Clinical and morphologic features of macular telangiectasia type 2: natural course of the disease

Püren Işık; İlgin Kaya; Ebru Esen; Nihal Demircan; Hülya Binokay

Makale detayları

Clinical and morphologic features of macular telangiectasia type 2: natural course of the disease

Yazarlar:

Püren Işık | İlgin Kaya | Ebru Esen | Nihal Demircan | Hülya Binokay

Yayıncı:

Cukurova University

Ana Başlıklar:

Göz Hastalıkları

Dergi:

Cukurova Medical Journal Vol.49 Issue 3, pp.760-768

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327869

pISSN:

2602-3032

Anahtar kelimeler:

Özet:

 Purpose: The purpose of this study is to report the clinical characteristics of macular telangiectasia type 2 MacTel 2 in a natural disease course. Materials and Methods: A retrospective analysis of patients diagnosed with MacTel 2 over a 4-year period. Best-corrected visual acuity BCVA, fundus photography, and optical coherence tomography OCT images were reviewed. Differences in BCVA, fundoscopic findings, and OCT parameters were compared between the initial and final visits. Results: The study included 28 eyes from 14 patients 11 women, 3 males, with a mean age of 65.5  9.8 years. The mean follow-up period was 55.6  32.9 months. The mean BCVA at baseline and final follow-up were 0.51  0.6 and 0.7  0.62 logMAR, respectively. At the first and last visits, the right-angle venules were the most common fundoscopic finding 78.6 for both. Subretinal neovascularization NV was initially present in two eyes and developed in one eye during follow-up. The mean temporal macular thickness decreased significantly during the follow-up period, while the central and nasal thickness did not show a significant change. At the last visit, focal ellipsoid zone EZ loss was found in 27 eyes 96.4, compared to 24 eyes 85.7 at baseline. External limiting membrane ELM loss was found in 23 eyes 82.1 at the first visit and in 25 eyes 89.3 at the final visit. The increase in mean length of the EZ and ELM loss during the follow-up was not statistically significant. Conclusion: Despite the progressive effect of the disease on central visual acuity, it is very important to closely monitor these eyes for the development of secondary NV, which may develop due to degenerative and atrophic changes in the macula.

 Purpose: The purpose of this study is to report the clinical characteristics of macular telangiectasia type 2 MacTel 2 in a natural disease course. Materials and Methods: A retrospective analysis of patients diagnosed with MacTel 2 over a 4-year period. Best-corrected visual acuity BCVA, fundus photography, and optical coherence tomography OCT images were reviewed. Differences in BCVA, fundoscopic findings, and OCT parameters were compared between the initial and final visits. Results: The study included 28 eyes from 14 patients 11 women, 3 males, with a mean age of 65.5  9.8 years. The mean follow-up period was 55.6  32.9 months. The mean BCVA at baseline and final follow-up were 0.51  0.6 and 0.7  0.62 logMAR, respectively. At the first and last visits, the right-angle venules were the most common fundoscopic finding 78.6 for both. Subretinal neovascularization NV was initially present in two eyes and developed in one eye during follow-up. The mean temporal macular thickness decreased significantly during the follow-up period, while the central and nasal thickness did not show a significant change. At the last visit, focal ellipsoid zone EZ loss was found in 27 eyes 96.4, compared to 24 eyes 85.7 at baseline. External limiting membrane ELM loss was found in 23 eyes 82.1 at the first visit and in 25 eyes 89.3 at the final visit. The increase in mean length of the EZ and ELM loss during the follow-up was not statistically significant. Conclusion: Despite the progressive effect of the disease on central visual acuity, it is very important to closely monitor these eyes for the development of secondary NV, which may develop due to degenerative and atrophic changes in the macula.

 Purpose: The purpose of this study is to report the clinical characteristics of macular telangiectasia type 2 MacTel 2 in a natural disease course. Materials and Methods: A retrospective analysis of patients diagnosed with MacTel 2 over a 4-year period. Best-corrected visual acuity BCVA, fundus photography, and optical coherence tomography OCT images were reviewed. Differences in BCVA, fundoscopic findings, and OCT parameters were compared between the initial and final visits. Results: The study included 28 eyes from 14 patients 11 women, 3 males, with a mean age of 65.5  9.8 years. The mean follow-up period was 55.6  32.9 months. The mean BCVA at baseline and final follow-up were 0.51  0.6 and 0.7  0.62 logMAR, respectively. At the first and last visits, the right-angle venules were the most common fundoscopic finding 78.6 for both. Subretinal neovascularization NV was initially present in two eyes and developed in one eye during follow-up. The mean temporal macular thickness decreased significantly during the follow-up period, while the central and nasal thickness did not show a significant change. At the last visit, focal ellipsoid zone EZ loss was found in 27 eyes 96.4, compared to 24 eyes 85.7 at baseline. External limiting membrane ELM loss was found in 23 eyes 82.1 at the first visit and in 25 eyes 89.3 at the final visit. The increase in mean length of the EZ and ELM loss during the follow-up was not statistically significant. Conclusion: Despite the progressive effect of the disease on central visual acuity, it is very important to closely monitor these eyes for the development of secondary NV, which may develop due to degenerative and atrophic changes in the macula.

 Amaç: Bu çalışmanın amacı maküler telenjiektazi tip 2nin MacTel 2 doğal hastalık seyrindeki klinik özelliklerini bildirmektir. Gereç ve Yöntem: MacTel 2 tanılı hastaların 4 yıllık bir süre boyunca en iyi düzeltilmiş görme keskinliği EİDGK, fundus fotoğrafı ve optik koherens tomografi OKT görüntüleri incelenerek retrospektif analizleri yapıldı. EİDGK, fundoskopik bulgular ve OKT parametreleri ilk ve son vizitler arasında karşılaştırıldı. Bulgular: Çalışmaya ortalama yaşı 65,5  9,8 yıl olan 14 hastanın 11 kadın, 3 erkek 28 gözü dahil edildi. Ortalama takip süresi 55,6  32,9 ay idi. Başlangıç ve son vizit ortalama EİDGK sırasıyla 0,51  0,6 ve 0,7  0,62 logMAR idi. İlk ve son vizitlerde, dik açılı venüller en yaygın fundoskopik bulguydu 78,6. Subretinal neovaskülarizasyon NV iki gözde başlangıçta mevcuttu ve takip sırasında bir gözde gelişti. Ortalama temporal makula kalınlığı takip süresi boyunca anlamlı olarak azalırken, santral ve nazal kalınlık da anlamlı bir değişiklik bulunmadı. Başlangıçta 24 gözde 85,7 fokal ellipsoid zon EZ kaybı mevcutken, son vizitte 27 gözde 96,4 saptandı. Dış limitan membran kaybı ilk vizitte 23 gözde 82,1 saptanırken, son vizitte 25 gözde 89,3 mevcuttu. Takip süresince ortalama EZ ve dış limitan membran uzunluğu kaybındaki artış istatistiksel olarak anlamlı bulunmadı. Sonuç: Hastalığın merkezi görme keskinliği üzerindeki ilerleyici etkisine rağmen, bu gözlerin maküladaki dejeneratif ve atrofik değişikliklere bağlı olarak gelişebilecek ikincil NV gelişimi açısından yakından izlenmesi önemlidir.

Makale detayları

Clinical and morphologic features of macular telangiectasia type 2: natural course of the disease

Yazarlar:

Püren Işık | İlgin Kaya | Ebru Esen | Nihal Demircan | Hülya Binokay

Yayıncı:

Cukurova University

Ana Başlıklar:

Göz Hastalıkları

Dergi:

Cukurova Medical Journal Vol.49 Issue 3, pp.760-768

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327869

pISSN:

2602-3032

ellipsoid zone

external limiting membrane

hyporeflective cavitation

macular telangiectasia type 2Dış limitan membran

ellipsoid zon

hiporeflektif kavitasyon

makular telanjiektazi tip-2

Sayı

Makale detayları

Yazarlar: Püren Işık | İlgin Kaya | Ebru Esen | Nihal Demircan | Hülya Binokay

Yayıncı: Cukurova University

Ana Başlıklar: Göz Hastalıkları

Dergi: Cukurova Medical Journal Vol.49 Issue 3, pp.760-768

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001327869

pISSN: 2602-3032

Sayı

Yazarlar:

Püren Işık | İlgin Kaya | Ebru Esen | Nihal Demircan | Hülya Binokay

Yayıncı:

Cukurova University

Ana Başlıklar:

Göz Hastalıkları

Dergi:

Cukurova Medical Journal Vol.49 Issue 3, pp.760-768

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001327869

pISSN:

2602-3032