In Vitro Inhibitory Effects of Some Antiviral, Antidiabetic, and Non-Steroidal Anti-Inflammatory Drug Active Compounds on α-Glucosidase and Myeloperoxidase Activities

Fatma Yaşar Boztaş; Sevim Tunalı

Makale detayları

In Vitro Inhibitory Effects of Some Antiviral, Antidiabetic, and Non-Steroidal Anti-Inflammatory Drug Active Compounds on α-Glucosidase and Myeloperoxidase Activities

Yazarlar:

Fatma Yaşar Boztaş | Sevim Tunalı

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 2, pp.691-698

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001309587

pISSN:

2149-0120

Anahtar kelimeler:

Özet:

 In recent decades, interest in enzyme inhibition, such as myeloperoxidase MPO and glycosidases, has dramatically increased, mainly because these enzymes play a vital role in many biological processes. Based on the biological potential associated with these enzymes, instead of several glycosidase and myeloperoxidase MPO inhibitors that have been developed, there are not enough studies on the inhibition effects of widely used types of antivirals aciclovir, tenofovir, oral antidiabetics glibenclamide, glibornuride, glurenorm, met-formin, and non-steroidal anti-inflammatory drugs NSAIDs active substances benzydamine HCl, diclofenac, indomethacin, ketorolac tromethamine, paracetamol, salicylic acid today. For that reason, the aim of our study is to investigate the inhibition effects of these 12 different drug active substances on α-glucosidase and MPO activities. According to the obtained results, the screened drug active substances acyclovir, glibornuride, and paracetamol inhibited α-glucosidase with the lowest IC50 value, while similarly low values for MPO were found by tenofavir, glurenorm, and indomethacin. In our study, we can suggest that these active pharmaceu-tical ingredients may contribute to the pharmaceutical industry due to their inhibitory effects on α-glucosidase and MPO in vitro.

 In recent decades, interest in enzyme inhibition, such as myeloperoxidase MPO and glycosidases, has dramatically increased, mainly because these enzymes play a vital role in many biological processes. Based on the biological potential associated with these enzymes, instead of several glycosidase and myeloperoxidase MPO inhibitors that have been developed, there are not enough studies on the inhibition effects of widely used types of antivirals aciclovir, tenofovir, oral antidiabetics glibenclamide, glibornuride, glurenorm, met-formin, and non-steroidal anti-inflammatory drugs NSAIDs active substances benzydamine HCl, diclofenac, indomethacin, ketorolac tromethamine, paracetamol, salicylic acid today. For that reason, the aim of our study is to investigate the inhibition effects of these 12 different drug active substances on α-glucosidase and MPO activities. According to the obtained results, the screened drug active substances acyclovir, glibornuride, and paracetamol inhibited α-glucosidase with the lowest IC50 value, while similarly low values for MPO were found by tenofavir, glurenorm, and indomethacin. In our study, we can suggest that these active pharmaceu-tical ingredients may contribute to the pharmaceutical industry due to their inhibitory effects on α-glucosidase and MPO in vitro.

 In recent decades, interest in enzyme inhibition, such as myeloperoxidase MPO and glycosidases, has dramatically increased, mainly because these enzymes play a vital role in many biological processes. Based on the biological potential associated with these enzymes, instead of several glycosidase and myeloperoxidase MPO inhibitors that have been developed, there are not enough studies on the inhibition effects of widely used types of antivirals aciclovir, tenofovir, oral antidiabetics glibenclamide, glibornuride, glurenorm, met-formin, and non-steroidal anti-inflammatory drugs NSAIDs active substances benzydamine HCl, diclofenac, indomethacin, ketorolac tromethamine, paracetamol, salicylic acid today. For that reason, the aim of our study is to investigate the inhibition effects of these 12 different drug active substances on α-glucosidase and MPO activities. According to the obtained results, the screened drug active substances acyclovir, glibornuride, and paracetamol inhibited α-glucosidase with the lowest IC50 value, while similarly low values for MPO were found by tenofavir, glurenorm, and indomethacin. In our study, we can suggest that these active pharmaceu-tical ingredients may contribute to the pharmaceutical industry due to their inhibitory effects on α-glucosidase and MPO in vitro.

 In recent decades, interest in enzyme inhibition, such as myeloperoxidase MPO and glycosidases, has dramatically increased, mainly because these enzymes play a vital role in many biological processes. Based on the biological potential associated with these enzymes, instead of several glycosidase and myeloperoxidase MPO inhibitors that have been developed, there are not enough studies on the inhibition effects of widely used types of antivirals aciclovir, tenofovir, oral antidiabetics glibenclamide, glibornuride, glurenorm, met-formin, and non-steroidal anti-inflammatory drugs NSAIDs active substances benzydamine HCl, diclofenac, indomethacin, ketorolac tromethamine, paracetamol, salicylic acid today. For that reason, the aim of our study is to investigate the inhibition effects of these 12 different drug active substances on α-glucosidase and MPO activities. According to the obtained results, the screened drug active substances acyclovir, glibornuride, and paracetamol inhibited α-glucosidase with the lowest IC50 value, while similarly low values for MPO were found by tenofavir, glurenorm, and indomethacin. In our study, we can suggest that these active pharmaceu-tical ingredients may contribute to the pharmaceutical industry due to their inhibitory effects on α-glucosidase and MPO in vitro.

Makale detayları

In Vitro Inhibitory Effects of Some Antiviral, Antidiabetic, and Non-Steroidal Anti-Inflammatory Drug Active Compounds on α-Glucosidase and Myeloperoxidase Activities

Yazarlar:

Fatma Yaşar Boztaş | Sevim Tunalı

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 2, pp.691-698

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001309587

pISSN:

2149-0120

α-Glucosidase

myeloperoxidase

enzyme inhibition

drug active compounds.

Sayı

Makale detayları

In Vitro Inhibitory Effects of Some Antiviral, Antidiabetic, and Non-Steroidal Anti-Inflammatory Drug Active Compounds on α-Glucosidase and Myeloperoxidase Activities

Yazarlar: Fatma Yaşar Boztaş | Sevim Tunalı

Yayıncı: Turkish Chemical Society

Ana Başlıklar: Biochemistry and Cell Biology (Other)

Dergi: Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 2, pp.691-698

Belge Tipi: Makale

Yayın Tarihi: 5/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001309587

pISSN: 2149-0120

α-Glucosidase

myeloperoxidase

enzyme inhibition

drug active compounds.

Sayı

Yazarlar:

Fatma Yaşar Boztaş | Sevim Tunalı

Yayıncı:

Turkish Chemical Society

Ana Başlıklar:

Biochemistry and Cell Biology (Other)

Dergi:

Journal of the Turkish Chemical Society Section A: Chemistry Vol.11 Issue 2, pp.691-698

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001309587

pISSN:

2149-0120