Synthesis, Characterization, of Antioxidant Activity Mannich Bases from 2-Benzoxalinones

Faika Başoğlu; Eda Becer; Tugba Ercetin; Hayrettin Ozan Gülcan

Makale detayları

Synthesis, Characterization, of Antioxidant Activity Mannich Bases from 2-Benzoxalinones

Yazarlar:

Faika Başoğlu | Eda Becer | Tugba Ercetin | Hayrettin Ozan Gülcan

Yayıncı:

Giresun University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Karadeniz Fen Bilimleri Dergisi Vol.14 Issue 4, pp.2143-2152

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001333419

pISSN:

2564-7377

Anahtar kelimeler:

Özet:

 This study aimed to synthesize a series of 3-substituted piperazinomethyl derivatives BzO1-4 via a Mannich reaction and evaluate their antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging activity and ferrous ion- chelation capacity assays. The synthesis process involved precise techniques, and the compounds were characterized using elemental analysis, FT-IR, and 1H-NMR spectroscopy. Notably, BzO-1, featuring a 4-methylphenyl substituent, emerged as a novel compound within this series, demonstrating the highest antioxidant activity among the four derivatives tested. A considarable performance of BzO-1 was evident in its ability to neutralize free radicals and ferric ion-chelating capacity indicating its potential as a potent antioxidant agent. The detailed characterization data provided insights into the molecular structures and electronic environments of the synthesized compounds, which were crucial for understanding their antioxidant mechanisms. These findings suggest that the structural modifications in these piperazinomethyl derivatives significantly influence their antioxidant properties, and the novel BzO-1 compound holds promise for further development and application in antioxidant therapy.

 This study aimed to synthesize a series of 3-substituted piperazinomethyl derivatives BzO1-4 via a Mannich reaction and evaluate their antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging activity and ferrous ion- chelation capacity assays. The synthesis process involved precise techniques, and the compounds were characterized using elemental analysis, FT-IR, and 1H-NMR spectroscopy. Notably, BzO-1, featuring a 4-methylphenyl substituent, emerged as a novel compound within this series, demonstrating the highest antioxidant activity among the four derivatives tested. A considarable performance of BzO-1 was evident in its ability to neutralize free radicals and ferric ion-chelating capacity indicating its potential as a potent antioxidant agent. The detailed characterization data provided insights into the molecular structures and electronic environments of the synthesized compounds, which were crucial for understanding their antioxidant mechanisms. These findings suggest that the structural modifications in these piperazinomethyl derivatives significantly influence their antioxidant properties, and the novel BzO-1 compound holds promise for further development and application in antioxidant therapy.

 This study aimed to synthesize a series of 3-substituted piperazinomethyl derivatives BzO1-4 via a Mannich reaction and evaluate their antioxidant activities using 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging activity and ferrous ion- chelation capacity assays. The synthesis process involved precise techniques, and the compounds were characterized using elemental analysis, FT-IR, and 1H-NMR spectroscopy. Notably, BzO-1, featuring a 4-methylphenyl substituent, emerged as a novel compound within this series, demonstrating the highest antioxidant activity among the four derivatives tested. A considarable performance of BzO-1 was evident in its ability to neutralize free radicals and ferric ion-chelating capacity indicating its potential as a potent antioxidant agent. The detailed characterization data provided insights into the molecular structures and electronic environments of the synthesized compounds, which were crucial for understanding their antioxidant mechanisms. These findings suggest that the structural modifications in these piperazinomethyl derivatives significantly influence their antioxidant properties, and the novel BzO-1 compound holds promise for further development and application in antioxidant therapy.

 Bu çalışma, bir dizi 3-ikameli piperazinometil türevini BzO1-4 bir Mannich reaksiyonu yoluyla sentezlemeyi ve 2,2-difenil-1-pikrilhidrazil DPPH radikal süpürücü aktivitesi ve demir iyonu şelasyon kapasitesi analizleri kullanarak antioksidan aktivitelerini değerlendirmeyi amaçlamıştır. Sentez süreci hassas teknikler içermiştir ve bileşikler element analizi, FT-IR ve 1H-NMR spektroskopisi kullanılarak karakterize edilmiştir. Özellikle, 4-metilfenil ikamesi içeren BzO-1, bu seride yeni bir bileşik olarak ortaya çıkmış ve test edilen dört türev arasında en yüksek antioksidan aktiviteyi göstermiştir. BzO-1in serbest radikalleri nötralize etme, demir iyonlarını şelatlama yeteneğinde önemli bir performansın olduğu ortaya çıkmış ve bu da onun güçlü bir antioksidan ajan olarak potansiyelini göstermiştir. Ayrıntılı karakterizasyon verileri, antioksidan mekanizmalarını anlamak için çok önemli olan sentezlenen bileşiklerin moleküler yapıları ve elektronik ortamları hakkında bilgi sağlamıştır. Bu bulgular, piperazinometil türevlerindeki yapısal değişikliklerin antioksidan özelliklerini önemli ölçüde etkilediğini ve yeni BzO-1 bileşiğinin antioksidan tedavide daha fazla geliştirilme ve uygulama için umut vaat ettiğini göstermektedir.

Makale detayları

Synthesis, Characterization, of Antioxidant Activity Mannich Bases from 2-Benzoxalinones

Yazarlar:

Faika Başoğlu | Eda Becer | Tugba Ercetin | Hayrettin Ozan Gülcan

Yayıncı:

Giresun University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Karadeniz Fen Bilimleri Dergisi Vol.14 Issue 4, pp.2143-2152

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001333419

pISSN:

2564-7377

Mannich reaction

1

3-benzoxazole

antioxidantMannich reaction

1

3-benzoxazole

antioxidant

Sayı

Makale detayları

Yazarlar: Faika Başoğlu | Eda Becer | Tugba Ercetin | Hayrettin Ozan Gülcan

Yayıncı: Giresun University

Ana Başlıklar: Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi: Karadeniz Fen Bilimleri Dergisi Vol.14 Issue 4, pp.2143-2152

Belge Tipi: Makale

Yayın Tarihi: 12/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001333419

pISSN: 2564-7377

Sayı

Yazarlar:

Faika Başoğlu | Eda Becer | Tugba Ercetin | Hayrettin Ozan Gülcan

Yayıncı:

Giresun University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Karadeniz Fen Bilimleri Dergisi Vol.14 Issue 4, pp.2143-2152

Belge Tipi:

Makale

Yayın Tarihi:

12/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001333419

pISSN:

2564-7377