Glutamin Enema Might Have Helped Reversing İntestinal Mucosal İnjury Among Diarrheic Calves: Trophic Aminoacid For ‘Microbiota-Gut-Brain Axis’

Deniz Alıç Ural

Makale detayları

Glutamin Enema Might Have Helped Reversing İntestinal Mucosal İnjury Among Diarrheic Calves: Trophic Aminoacid For ‘Microbiota-Gut-Brain Axis’

Yazarlar:

Deniz Alıç Ural

Yayıncı:

Cankiri Karatekin University

Ana Başlıklar:

Naturapati

Dergi:

Avrasya Sağlık Bilimleri Dergisi Vol.8 Issue 3, pp.171-176

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359563

pISSN:

2651-3501

Anahtar kelimeler:

Özet:

 Introduction: Glutamine Gln has been denoted as an effectual nutritional supplementation for improving the gastrointestinal barrier function of animals. Aim: In the present study evaluating the efficacy of Gln on intestinal morphology, as detected by Diamine oxidase dAo, a valuable marker for detecting gastrointestinal toxicity and intestinal mucosal injury, among diarrheic calves. Materials and Methods: In a total of 20 calves with diarrhea, with unknown etiology, were enrolled at this study. Following physical examination performed by board certified veterinary surgeons who were not involved other than technical intervention, rapid diagnostic test kits were applied without any responsible etiological agent detected, a total of 0.9 ml blood was withdrawn from each calf. Sandwich ELISA by use of commercially available bovine dAo test kits were deemed available. Glutamine Gut-cumin I Liquid Sol. was given via rectal route as 15 mgkg for 7 consequtive days. Results: Mean SE dAo ngmL analysis were deemed available at days 0 start of trial and primary end point day 7, presented 9.122.46 vs. 28.193.18 p0,01, respectively. Conclusion: It should not be unwise to draw suggestion that a trophic aminoacid, glutamine, might have helped reversing intestinal mucosal injury among diarrheic calves as detected by dAo levels. Highlights: Glutamine may be a repair molecule and feed additive in intestinal damage.

 Introduction: Glutamine Gln has been denoted as an effectual nutritional supplementation for improving the gastrointestinal barrier function of animals. Aim: In the present study evaluating the efficacy of Gln on intestinal morphology, as detected by Diamine oxidase dAo, a valuable marker for detecting gastrointestinal toxicity and intestinal mucosal injury, among diarrheic calves. Materials and Methods: In a total of 20 calves with diarrhea, with unknown etiology, were enrolled at this study. Following physical examination performed by board certified veterinary surgeons who were not involved other than technical intervention, rapid diagnostic test kits were applied without any responsible etiological agent detected, a total of 0.9 ml blood was withdrawn from each calf. Sandwich ELISA by use of commercially available bovine dAo test kits were deemed available. Glutamine Gut-cumin I Liquid Sol. was given via rectal route as 15 mgkg for 7 consequtive days. Results: Mean SE dAo ngmL analysis were deemed available at days 0 start of trial and primary end point day 7, presented 9.122.46 vs. 28.193.18 p0,01, respectively. Conclusion: It should not be unwise to draw suggestion that a trophic aminoacid, glutamine, might have helped reversing intestinal mucosal injury among diarrheic calves as detected by dAo levels. Highlights: Glutamine may be a repair molecule and feed additive in intestinal damage.

 Introduction: Glutamine Gln has been denoted as an effectual nutritional supplementation for improving the gastrointestinal barrier function of animals. Aim: In the present study evaluating the efficacy of Gln on intestinal morphology, as detected by Diamine oxidase dAo, a valuable marker for detecting gastrointestinal toxicity and intestinal mucosal injury, among diarrheic calves. Materials and Methods: In a total of 20 calves with diarrhea, with unknown etiology, were enrolled at this study. Following physical examination performed by board certified veterinary surgeons who were not involved other than technical intervention, rapid diagnostic test kits were applied without any responsible etiological agent detected, a total of 0.9 ml blood was withdrawn from each calf. Sandwich ELISA by use of commercially available bovine dAo test kits were deemed available. Glutamine Gut-cumin I Liquid Sol. was given via rectal route as 15 mgkg for 7 consequtive days. Results: Mean SE dAo ngmL analysis were deemed available at days 0 start of trial and primary end point day 7, presented 9.122.46 vs. 28.193.18 p0,01, respectively. Conclusion: It should not be unwise to draw suggestion that a trophic aminoacid, glutamine, might have helped reversing intestinal mucosal injury among diarrheic calves as detected by dAo levels. Highlights: Glutamine may be a repair molecule and feed additive in intestinal damage.

 Giriş: Glutamin Gln, hayvanların gastrointestinal bariyer fonksiyonunu iyileştirmek için etkili bir besin takviyesi olarak gösterilmiştir. Amaç: Bu çalışmada, ishalli buzağılarda gastrointestinal toksisite ve intestinal mukozal hasarı tespit etmek için değerli bir belirteç olan Diamin oksidaz dAo ile tespit edilen intestinal morfoloji üzerindeki Glnnin etkinliği değerlendirilmiştir. Materyal ve Metot: Etiyolojisi bilinmeyen toplam 20 buzağı bu çalışmaya dahil edildi. Teknik müdahale dışında herhangi bir müdahalede bulunmayan kurul onaylı veteriner cerrahlar tarafından yapılan fiziksel muayenenin ardından, herhangi bir sorumlu etiyolojik ajan tespit edilmeden hızlı tanı test kitleri uygulandı ve her buzağıdan toplam 0,9 ml kan alındı. Ticari olarak temin edilebilen sığır dAo test kitleri kullanılarak sandviç ELISAnın mevcut olduğu kabul edildi. Bulgular: Glutamin Gut-cumin I Liquid Sol. 7 ardışık gün boyunca rektal yoldan 15 mgkg olarak verildi. Ortalama SE dAo ngmL analizi 0. günde denemenin başlangıcı ve birincil son noktada 7. gün mevcut kabul edildi, sırasıyla 9,122,46ya karşı 28,193,18 p0,01 sunuldu. Sonuç: dAo seviyeleriyle tespit edildiği gibi, ishalli buzağılarda bağırsak mukozal hasarının tersine çevrilmesine yardımcı olabilecek bir trofik aminoasit olan glutaminin önerilmesi akıllıca olmamalıdır. Öne Çıkanlar: Glutamin bağırsak hasarında tamir edici bir molekül ve yem katkı maddesi olabilir.

Makale detayları

Glutamin Enema Might Have Helped Reversing İntestinal Mucosal İnjury Among Diarrheic Calves: Trophic Aminoacid For ‘Microbiota-Gut-Brain Axis’

Yazarlar:

Deniz Alıç Ural

Yayıncı:

Cankiri Karatekin University

Ana Başlıklar:

Naturapati

Dergi:

Avrasya Sağlık Bilimleri Dergisi Vol.8 Issue 3, pp.171-176

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359563

pISSN:

2651-3501

damage

intestine

glutamine

diamine oxidase

diarrheabağırsak

diamin oksidaz

glutamin

hasar

ishal

Sayı

Makale detayları

Yazarlar: Deniz Alıç Ural

Yayıncı: Cankiri Karatekin University

Ana Başlıklar: Naturapati

Dergi: Avrasya Sağlık Bilimleri Dergisi Vol.8 Issue 3, pp.171-176

Belge Tipi: Makale

Yayın Tarihi: 9/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001359563

pISSN: 2651-3501

Sayı

Yazarlar:

Deniz Alıç Ural

Yayıncı:

Cankiri Karatekin University

Ana Başlıklar:

Naturapati

Dergi:

Avrasya Sağlık Bilimleri Dergisi Vol.8 Issue 3, pp.171-176

Belge Tipi:

Makale

Yayın Tarihi:

9/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001359563

pISSN:

2651-3501