Evaluation of the relationship between insulin resistance and different phenotypes of polycystic ovary syndrome

Mehmet Ağar; Murat Önal; Halime Çalı Öztürk

Makale detayları

Evaluation of the relationship between insulin resistance and different phenotypes of polycystic ovary syndrome

Yazarlar:

Mehmet Ağar | Murat Önal | Halime Çalı Öztürk

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum | Sağlık Kurumları Yönetimi

Dergi:

Journal of Medicine and Palliative Care Vol.4 Issue 3, pp.183-188

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292896

pISSN:

2717-7505

Anahtar kelimeler:

Özet:

 Aims: Polycystic ovary syndrome PCOS is a common endocrine disorder in women. Hyperinsulinemia and insulin resistance IR are the most important metabolic abnormalities that affect these patients. This study aimed to investigate the variables related to IR in patients with different PCOS phenotypes. Methods: This retrospective study included 389 women diagnosed with PCOS in Bezmialem Hospital between november 2020 and september 2022. Information about patients was collected through their electronic records. PCOS was diagnosed based on the Rotterdam criteria, and four phenotypes of A oligoovulation hyperandrogenismPCO, B oligoovulationhyperandrogenism, C hyperandrogenism PCO, and D oligoovulationabsent PCO were considered for PCOS. The homeostatic model assessment for ınsulin resistance HOMA-IR was used to evaluate IR. The Mann-Whitney U test was performed to study the difference between the groups. Results: The highest value of HOMA-IR was for the phenotype B group, and the lowest value was for the phenotype C group. However, the difference between the groups was not significant p0.221. Estradiol and free T4 were significantly higher in the phenotype A group p0.001. Thyroid-stimulating hormone TSH, prolactin, anti-mullerian hormone AMH, fasting insulin, total testosterone, and red blood cell distribution width RDW were significantly higher in the phenotype B group p0.001. Total cholesterol, high density lipoprotein HDL, leukocyte, basophil, and monocyte were significantly higher in the phenotype C group p0.001. Also, MPV values were significantly higher in the phenotype D group p0.001. Conclusion: The results showed that the variables related to IR in phenotypes A and B of PCOS are higher than in other phenotypes.

 Aims: Polycystic ovary syndrome PCOS is a common endocrine disorder in women. Hyperinsulinemia and insulin resistance IR are the most important metabolic abnormalities that affect these patients. This study aimed to investigate the variables related to IR in patients with different PCOS phenotypes. Methods: This retrospective study included 389 women diagnosed with PCOS in Bezmialem Hospital between november 2020 and september 2022. Information about patients was collected through their electronic records. PCOS was diagnosed based on the Rotterdam criteria, and four phenotypes of A oligoovulation hyperandrogenismPCO, B oligoovulationhyperandrogenism, C hyperandrogenism PCO, and D oligoovulationabsent PCO were considered for PCOS. The homeostatic model assessment for ınsulin resistance HOMA-IR was used to evaluate IR. The Mann-Whitney U test was performed to study the difference between the groups. Results: The highest value of HOMA-IR was for the phenotype B group, and the lowest value was for the phenotype C group. However, the difference between the groups was not significant p0.221. Estradiol and free T4 were significantly higher in the phenotype A group p0.001. Thyroid-stimulating hormone TSH, prolactin, anti-mullerian hormone AMH, fasting insulin, total testosterone, and red blood cell distribution width RDW were significantly higher in the phenotype B group p0.001. Total cholesterol, high density lipoprotein HDL, leukocyte, basophil, and monocyte were significantly higher in the phenotype C group p0.001. Also, MPV values were significantly higher in the phenotype D group p0.001. Conclusion: The results showed that the variables related to IR in phenotypes A and B of PCOS are higher than in other phenotypes.

 Aims: Polycystic ovary syndrome PCOS is a common endocrine disorder in women. Hyperinsulinemia and insulin resistance IR are the most important metabolic abnormalities that affect these patients. This study aimed to investigate the variables related to IR in patients with different PCOS phenotypes. Methods: This retrospective study included 389 women diagnosed with PCOS in Bezmialem Hospital between november 2020 and september 2022. Information about patients was collected through their electronic records. PCOS was diagnosed based on the Rotterdam criteria, and four phenotypes of A oligoovulation hyperandrogenismPCO, B oligoovulationhyperandrogenism, C hyperandrogenism PCO, and D oligoovulationabsent PCO were considered for PCOS. The homeostatic model assessment for ınsulin resistance HOMA-IR was used to evaluate IR. The Mann-Whitney U test was performed to study the difference between the groups. Results: The highest value of HOMA-IR was for the phenotype B group, and the lowest value was for the phenotype C group. However, the difference between the groups was not significant p0.221. Estradiol and free T4 were significantly higher in the phenotype A group p0.001. Thyroid-stimulating hormone TSH, prolactin, anti-mullerian hormone AMH, fasting insulin, total testosterone, and red blood cell distribution width RDW were significantly higher in the phenotype B group p0.001. Total cholesterol, high density lipoprotein HDL, leukocyte, basophil, and monocyte were significantly higher in the phenotype C group p0.001. Also, MPV values were significantly higher in the phenotype D group p0.001. Conclusion: The results showed that the variables related to IR in phenotypes A and B of PCOS are higher than in other phenotypes.

 Amaç: Polikistik over sendromu PKOS kadınlarda sık görülen bir endokrin bozukluktur. Hiperinsülinemi ve insülin direnci IR, bu hastaları etkileyen en önemli metabolik anormalliklerdir. Bu çalışma, farklı PKOS fenotiplerine sahip hastalarda IR ile ilişkili değişkenleri araştırmayı amaçladı. Yöntemler: Bu retrospektif çalışmaya, Kasım 2020-Eylül 2022 tarihleri arasında XXXXXXXXXXXX hastanesinde PKOS tanısı alan 389 kadın dahil edildi. Hastalara ait bilgiler elektronik kayıtlarından toplandı. PKOS, Rotterdam kriterlerine göre teşhis edildi ve PKOS için dört fenotip dikkate alındı. İnsülin direnci için homeostatik model değerlendirmesi HOMA-IR, IRyi değerlendirmek için kullanıldı. Gruplar arasındaki farkı incelemek için Mann-Whitney U testi yapıldı. Bulgular: HOMA-IRnin en yüksek değeri fenotip B grubu için, en düşük değeri fenotip C grubu içindi. Ancak gruplar arasındaki fark anlamlı değildi p0,221. Estradiol ve serbest T4 fenotip A grubunda anlamlı olarak yüksekti p0.001. Tiroid uyarıcı hormon TSH, prolaktin, anti-müllerian hormon AMH, açlık insülini, total testosteron ve alyuvar dağılım genişliği RDW fenotip B grubunda anlamlı olarak yüksekti p 0.001. Toplam kolesterol, yüksek yoğunluklu lipoprotein HDL, lökosit, bazofil ve monosit fenotip C grubunda anlamlı olarak yüksekti p 0.001. Ayrıca fenotip D grubunda MPV değerleri anlamlı olarak yüksekti p 0,001. Sonuç: Sonuçlar PKOS fenotip A ve Bde IR ile ilişkili değişkenlerin diğer fenotiplere göre daha yüksek olduğunu göstermiştir. Anahtar Kelimeler: Polikistik Over Sendromu, insülin direnci, HOMA-IR, RDW.

Makale detayları

Evaluation of the relationship between insulin resistance and different phenotypes of polycystic ovary syndrome

Yazarlar:

Mehmet Ağar | Murat Önal | Halime Çalı Öztürk

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum | Sağlık Kurumları Yönetimi

Dergi:

Journal of Medicine and Palliative Care Vol.4 Issue 3, pp.183-188

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292896

pISSN:

2717-7505

Polycystic ovary syndrome

insulin resistance

HOMA-IR

RDWPolycystic Ovary Syndrome

insulin resistance

HOMA-IR

RDW

Sayı

Makale detayları

Yazarlar: Mehmet Ağar | Murat Önal | Halime Çalı Öztürk

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Kadın Hastalıkları ve Doğum | Sağlık Kurumları Yönetimi

Dergi: Journal of Medicine and Palliative Care Vol.4 Issue 3, pp.183-188

Belge Tipi: Makale

Yayın Tarihi: 6/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001292896

pISSN: 2717-7505

Sayı

Yazarlar:

Mehmet Ağar | Murat Önal | Halime Çalı Öztürk

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Kadın Hastalıkları ve Doğum | Sağlık Kurumları Yönetimi

Dergi:

Journal of Medicine and Palliative Care Vol.4 Issue 3, pp.183-188

Belge Tipi:

Makale

Yayın Tarihi:

6/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001292896

pISSN:

2717-7505