Invertebrates living in polluted environments are potential  source of novel anticancer agents

N.A.

Makale detayları

Invertebrates living in polluted environments are potential source of novel anticancer agents

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 6, pp.1079-1089

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347956

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 One of the leading causes of mortality and morbidity worldwide, cancer is a major medical concern with 14.1 and 8.2 million cases of new cancer cases and death cases recorded in 2012 alone. The number of deaths related to cancer are still on the rise despite various treatment options. Hence, there is a need for the identification of anticancer agents for treatment. This study focused on identifying anticancer agents from invertebrates thriving in polluted environments; Acheta domesticus cricket, Anadara granosa blood clam, Blaptica dubia cockroach, Penaeus monodon tiger prawn and Scolpendra subspinipes centipede respectively. We hypothesized that gut microbes of animalspests living in polluted environments such as cockroaches are a potential source of novel anticancer agents. To evaluate this hypothesis, invertebrates were dissected and their gut bacteria were identified and conditioned media were prepared. The conditioned media were used to conduct cytotoxicity assays, cell survival assays and cell growth assays, against two cancer cell lines cervical and prostate cancer cells as well as normal cells HaCaT, aneuploid immortal keratinocyte. The results revealed that conditioned media from tiger prawn Pseudomonas oryzihabitans and centipede Kocuria varians exhibited significant cytotoxic and growth inhibitory effect against the cell lines tested. However, further studies need to be conducted to identify and characterize the active molecules.

 One of the leading causes of mortality and morbidity worldwide, cancer is a major medical concern with 14.1 and 8.2 million cases of new cancer cases and death cases recorded in 2012 alone. The number of deaths related to cancer are still on the rise despite various treatment options. Hence, there is a need for the identification of anticancer agents for treatment. This study focused on identifying anticancer agents from invertebrates thriving in polluted environments; Acheta domesticus cricket, Anadara granosa blood clam, Blaptica dubia cockroach, Penaeus monodon tiger prawn and Scolpendra subspinipes centipede respectively. We hypothesized that gut microbes of animalspests living in polluted environments such as cockroaches are a potential source of novel anticancer agents. To evaluate this hypothesis, invertebrates were dissected and their gut bacteria were identified and conditioned media were prepared. The conditioned media were used to conduct cytotoxicity assays, cell survival assays and cell growth assays, against two cancer cell lines cervical and prostate cancer cells as well as normal cells HaCaT, aneuploid immortal keratinocyte. The results revealed that conditioned media from tiger prawn Pseudomonas oryzihabitans and centipede Kocuria varians exhibited significant cytotoxic and growth inhibitory effect against the cell lines tested. However, further studies need to be conducted to identify and characterize the active molecules.

 One of the leading causes of mortality and morbidity worldwide, cancer is a major medical concern with 14.1 and 8.2 million cases of new cancer cases and death cases recorded in 2012 alone. The number of deaths related to cancer are still on the rise despite various treatment options. Hence, there is a need for the identification of anticancer agents for treatment. This study focused on identifying anticancer agents from invertebrates thriving in polluted environments; Acheta domesticus cricket, Anadara granosa blood clam, Blaptica dubia cockroach, Penaeus monodon tiger prawn and Scolpendra subspinipes centipede respectively. We hypothesized that gut microbes of animalspests living in polluted environments such as cockroaches are a potential source of novel anticancer agents. To evaluate this hypothesis, invertebrates were dissected and their gut bacteria were identified and conditioned media were prepared. The conditioned media were used to conduct cytotoxicity assays, cell survival assays and cell growth assays, against two cancer cell lines cervical and prostate cancer cells as well as normal cells HaCaT, aneuploid immortal keratinocyte. The results revealed that conditioned media from tiger prawn Pseudomonas oryzihabitans and centipede Kocuria varians exhibited significant cytotoxic and growth inhibitory effect against the cell lines tested. However, further studies need to be conducted to identify and characterize the active molecules.

 One of the leading causes of mortality and morbidity worldwide, cancer is a major medical concern with 14.1 and 8.2 million cases of new cancer cases and death cases recorded in 2012 alone. The number of deaths related to cancer are still on the rise despite various treatment options. Hence, there is a need for the identification of anticancer agents for treatment. This study focused on identifying anticancer agents from invertebrates thriving in polluted environments; Acheta domesticus cricket, Anadara granosa blood clam, Blaptica dubia cockroach, Penaeus monodon tiger prawn and Scolpendra subspinipes centipede respectively. We hypothesized that gut microbes of animalspests living in polluted environments such as cockroaches are a potential source of novel anticancer agents. To evaluate this hypothesis, invertebrates were dissected and their gut bacteria were identified and conditioned media were prepared. The conditioned media were used to conduct cytotoxicity assays, cell survival assays and cell growth assays, against two cancer cell lines cervical and prostate cancer cells as well as normal cells HaCaT, aneuploid immortal keratinocyte. The results revealed that conditioned media from tiger prawn Pseudomonas oryzihabitans and centipede Kocuria varians exhibited significant cytotoxic and growth inhibitory effect against the cell lines tested. However, further studies need to be conducted to identify and characterize the active molecules.

Makale detayları

Invertebrates living in polluted environments are potential source of novel anticancer agents

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 6, pp.1079-1089

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347956

pISSN:

2630-6344

Insects

pests

cancer

treatment

cytotoxicity

growth inhibition

Sayı

Makale detayları

Invertebrates living in polluted environments are potential source of novel anticancer agents

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Biochemistry

Dergi: Journal of Research in Pharmacy Vol.23 Issue 6, pp.1079-1089

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347956

pISSN: 2630-6344

Insects

pests

cancer

treatment

cytotoxicity

growth inhibition

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Biochemistry

Dergi:

Journal of Research in Pharmacy Vol.23 Issue 6, pp.1079-1089

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347956

pISSN:

2630-6344