5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents

Siva Krishna Vagolu; Sriram Dharmarajan; Keriman Ozadalı Sarı

Makale detayları

5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents

Yazarlar:

Siva Krishna Vagolu | Sriram Dharmarajan | Keriman Ozadalı Sarı

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 1, pp.30-37

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346749

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds 2a and 2c were determined by the single-crystal Xray diffraction study. Among the target compounds, 2-4-ethoxyphenyl-5-methyl-3-phenylaminothiazolidin-4-one 2g was promising with a minimum inhibitory concentration of 12.5 μgmL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity.

 This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds 2a and 2c were determined by the single-crystal Xray diffraction study. Among the target compounds, 2-4-ethoxyphenyl-5-methyl-3-phenylaminothiazolidin-4-one 2g was promising with a minimum inhibitory concentration of 12.5 μgmL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity.

 This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds 2a and 2c were determined by the single-crystal Xray diffraction study. Among the target compounds, 2-4-ethoxyphenyl-5-methyl-3-phenylaminothiazolidin-4-one 2g was promising with a minimum inhibitory concentration of 12.5 μgmL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity.

 This paper reports the synthesis, characterization and evaluation of some 5-methyl-4-thiazolidinone derivatives for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv strain by microplate alamar blue assay. Also the crystal structures of the compounds 2a and 2c were determined by the single-crystal Xray diffraction study. Among the target compounds, 2-4-ethoxyphenyl-5-methyl-3-phenylaminothiazolidin-4-one 2g was promising with a minimum inhibitory concentration of 12.5 μgmL against M. tuberculosis. Based on the preliminary results, 2g was considered as a lead compound for further optimization of antimycobacterial activity.

Makale detayları

5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents

Yazarlar:

Siva Krishna Vagolu | Sriram Dharmarajan | Keriman Ozadalı Sarı

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 1, pp.30-37

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346749

pISSN:

2630-6344

Antimycobacterial

tuberculosis

4-thiazolidinone

single-crystal X-ray diffraction

Sayı

Makale detayları

5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents

Yazarlar: Siva Krishna Vagolu | Sriram Dharmarajan | Keriman Ozadalı Sarı

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Chemistry

Dergi: Journal of Research in Pharmacy Vol.24 Issue 1, pp.30-37

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346749

pISSN: 2630-6344

Antimycobacterial

tuberculosis

4-thiazolidinone

single-crystal X-ray diffraction

Sayı

Yazarlar:

Siva Krishna Vagolu | Sriram Dharmarajan | Keriman Ozadalı Sarı

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Chemistry

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 1, pp.30-37

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346749

pISSN:

2630-6344