The efficiency of low-dose hepatitis B immunoglobulin plus nucleos(t)ide analogs in preventing posttransplant hepatitis B virus recurrence

Sezgin VATANSEVER; Rasim FERECOV; Hüseyin Cahit YILMAZ; Murat ZEYTUNLU; Murat KILIÇ

Makale detayları

The efficiency of low-dose hepatitis B immunoglobulin plus nucleos(t)ide analogs in preventing posttransplant hepatitis B virus recurrence

Yazarlar:

Sezgin VATANSEVER | Rasim FERECOV | Hüseyin Cahit YILMAZ | Murat ZEYTUNLU | Murat KILIÇ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1019-1024

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749963

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: In this study, the efficiency of using low-dose hepatitis B immunoglobulin (HBIG) plus antiviral treatment according to individual needs has been evaluated in posttransplant hepatitis B virus (HBV) patients.Materials  and  methods:  We  retrospectively  evaluated  179  patients  who  were  admitted  between  2009  and  2014.  Five  thousand  IU  intravenous HBIG was given in the anhepatic phase, and 400 IU/day intramuscular (IM) HBIG was given in the posttransplant period. After HBsAg seroconversion, 400 IU IM HBIG was continued as prophylaxis every two weeks.Results:  The  average  follow-up  period  was  26  (2-65)  months.  Seventy  patients  had  hepatocellular  carcinoma  (HCC).  The  HBV  recurrence was 4.5% in the first year, and 5.8% in the third year. The HBsAg became negative in 11 (2-63) days, and anti-HBs became positive in 9 (1-31) days. HBsAg positivity occurred in 6 patients during the follow-up period. Five of these patients were those who underwent transplantation due to HCC. In 5 of the HCC patients, in whom HBsAg became positive, tumor recurrence was observed after 0.3-9.9 months. HBsAg positivity was more frequently detected in patients with HCC (P = 0.009).Conclusion: The HBV recurrence should be evaluated as a predictor of the HCC recurrence in patients who were transplanted due to HCC.

Makale detayları

The efficiency of low-dose hepatitis B immunoglobulin plus nucleos(t)ide analogs in preventing posttransplant hepatitis B virus recurrence

Yazarlar: Sezgin VATANSEVER | Rasim FERECOV | Hüseyin Cahit YILMAZ | Murat ZEYTUNLU | Murat KILIÇ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1019-1024

Belge Tipi: Makale

Yayın Tarihi: 7/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749963

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Sezgin VATANSEVER | Rasim FERECOV | Hüseyin Cahit YILMAZ | Murat ZEYTUNLU | Murat KILIÇ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 4, pp.1019-1024

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749963

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144