The Effect of Metabolic PET Parameters on Survival Outcome in Malignant Pleural Mesothelioma

Nadiye AKDENİZ; Mehmet KÜÇÜKÖNER; Muhammet Ali KAPLAN; Zuhat URAKÇI; Oğur KARHAN; Halis YERLİKAYA; Şahin LAÇİN; Halil KÖMEK; Abdurrahman IŞIKDOĞAN

Makale detayları

The Effect of Metabolic PET Parameters on Survival Outcome in Malignant Pleural Mesothelioma

Yazarlar:

Nadiye AKDENİZ | Mehmet KÜÇÜKÖNER | Muhammet Ali KAPLAN | Zuhat URAKÇI | Oğur KARHAN | Halis YERLİKAYA | Şahin LAÇİN | Halil KÖMEK | Abdurrahman IŞIKDOĞAN

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Dicle Medical Journal 2020 Vol.47 Issue 1, pp.16-23

Belge Tipi:

Makale

Yayın Tarihi:

3/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000946549

Sıklık:

Üç Aylık

eISSN:

1308-9889

pISSN:

1300-2945

Anahtar kelimeler:

Özet:

 

Objective: 18-Fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) is one of the most valuable imaging types and tumor metabolic volume is another parameter that can be obtained from PET-CT. Our primary objective is to evaluate the effect of PET-CT metabolic parameters on survival in patients with malignant pleural mesothelioma (MPM).
Methods: A total of 29 patients with MPM had been evaluated with 18F-FDG PET-CT between January 2016 and December 2017. Metabolic tumor volume (MTV), total lesion glycolysis (TLG), standardized uptake values (SUVmax) and TLG/liver SUVmean values were calculated. Also, effects of these parameters on survival rates were evaluated.
Results: Histological subtypes of the disease were determined as epithelioid (n=24), biphasic (n=3), sarcomatoid (n=2). Median overall survival was 255 days (21-903). Median MTV was 225 cm³ (10-1879), median TLG was 1056 g/ml*cm³ (36-18927), median SUVmax was 7.7 (1.5-20) and TLG/liver SUVmean ratio was 561.2 (14.9-8113.7). Sensitivity and specificity for MTV 113 cut-off value were 86.4% and 85.7%, respectively. Determined cut-off value for TLG was 419.5, sensitivity and specificity of the value were 81.8% and 85.7%, respectively. Additionally, determined cut-off value for TLG/liver SUVmean ratio was 107.4, the rate of sensitivity and specificity for this value were 95.5% and 71.4%, respectively. The patients with higher MTV, TLG and TLG/liver SUVmean had worse survival rate. 
Conclusion: We confirmed significant association between MTV, TLG and TLG/liver SUVmean values and patients survival. These promising PET derived parameters can be used for evaluating treatment response and prognosis in MPM.

Makale detayları

The Effect of Metabolic PET Parameters on Survival Outcome in Malignant Pleural Mesothelioma

Yazarlar:

Nadiye AKDENİZ | Mehmet KÜÇÜKÖNER | Muhammet Ali KAPLAN | Zuhat URAKÇI | Oğur KARHAN | Halis YERLİKAYA | Şahin LAÇİN | Halil KÖMEK | Abdurrahman IŞIKDOĞAN

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Dicle Medical Journal 2020 Vol.47 Issue 1, pp.16-23

Belge Tipi:

Makale

Yayın Tarihi:

3/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000946549

Sıklık:

Üç Aylık

eISSN:

1308-9889

pISSN:

1300-2945

Malignant pleural mesothelioma

survival

FDG PET/CT

Sayı

Makale detayları

The Effect of Metabolic PET Parameters on Survival Outcome in Malignant Pleural Mesothelioma

Yazarlar: Nadiye AKDENİZ | Mehmet KÜÇÜKÖNER | Muhammet Ali KAPLAN | Zuhat URAKÇI | Oğur KARHAN | Halis YERLİKAYA | Şahin LAÇİN | Halil KÖMEK | Abdurrahman IŞIKDOĞAN

Yayıncı: Dicle University

Ana Başlıklar: Sağlık teşvikleri

Dergi: Dicle Medical Journal 2020 Vol.47 Issue 1, pp.16-23

Belge Tipi: Makale

Yayın Tarihi: 3/2020

Belge Dili: İngilizce

Document ID (Org No.): 2000946549

Sıklık: Üç Aylık

eISSN: 1308-9889

pISSN: 1300-2945

Malignant pleural mesothelioma

survival

FDG PET/CT

Sayı

Yazarlar:

Nadiye AKDENİZ | Mehmet KÜÇÜKÖNER | Muhammet Ali KAPLAN | Zuhat URAKÇI | Oğur KARHAN | Halis YERLİKAYA | Şahin LAÇİN | Halil KÖMEK | Abdurrahman IŞIKDOĞAN

Yayıncı:

Dicle University

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

Dicle Medical Journal 2020 Vol.47 Issue 1, pp.16-23

Belge Tipi:

Makale

Yayın Tarihi:

3/2020

Belge Dili:

İngilizce

Document ID (Org No.):

2000946549

Sıklık:

Üç Aylık

eISSN:

1308-9889

pISSN:

1300-2945