Diagnostic use of CA 125 values measured on the 2nd and 14th days of the menstrual cycle in endometriosis

Hüseyin Aytuğ AVŞAR; Sefa KURT; Murat CELİLOĞLU; Tunç TİMUR

doi:https://doi.org/10.28982/josam.988164

Makale detayları

Diagnostic use of CA 125 values measured on the 2nd and 14th days of the menstrual cycle in endometriosis

Yazarlar:

Hüseyin Aytuğ AVŞAR | Sefa KURT | Murat CELİLOĞLU | Tunç TİMUR

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Jinekoloji ve diğer tıbbi uzmanlık alanları

Dergi:

Journal of Surgery and Medicine 2022 Vol.6 Issue 5, pp.586-590

Belge Tipi:

Makale

Yayın Tarihi:

4/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000497869

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.988164

Özet:

 

Background/Aim: This study examines the difference of serum CRP and CA 125 levels between the menstrual and non-menstrual phases of the menstrual cycle (days 2 and 14) and aims to investigate the diagnostic value of these markers for the early diagnosis of endometriosis.
Methods: There were 36 patients in the study group and 30 patients in the control group (n = 66) in this prospective case-control study. The patients in the study group, who were prediagnosed with endometriosis, were tested for serum CA 125 and CRP on the 2nd and 14th days of menstrual cycle preoperatively (during menstruation and non-menstrual phase) and underwent surgery. The women in the control group were patients who visited the outpatient clinic for a regular checkup without any gynecological complaints.
Results: The CA 125 levels were significantly higher on the 2nd day of the menstrual cycle than the 14th day in the study group [108.15 (90.33) U/mL and 58.60 (39.53) U/mL, respectively, P < 0.001]. In the control group, the CA 125 levels were also significantly higher on the 2nd day than the 14th day [22.97 (15.42) U/mL and 13.82 (6.82) U/mL, respectively, P < 0.001]. When the comparison was made between the CRP levels on the 2nd and 14th day for the study group [4.52 (4.45) mg/L and 2.82 (3.79) mg/L, respectively], the levels were significantly higher on the 2nd day (P < 0.001). The difference of CA 125 and CRP levels between the days [for the study group: ΔCA 125 = 49.55 (56.89) U/mL, ΔCRP = 1.69 (3.45) mg/L and for the control group ΔCA 125 = 9.14 (11.95) U/mL, ΔCRP = 1.42 (4.74) mg/L] were higher for both markers in the study group, and the differences with the control group were statistically significant (P < 0.001 for ΔCA 125 and P = 0.033 for ΔCRP).
Conclusion: Our data indicates that it may be possible to support the diagnosis with the evaluation of CA 125 levels during different phases of menstruation separately.

Makale detayları

Diagnostic use of CA 125 values measured on the 2nd and 14th days of the menstrual cycle in endometriosis

Yazarlar: Hüseyin Aytuğ AVŞAR | Sefa KURT | Murat CELİLOĞLU | Tunç TİMUR

Yayıncı: Fatih BAŞAK

Ana Başlıklar: Jinekoloji ve diğer tıbbi uzmanlık alanları

Dergi: Journal of Surgery and Medicine 2022 Vol.6 Issue 5, pp.586-590

Belge Tipi: Makale

Yayın Tarihi: 4/2022

Belge Dili: İngilizce

Document ID (Org No.): 2000497869

Sıklık: Aylık

eISSN: 2602-2079

DOI: https://doi.org/10.28982/josam.988164

Sayı

Yazarlar:

Hüseyin Aytuğ AVŞAR | Sefa KURT | Murat CELİLOĞLU | Tunç TİMUR

Yayıncı:

Fatih BAŞAK

Ana Başlıklar:

Jinekoloji ve diğer tıbbi uzmanlık alanları

Dergi:

Journal of Surgery and Medicine 2022 Vol.6 Issue 5, pp.586-590

Belge Tipi:

Makale

Yayın Tarihi:

4/2022

Belge Dili:

İngilizce

Document ID (Org No.):

2000497869

Sıklık:

Aylık

eISSN:

2602-2079

DOI:

https://doi.org/10.28982/josam.988164