The relationship between systemic immune inflammation index and disease activity in ankylosing spondylitis patients

Büşra Şirin Ahısha; Nur Kesiktaş; Nurdan Paker; Yiğit Can Ahısha

Makale detayları

The relationship between systemic immune inflammation index and disease activity in ankylosing spondylitis patients

Yazarlar:

Büşra Şirin Ahısha | Nur Kesiktaş | Nurdan Paker | Yiğit Can Ahısha

Yayıncı:

Pamukkale University

Ana Başlıklar:

Romatoloji ve Artrit

Dergi:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.197-205

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001318843

pISSN:

1308-0865

Anahtar kelimeler:

Özet:

 Purpose: This study aimed to investigate the relationship between the systemic immune inflammation index SII, platelet-to-lymphocyte ratio PLR, neutrophil-to-lymphocyte ratio NLR, and disease activity and functional status in patients with ankylosing spondylitis AS. Materials and methods: This cross-sectional clinical study included a total of 90 patients diagnosed with AS according to the Modified New York Criteria, aged between 18 and 65, who presented to our outpatient clinics. Demographic data and laboratory parameters, including platelet, neutrophil, basophil, eosinophil, and lymphocyte counts, mean platelet volume MPV, red blood cell distribution width RDW, C-reactive protein CRP, and erythrocyte sedimentation rate ESR, were recorded. NLR and PLR values were calculated. The SII was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count. Results: The study included 90 AS patients mean age: 42.911.3 years. Positive correlations were observed between SII and CRP p0.010, r0.269 and ESR p0.007, r0.282. No significant correlations were found between SII and BASDAI p0.323, BASFI p0.124 or BASMI p0.673. NLR and PLR values didnt differ significantly between active and inactive disease groups across all disease activity measures BASDAI, ASDASCRP, and ASDAS-ESR; NLR: p0.933, p0.639, p0.240; PLR: p0.708, p0.858, p0.351; respectively. There was a significant correlation between SII and Ankylosing Spondylitis Disease Activity Score with erythrocyte sedimentation rate ASDAS-ESR rho0.282, p0.007. Conclusion: The study suggests that SII correlates positively with CRP and ESR, common inflammatory markers in AS. SII could be a potential marker for assessing inflammation, especially in patients with higher disease activity.

 Purpose: This study aimed to investigate the relationship between the systemic immune inflammation index SII, platelet-to-lymphocyte ratio PLR, neutrophil-to-lymphocyte ratio NLR, and disease activity and functional status in patients with ankylosing spondylitis AS. Materials and methods: This cross-sectional clinical study included a total of 90 patients diagnosed with AS according to the Modified New York Criteria, aged between 18 and 65, who presented to our outpatient clinics. Demographic data and laboratory parameters, including platelet, neutrophil, basophil, eosinophil, and lymphocyte counts, mean platelet volume MPV, red blood cell distribution width RDW, C-reactive protein CRP, and erythrocyte sedimentation rate ESR, were recorded. NLR and PLR values were calculated. The SII was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count. Results: The study included 90 AS patients mean age: 42.911.3 years. Positive correlations were observed between SII and CRP p0.010, r0.269 and ESR p0.007, r0.282. No significant correlations were found between SII and BASDAI p0.323, BASFI p0.124 or BASMI p0.673. NLR and PLR values didnt differ significantly between active and inactive disease groups across all disease activity measures BASDAI, ASDASCRP, and ASDAS-ESR; NLR: p0.933, p0.639, p0.240; PLR: p0.708, p0.858, p0.351; respectively. There was a significant correlation between SII and Ankylosing Spondylitis Disease Activity Score with erythrocyte sedimentation rate ASDAS-ESR rho0.282, p0.007. Conclusion: The study suggests that SII correlates positively with CRP and ESR, common inflammatory markers in AS. SII could be a potential marker for assessing inflammation, especially in patients with higher disease activity.

 Purpose: This study aimed to investigate the relationship between the systemic immune inflammation index SII, platelet-to-lymphocyte ratio PLR, neutrophil-to-lymphocyte ratio NLR, and disease activity and functional status in patients with ankylosing spondylitis AS. Materials and methods: This cross-sectional clinical study included a total of 90 patients diagnosed with AS according to the Modified New York Criteria, aged between 18 and 65, who presented to our outpatient clinics. Demographic data and laboratory parameters, including platelet, neutrophil, basophil, eosinophil, and lymphocyte counts, mean platelet volume MPV, red blood cell distribution width RDW, C-reactive protein CRP, and erythrocyte sedimentation rate ESR, were recorded. NLR and PLR values were calculated. The SII was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count. Results: The study included 90 AS patients mean age: 42.911.3 years. Positive correlations were observed between SII and CRP p0.010, r0.269 and ESR p0.007, r0.282. No significant correlations were found between SII and BASDAI p0.323, BASFI p0.124 or BASMI p0.673. NLR and PLR values didnt differ significantly between active and inactive disease groups across all disease activity measures BASDAI, ASDASCRP, and ASDAS-ESR; NLR: p0.933, p0.639, p0.240; PLR: p0.708, p0.858, p0.351; respectively. There was a significant correlation between SII and Ankylosing Spondylitis Disease Activity Score with erythrocyte sedimentation rate ASDAS-ESR rho0.282, p0.007. Conclusion: The study suggests that SII correlates positively with CRP and ESR, common inflammatory markers in AS. SII could be a potential marker for assessing inflammation, especially in patients with higher disease activity.

 Amaç: Bu çalışma, ankilozan spondilit AS hastalarında sistemik immün inflamasyon indeksi SII, trombositlenfosit oranı PLR, nötrofil-lenfosit oranı NLR ile hastalık aktivitesi ve fonksiyonel durum arasındaki ilişkiyi araştırmayı amaçlamaktadır. Gereç ve yöntem: Bu klinik kesitsel çalışmaya, Modifiye New York Kriterlerine göre AS tanısı almış 18- 65 yaş aralığında 90 hasta dahil edildi. Demografik veriler, trombosit, nötrofil, bazofil, eozinofil ve lenfosit sayıları, ortalama trombosit hacmi MPV, eritrosit dağılım genişliği RDW, C-reaktif protein CRP ve eritrosit sedimantasyon hızı ESR gibi laboratuvar parametreleri kaydedildi. NLR, PLR ve SII değerleri hesaplandı. Bulgular: Çalışmaya dahil edilen AS hastalarının yaş ortalamaları 42,911,3 yıl idi. SII ile CRP p0,010, r0,269 ve ESR p0,007, r0,282 arasında pozitif korelasyon saptandı. SII ile BASDAI p0,323, BASFI p0,124 veya BASMI p0,673 arasında anlamlı bir ilişki bulunmadı. NLR ve PLR değerleri aktif ve inaktif hastalık grupları arasında anlamlı bir fark göstermedi BASDAI, ASDAS-CRP ve ASDAS-ESR için sırasıyla; NLR: p0,933, p0,639, p0,240; PLR: p0,708, p0,858, p0,351. SII ile ESR kullanılarak hesaplanan Ankilozan Spondilit Hastalık Aktivite Skoru ASDAS-ESR arasında anlamlı bir korelasyon vardı rho0,282, p0,007. Sonuç: Çalışma, SIInin ASde yaygın inflamatuar belirteçler olan CRP ve ESR ile pozitif korelasyon gösterdiğini ortaya koymaktadır. SII, özellikle daha yüksek hastalık aktivitesine sahip hastalarda inflamasyonu değerlendirmek için potansiyel bir belirteç olabilir.

Makale detayları

The relationship between systemic immune inflammation index and disease activity in ankylosing spondylitis patients

Yazarlar:

Büşra Şirin Ahısha | Nur Kesiktaş | Nurdan Paker | Yiğit Can Ahısha

Yayıncı:

Pamukkale University

Ana Başlıklar:

Romatoloji ve Artrit

Dergi:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.197-205

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001318843

pISSN:

1308-0865

Ankylosing spondylitis

complete blood count

inflammationAnkilozan spondilit

tam kan sayımı

inflamasyon

Sayı

Makale detayları

The relationship between systemic immune inflammation index and disease activity in ankylosing spondylitis patients

Yazarlar: Büşra Şirin Ahısha | Nur Kesiktaş | Nurdan Paker | Yiğit Can Ahısha

Yayıncı: Pamukkale University

Ana Başlıklar: Romatoloji ve Artrit

Dergi: Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.197-205

Belge Tipi: Makale

Yayın Tarihi: 1/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001318843

pISSN: 1308-0865

Ankylosing spondylitis

complete blood count

inflammationAnkilozan spondilit

tam kan sayımı

inflamasyon

Sayı

Yazarlar:

Büşra Şirin Ahısha | Nur Kesiktaş | Nurdan Paker | Yiğit Can Ahısha

Yayıncı:

Pamukkale University

Ana Başlıklar:

Romatoloji ve Artrit

Dergi:

Pamukkale Tıp Dergisi Vol.18 Issue 1, pp.197-205

Belge Tipi:

Makale

Yayın Tarihi:

1/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001318843

pISSN:

1308-0865