Effects of Gingko Glycosid (EGb 761) on Some  Vascular Endothelial Functions and Renal  Histology in Rabbits With Acute Cyclosporine  Nephrotoxicity

N. Yılmaz SELÇUK

Makale detayları

Effects of Gingko Glycosid (EGb 761) on Some Vascular Endothelial Functions and Renal Histology in Rabbits With Acute Cyclosporine Nephrotoxicity

Yazarlar:

N. Yılmaz SELÇUK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 2, pp.109-114

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757662

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

In recent years, Endothelin-1 (ET-1),  Platelet Activating Factor (PAF) and  thromboxane have been considered  responsible for the pathogenesis of acute  cyclosporine nephrotoxicity (ACN). The aim of  this study was to investigate the effects of the  PAF antagonist gingko glycosid (EGb 761) on  both renal histology and ET-1 and Nitric Oxide  (NO) levels in experimental ACN.  This study was carried out on 30 albino  rabbits, divided into three groups. They were:  group A (n=10) the control, group B (n=10),  which was given intravenous cyclosporine  (15mg/kg/day) and group C (n=10), which  was given oral gingko glycosid  (2.5mg/kg/day) in addition to cyclosporine.  Plasma ET-1 and NO levels and renal histology  were investigated in all of the groups. Data  analysis was performed by Kruskall-Wallis  one-way Anova and Mann Whitney-U tests.  Plasma ET-1 levels in groups B and C were  higher than in the controls (p.

 

In recent years, Endothelin-1 (ET-1),  Platelet Activating Factor (PAF) and  thromboxane have been considered  responsible for the pathogenesis of acute  cyclosporine nephrotoxicity (ACN). The aim of  this study was to investigate the effects of the  PAF antagonist gingko glycosid (EGb 761) on  both renal histology and ET-1 and Nitric Oxide  (NO) levels in experimental ACN.  This study was carried out on 30 albino  rabbits, divided into three groups. They were:  group A (n=10) the control, group B (n=10),  which was given intravenous cyclosporine  (15mg/kg/day) and group C (n=10), which  was given oral gingko glycosid  (2.5mg/kg/day) in addition to cyclosporine.  Plasma ET-1 and NO levels and renal histology  were investigated in all of the groups. Data  analysis was performed by Kruskall-Wallis  one-way Anova and Mann Whitney-U tests.  Plasma ET-1 levels in groups B and C were  higher than in the controls (p.

Makale detayları

Effects of Gingko Glycosid (EGb 761) on Some Vascular Endothelial Functions and Renal Histology in Rabbits With Acute Cyclosporine Nephrotoxicity

Yazarlar:

N. Yılmaz SELÇUK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 2, pp.109-114

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757662

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Acute nephrotoxicity

Cyclosporine

Gingko glycosid.

Sayı

Makale detayları

Effects of Gingko Glycosid (EGb 761) on Some Vascular Endothelial Functions and Renal Histology in Rabbits With Acute Cyclosporine Nephrotoxicity

Yazarlar: N. Yılmaz SELÇUK

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2000 Vol.30 Issue 2, pp.109-114

Belge Tipi: Makale

Yayın Tarihi: 1/2000

Belge Dili: Türkçe

Document ID (Org No.): 2000757662

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Acute nephrotoxicity

Cyclosporine

Gingko glycosid.

Sayı

Yazarlar:

N. Yılmaz SELÇUK

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2000 Vol.30 Issue 2, pp.109-114

Belge Tipi:

Makale

Yayın Tarihi:

1/2000

Belge Dili:

Türkçe

Document ID (Org No.):

2000757662

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144