Pharmacokinetics of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) Following Administration of Medicated Feed

İdris TÜREL; Gürdal DAĞOĞLU; Orhan YILMAZ

Makale detayları

Pharmacokinetics of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) Following Administration of Medicated Feed

Yazarlar:

İdris TÜREL | Gürdal DAĞOĞLU | Orhan YILMAZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2003 Vol.27 Issue 1, pp.223-227

Belge Tipi:

Makale

Yayın Tarihi:

12/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000770341

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Anahtar kelimeler:

Özet:

 

The pharmacokinetics of oxytetracycline (OTC) were investigated in rainbow trout in freshwater at 10.5 oC. A group of 70 fish received OTC, an intravascular injection (i.v.) of 5 mg/kg body weight. Another group of 105 fish were fed medicated feed containing a dose of 100 mg/kg body weight. OTC plasma concentrations were determined by high performance liquid chromatography. The pharmacokinetic parameters were described by a two-compartment open model giving distribution half-lives of 0.907 h and 16.058 h, and elimination half-lives of 33.5 h and 27 h for i.v. and oral administration of OTC, respectively. After i.v. administration of OTC, other pharmacokinetic parameters estimated were the area under the curve (AUC: 145.078 ± 4.45 mg.ml-1.h-1)  and  mean  residence  time  (MRT: 40.604 ± 1.150 h).  Following  oral  administration, AUC was 34.46 ± 1.189 mg.ml-1.h-1; MRT was 59.272 ± 1.541 h; Cmax was 0.577 mg/ml and Tmax was 36 h. The oral bioavailability (F) of OTC in rainbow trout was found to be only 1.187%.

 

The pharmacokinetics of oxytetracycline (OTC) were investigated in rainbow trout in freshwater at 10.5 oC. A group of 70 fish received OTC, an intravascular injection (i.v.) of 5 mg/kg body weight. Another group of 105 fish were fed medicated feed containing a dose of 100 mg/kg body weight. OTC plasma concentrations were determined by high performance liquid chromatography. The pharmacokinetic parameters were described by a two-compartment open model giving distribution half-lives of 0.907 h and 16.058 h, and elimination half-lives of 33.5 h and 27 h for i.v. and oral administration of OTC, respectively. After i.v. administration of OTC, other pharmacokinetic parameters estimated were the area under the curve (AUC: 145.078 ± 4.45 mg.ml-1.h-1)  and  mean  residence  time  (MRT: 40.604 ± 1.150 h).  Following  oral  administration, AUC was 34.46 ± 1.189 mg.ml-1.h-1; MRT was 59.272 ± 1.541 h; Cmax was 0.577 mg/ml and Tmax was 36 h. The oral bioavailability (F) of OTC in rainbow trout was found to be only 1.187%.

Makale detayları

Pharmacokinetics of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) Following Administration of Medicated Feed

Yazarlar:

İdris TÜREL | Gürdal DAĞOĞLU | Orhan YILMAZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2003 Vol.27 Issue 1, pp.223-227

Belge Tipi:

Makale

Yayın Tarihi:

12/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000770341

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Rainbow trout

oxytetracycline

pharmacokinetic

oral bioavailability

Sayı

Makale detayları

Pharmacokinetics of Oxytetracycline in Rainbow Trout (Oncorhynchus mykiss) Following Administration of Medicated Feed

Yazarlar: İdris TÜREL | Gürdal DAĞOĞLU | Orhan YILMAZ

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 2003 Vol.27 Issue 1, pp.223-227

Belge Tipi: Makale

Yayın Tarihi: 12/2002

Belge Dili: Türkçe

Document ID (Org No.): 2000770341

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Rainbow trout

oxytetracycline

pharmacokinetic

oral bioavailability

Sayı

Yazarlar:

İdris TÜREL | Gürdal DAĞOĞLU | Orhan YILMAZ

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2003 Vol.27 Issue 1, pp.223-227

Belge Tipi:

Makale

Yayın Tarihi:

12/2002

Belge Dili:

Türkçe

Document ID (Org No.):

2000770341

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128