Effects of Potassium Dichromate and Boron on Oxidative Stress and DNA Damage in Rats

Meryem Eren; Meryem Şentürk

Makale detayları

Effects of Potassium Dichromate and Boron on Oxidative Stress and DNA Damage in Rats

Yazarlar:

Meryem Eren | Meryem Şentürk

Yayıncı:

Erciyes University

Ana Başlıklar:

Veteriner Biyokimya

Dergi:

Erciyes Üniversitesi Veteriner Fakültesi Dergisi Vol.21 Issue 3, pp.162-167

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001332603

pISSN:

1304-7280

Anahtar kelimeler:

Özet:

 In this study, the effects of potassium dichromate K2Cr2O7 and boron B, as boric acid on oxidative stress and DNA damage in rat serum and liver were investigated. Sixty female Sprague-Dawley rats were divided into six groups of 10 animals each. The first group was kept as the control group. The second and third groups received 5 and 10 mgkg B, respectively, the forth group received 10 mgkg K2Cr2O7, and the fifth and sixth groups received 5 and 10 mgkg B plus K2Cr2O7, respectively, orally for two weeks. Compared with the control groups, serum MDA levels increased P0.01 and TAC levels decreased P0.001 in the K2Cr2O7 group. Serum MDA levels decreased in the K2Cr2O75 and 10 mgkg B groups, but a significant decrease was found in the K2Cr2O710 mgkg B group P0.01. Serum TAC levels showed a numerical increase in K2Cr2O7B groups. The liver MDA level was significantly decreased in the K2Cr2O710 mgkg B group compared to the other groups P0.01. There was no difference in plasma 8-OHdG levels between the groups. A positive correlation was observed between liver B and Cr levels P0.05. In this study, serum MDA and TAC levels were negatively affected in rats administered 10 mgkg K2Cr2O7. In contrast, administration of 10 mgkg B to the K2Cr2O7 group had positively effected on serum and liver lipid peroxidation indicators.

 In this study, the effects of potassium dichromate K2Cr2O7 and boron B, as boric acid on oxidative stress and DNA damage in rat serum and liver were investigated. Sixty female Sprague-Dawley rats were divided into six groups of 10 animals each. The first group was kept as the control group. The second and third groups received 5 and 10 mgkg B, respectively, the forth group received 10 mgkg K2Cr2O7, and the fifth and sixth groups received 5 and 10 mgkg B plus K2Cr2O7, respectively, orally for two weeks. Compared with the control groups, serum MDA levels increased P0.01 and TAC levels decreased P0.001 in the K2Cr2O7 group. Serum MDA levels decreased in the K2Cr2O75 and 10 mgkg B groups, but a significant decrease was found in the K2Cr2O710 mgkg B group P0.01. Serum TAC levels showed a numerical increase in K2Cr2O7B groups. The liver MDA level was significantly decreased in the K2Cr2O710 mgkg B group compared to the other groups P0.01. There was no difference in plasma 8-OHdG levels between the groups. A positive correlation was observed between liver B and Cr levels P0.05. In this study, serum MDA and TAC levels were negatively affected in rats administered 10 mgkg K2Cr2O7. In contrast, administration of 10 mgkg B to the K2Cr2O7 group had positively effected on serum and liver lipid peroxidation indicators.

 In this study, the effects of potassium dichromate K2Cr2O7 and boron B, as boric acid on oxidative stress and DNA damage in rat serum and liver were investigated. Sixty female Sprague-Dawley rats were divided into six groups of 10 animals each. The first group was kept as the control group. The second and third groups received 5 and 10 mgkg B, respectively, the forth group received 10 mgkg K2Cr2O7, and the fifth and sixth groups received 5 and 10 mgkg B plus K2Cr2O7, respectively, orally for two weeks. Compared with the control groups, serum MDA levels increased P0.01 and TAC levels decreased P0.001 in the K2Cr2O7 group. Serum MDA levels decreased in the K2Cr2O75 and 10 mgkg B groups, but a significant decrease was found in the K2Cr2O710 mgkg B group P0.01. Serum TAC levels showed a numerical increase in K2Cr2O7B groups. The liver MDA level was significantly decreased in the K2Cr2O710 mgkg B group compared to the other groups P0.01. There was no difference in plasma 8-OHdG levels between the groups. A positive correlation was observed between liver B and Cr levels P0.05. In this study, serum MDA and TAC levels were negatively affected in rats administered 10 mgkg K2Cr2O7. In contrast, administration of 10 mgkg B to the K2Cr2O7 group had positively effected on serum and liver lipid peroxidation indicators.

 Bu çalışmada, sıçanlarda potasyum dikromat K2Cr2O7 ve borun B, borik asit olarak serum ve karaciğer oksidatif stres ve DNA hasarı uzerine etkileri araştırıldı. Altmış dişi Sprague-Dawley sıçan, her birinde 10 hayvan bulunan altı gruba ayrıldı. Birinci grup kontrol grubu olarak tutuldu. İkinci ve uçuncu gruplara sırasıyla 5 ve 10 mgkg B; dörduncu gruba 10 mgkg K2Cr2O7; beş ve altıncı gruplara ise 5 ve 10 mgkg B ile birlikte K2Cr2O7 2 hafta boyunca oral olarak verildi. Kontrol grupları ile karşılaştırıldığında K2Cr2O7 grubunda serum MDA duzeyleri artarken P0.01, TAC duzeyleri azaldı P0.001. Serum MDA duzeyleri K2Cr2O75 ve 10 mgkg B gruplarında azaldı; ancak, anlamlı azalma K2Cr2O710 mgkg B grubunda P0.01 tespit edildi. Serum TAC duzeyleri K2Cr2O7B gruplarında sayısal artış göster-di. Karaciğer MDA duzeyi, K2Cr2O710 mgkg B grubunda diğer gruplara göre anlamlı duzeyde azaldı P0.01. Grup-lar arasında plazma 8-OHdG duzeyleri açısından fark belirlenemedi. Karaciğer B ve Cr duzeyleri arasında pozitif korelasyon saptandı P0.05. Bu çalışmada 10 mgkg K2Cr2O7 uygulanan ratlarda serum MDA ve TAC duzeyleri olumsuz etkilenirken, K2Cr2O7 grubuna 10 mgkg B verilmesi, serum ve karaciğer lipid peroksidasyon göstergeleri uzerine olum-lu etki yaptığı söylenebilir.

Makale detayları

Effects of Potassium Dichromate and Boron on Oxidative Stress and DNA Damage in Rats

Yazarlar:

Meryem Eren | Meryem Şentürk

Yayıncı:

Erciyes University

Ana Başlıklar:

Veteriner Biyokimya

Dergi:

Erciyes Üniversitesi Veteriner Fakültesi Dergisi Vol.21 Issue 3, pp.162-167

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001332603

pISSN:

1304-7280

Boron

DNA damage

oxidative stress

potassium dichromate

ratBor

DNA hasarı

oksidatif stres

potasyum dikromat

rat

Sayı

Makale detayları

Yazarlar: Meryem Eren | Meryem Şentürk

Yayıncı: Erciyes University

Ana Başlıklar: Veteriner Biyokimya

Dergi: Erciyes Üniversitesi Veteriner Fakültesi Dergisi Vol.21 Issue 3, pp.162-167

Belge Tipi: Makale

Yayın Tarihi: 2/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001332603

pISSN: 1304-7280

Sayı

Yazarlar:

Meryem Eren | Meryem Şentürk

Yayıncı:

Erciyes University

Ana Başlıklar:

Veteriner Biyokimya

Dergi:

Erciyes Üniversitesi Veteriner Fakültesi Dergisi Vol.21 Issue 3, pp.162-167

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001332603

pISSN:

1304-7280