A new prognostic marker in small cell lung cancer: red cell distribution width ratio of hemoglobin

Figen Öztürk Ergür; Ayperi Öztürk

Makale detayları

A new prognostic marker in small cell lung cancer: red cell distribution width ratio of hemoglobin

Yazarlar:

Figen Öztürk Ergür | Ayperi Öztürk

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 2, pp.148-152

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286204

pISSN:

2718-0115

Anahtar kelimeler:

Özet:

 Aim: The ratio of hemoglobin Hb to red cell distribution width RDW HRR has been defined as an effective prognostic factor in various cancer types. The aim of this study is to investigate the prognostic role of HRR value in small cell lung cancer SCLC. Material and Method: A total of 1039 patients diagnosed with SCLC between 2010-2021 were included in the study. After exclusion of 199 patients without positron emission tomography-computerized tomography PET-CT, age, gender, additional disease histories, smoking history, pathological stages, survival status, disease progression times, treatments applied, first hemoglobin obtained after diagnosis, red cell distribution width and ratios, and other laboratory parameters of 840 patients were recorded. The log-rank test and the Cox proportional hazards model were used to identify predictors of mortality. Results: A total of 840 patients were included in the study. The median overall survival OS and the progression-free survival PS times of the patients were 9 months, and 7 months, respectively. The cut-off value for HRR was determined 0.580 sensitivity 78.73, specificity 37.88. In this study, each one-unit increase in HRR reduces death and survival by 1.6 times detected, and it was revealed that HRR had a statistically significant effect on OS and PS. When the patients were divided into two as limited and extensive disease, there was a statistically significant difference between the groups in terms of OS 12-6 months and PS 10-6 months, but no significant difference was found in terms of HRR between these two groups. Conclusion: HRR is an easily accessible, inexpensive parameter that can be used as a prognostic marker in patients with SCLC.

 Aim: The ratio of hemoglobin Hb to red cell distribution width RDW HRR has been defined as an effective prognostic factor in various cancer types. The aim of this study is to investigate the prognostic role of HRR value in small cell lung cancer SCLC. Material and Method: A total of 1039 patients diagnosed with SCLC between 2010-2021 were included in the study. After exclusion of 199 patients without positron emission tomography-computerized tomography PET-CT, age, gender, additional disease histories, smoking history, pathological stages, survival status, disease progression times, treatments applied, first hemoglobin obtained after diagnosis, red cell distribution width and ratios, and other laboratory parameters of 840 patients were recorded. The log-rank test and the Cox proportional hazards model were used to identify predictors of mortality. Results: A total of 840 patients were included in the study. The median overall survival OS and the progression-free survival PS times of the patients were 9 months, and 7 months, respectively. The cut-off value for HRR was determined 0.580 sensitivity 78.73, specificity 37.88. In this study, each one-unit increase in HRR reduces death and survival by 1.6 times detected, and it was revealed that HRR had a statistically significant effect on OS and PS. When the patients were divided into two as limited and extensive disease, there was a statistically significant difference between the groups in terms of OS 12-6 months and PS 10-6 months, but no significant difference was found in terms of HRR between these two groups. Conclusion: HRR is an easily accessible, inexpensive parameter that can be used as a prognostic marker in patients with SCLC.

 Aim: The ratio of hemoglobin Hb to red cell distribution width RDW HRR has been defined as an effective prognostic factor in various cancer types. The aim of this study is to investigate the prognostic role of HRR value in small cell lung cancer SCLC. Material and Method: A total of 1039 patients diagnosed with SCLC between 2010-2021 were included in the study. After exclusion of 199 patients without positron emission tomography-computerized tomography PET-CT, age, gender, additional disease histories, smoking history, pathological stages, survival status, disease progression times, treatments applied, first hemoglobin obtained after diagnosis, red cell distribution width and ratios, and other laboratory parameters of 840 patients were recorded. The log-rank test and the Cox proportional hazards model were used to identify predictors of mortality. Results: A total of 840 patients were included in the study. The median overall survival OS and the progression-free survival PS times of the patients were 9 months, and 7 months, respectively. The cut-off value for HRR was determined 0.580 sensitivity 78.73, specificity 37.88. In this study, each one-unit increase in HRR reduces death and survival by 1.6 times detected, and it was revealed that HRR had a statistically significant effect on OS and PS. When the patients were divided into two as limited and extensive disease, there was a statistically significant difference between the groups in terms of OS 12-6 months and PS 10-6 months, but no significant difference was found in terms of HRR between these two groups. Conclusion: HRR is an easily accessible, inexpensive parameter that can be used as a prognostic marker in patients with SCLC.

 Aim: The ratio of hemoglobin Hb to red cell distribution width RDW HRR has been defined as an effective prognostic factor in various cancer types. The aim of this study is to investigate the prognostic role of HRR value in small cell lung cancer SCLC. Material and Method: A total of 1039 patients diagnosed with SCLC between 2010-2021 were included in the study. After exclusion of 199 patients without positron emission tomography-computerized tomography PET-CT, age, gender, additional disease histories, smoking history, pathological stages, survival status, disease progression times, treatments applied, first hemoglobin obtained after diagnosis, red cell distribution width and ratios, and other laboratory parameters of 840 patients were recorded. The log-rank test and the Cox proportional hazards model were used to identify predictors of mortality. Results: A total of 840 patients were included in the study. The median overall survival OS and the progression-free survival PS times of the patients were 9 months, and 7 months, respectively. The cut-off value for HRR was determined 0.580 sensitivity 78.73, specificity 37.88. In this study, each one-unit increase in HRR reduces death and survival by 1.6 times detected, and it was revealed that HRR had a statistically significant effect on OS and PS. When the patients were divided into two as limited and extensive disease, there was a statistically significant difference between the groups in terms of OS 12-6 months and PS 10-6 months, but no significant difference was found in terms of HRR between these two groups. Conclusion: HRR is an easily accessible, inexpensive parameter that can be used as a prognostic marker in patients with SCLC.

Makale detayları

A new prognostic marker in small cell lung cancer: red cell distribution width ratio of hemoglobin

Yazarlar:

Figen Öztürk Ergür | Ayperi Öztürk

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 2, pp.148-152

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286204

pISSN:

2718-0115

HRR

SCLC

survival

prognosis

Sayı

Makale detayları

A new prognostic marker in small cell lung cancer: red cell distribution width ratio of hemoglobin

Yazarlar: Figen Öztürk Ergür | Ayperi Öztürk

Yayıncı: MediHealth Academy Yayıncılık

Ana Başlıklar: Sağlık Kurumları Yönetimi

Dergi: Anatolian Current Medical Journal Vol.5 Issue 2, pp.148-152

Belge Tipi: Makale

Yayın Tarihi: 3/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001286204

pISSN: 2718-0115

HRR

SCLC

survival

prognosis

Sayı

Yazarlar:

Figen Öztürk Ergür | Ayperi Öztürk

Yayıncı:

MediHealth Academy Yayıncılık

Ana Başlıklar:

Sağlık Kurumları Yönetimi

Dergi:

Anatolian Current Medical Journal Vol.5 Issue 2, pp.148-152

Belge Tipi:

Makale

Yayın Tarihi:

3/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001286204

pISSN:

2718-0115