yapar | Süleyman Akocak

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.10 Issue 2, pp.435-442

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284132

pISSN:

2149-0120

Hydrazone

isovanillin

antioxidant

antibacterial.

Sayı

Makale detayları

Antibacterial and Antioxidant Activity Evaluation of Bis-Substituted İsovanillin Derivatives

Yazarlar: Zehra Tekin | Yener Tekeli | Zehra Küçükbay | Nebih Lolak | Gönül Yapar | Süleyman Akocak

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Biochemistry and Cell Biology (Other)

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry Vol.10 Issue 2, pp.435-442

Belge Tipi: Makale

Yayın Tarihi: 5/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001284132

pISSN: 2149-0120

Hydrazone

isovanillin

antioxidant

antibacterial.

Sayı

Yazarlar:

Zehra Tekin | Yener Tekeli | Zehra Küçükbay | Nebih Lolak | Gönül Yapar | Süleyman Akocak

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.10 Issue 2, pp.435-442

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284132

pISSN:

2149-0120