Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience

Ezgi Paslı Uysalol; Cengiz Bayram; Gül Özdemir; Sibel Akpınar Tekgündüz; Müzeyyen Gönül Aydoğan; Ali Ayçiçek

Makale detayları

Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience

Yazarlar:

Ezgi Paslı Uysalol | Cengiz Bayram | Gül Özdemir | Sibel Akpınar Tekgündüz | Müzeyyen Gönül Aydoğan | Ali Ayçiçek

Yayıncı:

Istanbul University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Çocuk Dergisi Vol.23 Issue 3, pp.265-269

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303679

pISSN:

1308-8491

Anahtar kelimeler:

Özet:

 Objective: Acute lymphoblastic leukemia ALL is one of the most common malignant diseases in children. This study aimed to determine the clinical and prognostic characteristics of adolescent patients with ALL aged 1518 years who were followed up in our center. Materials and Methods: The clinical and laboratory characteristics, treatment responses, and survival and relapse rates of adolescent patients with ALL were retrospectively analyzed Results: The majority of patients were male. The median age of patients was 16 range 1517.9 years. About 36 and 74 of patients were diagnosed with T- and B-cell ALLs, respectively. Then, 32 of patients were stratified in the high-risk group. BCRABL t 9;22 positivity was detected in one patient. Recurrence was observed in 6 of 31 patients after completing the treatment. The estimated survival rate in the high-risk group at 32 months was 58. Conclusion: Ihe prognosis and outcomes of ALL in adolescent and young adult patients are poor compared to younger age groups. Future clinical trials and advance in chemotherapeutic protocols in this age group will help increase the treatment success rates.

 Objective: Acute lymphoblastic leukemia ALL is one of the most common malignant diseases in children. This study aimed to determine the clinical and prognostic characteristics of adolescent patients with ALL aged 1518 years who were followed up in our center. Materials and Methods: The clinical and laboratory characteristics, treatment responses, and survival and relapse rates of adolescent patients with ALL were retrospectively analyzed Results: The majority of patients were male. The median age of patients was 16 range 1517.9 years. About 36 and 74 of patients were diagnosed with T- and B-cell ALLs, respectively. Then, 32 of patients were stratified in the high-risk group. BCRABL t 9;22 positivity was detected in one patient. Recurrence was observed in 6 of 31 patients after completing the treatment. The estimated survival rate in the high-risk group at 32 months was 58. Conclusion: Ihe prognosis and outcomes of ALL in adolescent and young adult patients are poor compared to younger age groups. Future clinical trials and advance in chemotherapeutic protocols in this age group will help increase the treatment success rates.

 Objective: Acute lymphoblastic leukemia ALL is one of the most common malignant diseases in children. This study aimed to determine the clinical and prognostic characteristics of adolescent patients with ALL aged 1518 years who were followed up in our center. Materials and Methods: The clinical and laboratory characteristics, treatment responses, and survival and relapse rates of adolescent patients with ALL were retrospectively analyzed Results: The majority of patients were male. The median age of patients was 16 range 1517.9 years. About 36 and 74 of patients were diagnosed with T- and B-cell ALLs, respectively. Then, 32 of patients were stratified in the high-risk group. BCRABL t 9;22 positivity was detected in one patient. Recurrence was observed in 6 of 31 patients after completing the treatment. The estimated survival rate in the high-risk group at 32 months was 58. Conclusion: Ihe prognosis and outcomes of ALL in adolescent and young adult patients are poor compared to younger age groups. Future clinical trials and advance in chemotherapeutic protocols in this age group will help increase the treatment success rates.

 Amaç: Akut lenfoblastik lösemi ALL çocukluk çağında en sık rastlanan habis hastalıklardan biridir. Çalışmamızda merkezimizde ALL tanısı ile takip ve tedavi edilen, 15-18 yaş arası adölesan hastaların klinik ve prognostik özelliklerini belirlemeyi amaçladık. Gereç ve Yöntem: ALLli adolesan hastaların klinik ve laboratuvar özellikleri, tedavi yanıtları, sağkalım ve nüks oranları retrospektif olarak analiz edildi. Bulgular: Hastaların çoğunluğunu erkekler oluşturmaktaydı.Median yaş değeri 16 15-17,9 yıl idi. Hastaların 32si yüksek risk grubundaydı ve 26sı T hücreli ALL 74ü B hücreli ALL immunfenotipi göstermekteydi. BCRLABL t 9;22 pozitifliği bir hastada saptandı. Altı hastamızda tedavi bitimi sonrası nüks görüldü. Yüksek risk grubunda otuz ikinci ayda tahmini sağ kalım oranı 58 idi. Sonuç: Ergen ve genç yetişkin hastaların prognozu ve sonuçları diğer küçük yaş gruplarından farklı olarak daha kötüdür. Çocukluk çağında kullanılan protokollerin, bu yaş grubuna özel klinik araştırmalarla geliştirilmesi tedavide başarı oranlarının artmasına katkı sağlayacaktır.

Makale detayları

Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience

Yazarlar:

Ezgi Paslı Uysalol | Cengiz Bayram | Gül Özdemir | Sibel Akpınar Tekgündüz | Müzeyyen Gönül Aydoğan | Ali Ayçiçek

Yayıncı:

Istanbul University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Çocuk Dergisi Vol.23 Issue 3, pp.265-269

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303679

pISSN:

1308-8491

adolescent

leukemia

survivaladolesan

çocuk

sağkalım

Sayı

Makale detayları

Adolescent Acute Lymphoblastic Leukemia: A Retrospective Single-Center Experience

Yazarlar: Ezgi Paslı Uysalol | Cengiz Bayram | Gül Özdemir | Sibel Akpınar Tekgündüz | Müzeyyen Gönül Aydoğan | Ali Ayçiçek

Yayıncı: Istanbul University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: Çocuk Dergisi Vol.23 Issue 3, pp.265-269

Belge Tipi: Makale

Yayın Tarihi: 10/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001303679

pISSN: 1308-8491

adolescent

leukemia

survivaladolesan

çocuk

sağkalım

Sayı

Yazarlar:

Ezgi Paslı Uysalol | Cengiz Bayram | Gül Özdemir | Sibel Akpınar Tekgündüz | Müzeyyen Gönül Aydoğan | Ali Ayçiçek

Yayıncı:

Istanbul University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Çocuk Dergisi Vol.23 Issue 3, pp.265-269

Belge Tipi:

Makale

Yayın Tarihi:

10/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001303679

pISSN:

1308-8491