Anticancer Activities of Zinc Oxide Nanoparticles (ZnONPs) Synthesized from Mentha longifolia L. Leaf Extract

Polat İpek; Mehmet Fırat Baran; Abdulkerim Hatipoğlu; Ayşe Baran

Makale detayları

Anticancer Activities of Zinc Oxide Nanoparticles (ZnONPs) Synthesized from Mentha longifolia L. Leaf Extract

Yazarlar:

Polat İpek | Mehmet Fırat Baran | Abdulkerim Hatipoğlu | Ayşe Baran

Yayıncı:

Igdir University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.14 Issue 1, pp.107-114

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001311752

pISSN:

2536-4618

Anahtar kelimeler:

Özet:

 Recently, there has been a remarkable increase in cancer and cancer-related deaths. In this study, the impacts of zinc oxide nanoparticles ZnONPs produced from the aqueous leaf extract of Mentha longifolia L. ML on ovary adenocarcinoma OVCAR-3, colorectal carcinoma HCT-116, and healthy retinal pigment epithelial cell RPE-1 lines were investigated. The MTT 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide test was performed to discover its antiproliferative properties. As a result of the application of ML-ZnONPs on RPE-1, OVCAR-3, and HCT-116 cell lines at doses µgmL of 250, 500, and 1000 for 24 hours, the viability rates  in the cell lines were 18.73-30.56, 21.98-28.76, and 27.27-40.93, respectively. In the 48-hour application, the viability rates  of the same cells were between 29.51-46.83, 32.49-40.81, and 46.82-44.37, respectively. The MTT test revealed that ML-ZnONPs strongly suppressed the growth of RPE-1, OVCAR-3, and HCT-116 cell lines. The test showed that the effect of dose increase and time on the viability of both cancer cell lines was negative.

 Recently, there has been a remarkable increase in cancer and cancer-related deaths. In this study, the impacts of zinc oxide nanoparticles ZnONPs produced from the aqueous leaf extract of Mentha longifolia L. ML on ovary adenocarcinoma OVCAR-3, colorectal carcinoma HCT-116, and healthy retinal pigment epithelial cell RPE-1 lines were investigated. The MTT 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide test was performed to discover its antiproliferative properties. As a result of the application of ML-ZnONPs on RPE-1, OVCAR-3, and HCT-116 cell lines at doses µgmL of 250, 500, and 1000 for 24 hours, the viability rates  in the cell lines were 18.73-30.56, 21.98-28.76, and 27.27-40.93, respectively. In the 48-hour application, the viability rates  of the same cells were between 29.51-46.83, 32.49-40.81, and 46.82-44.37, respectively. The MTT test revealed that ML-ZnONPs strongly suppressed the growth of RPE-1, OVCAR-3, and HCT-116 cell lines. The test showed that the effect of dose increase and time on the viability of both cancer cell lines was negative.

 Recently, there has been a remarkable increase in cancer and cancer-related deaths. In this study, the impacts of zinc oxide nanoparticles ZnONPs produced from the aqueous leaf extract of Mentha longifolia L. ML on ovary adenocarcinoma OVCAR-3, colorectal carcinoma HCT-116, and healthy retinal pigment epithelial cell RPE-1 lines were investigated. The MTT 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide test was performed to discover its antiproliferative properties. As a result of the application of ML-ZnONPs on RPE-1, OVCAR-3, and HCT-116 cell lines at doses µgmL of 250, 500, and 1000 for 24 hours, the viability rates  in the cell lines were 18.73-30.56, 21.98-28.76, and 27.27-40.93, respectively. In the 48-hour application, the viability rates  of the same cells were between 29.51-46.83, 32.49-40.81, and 46.82-44.37, respectively. The MTT test revealed that ML-ZnONPs strongly suppressed the growth of RPE-1, OVCAR-3, and HCT-116 cell lines. The test showed that the effect of dose increase and time on the viability of both cancer cell lines was negative.

 Recently, there has been a remarkable increase in cancer and cancer-related deaths. In this study, the impacts of zinc oxide nanoparticles ZnONPs produced from the aqueous leaf extract of Mentha longifolia L. ML on ovary adenocarcinoma OVCAR-3, colorectal carcinoma HCT-116, and healthy retinal pigment epithelial cell RPE-1 lines were investigated. The MTT 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide test was performed to discover its antiproliferative properties. As a result of the application of ML-ZnONPs on RPE-1, OVCAR-3, and HCT-116 cell lines at doses µgmL of 250, 500, and 1000 for 24 hours, the viability rates  in the cell lines were 18.73-30.56, 21.98-28.76, and 27.27-40.93, respectively. In the 48-hour application, the viability rates  of the same cells were between 29.51-46.83, 32.49-40.81, and 46.82-44.37, respectively. The MTT test revealed that ML-ZnONPs strongly suppressed the growth of RPE-1, OVCAR-3, and HCT-116 cell lines. The test showed that the effect of dose increase and time on the viability of both cancer cell lines was negative.

Makale detayları

Anticancer Activities of Zinc Oxide Nanoparticles (ZnONPs) Synthesized from Mentha longifolia L. Leaf Extract

Yazarlar:

Polat İpek | Mehmet Fırat Baran | Abdulkerim Hatipoğlu | Ayşe Baran

Yayıncı:

Igdir University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.14 Issue 1, pp.107-114

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001311752

pISSN:

2536-4618

Cytotoxic potential

Mentha longifolia L.

Zinc oxide nanoparticles

MTT

HCT-116

OVCAR-3

Sayı

Makale detayları

Anticancer Activities of Zinc Oxide Nanoparticles (ZnONPs) Synthesized from Mentha longifolia L. Leaf Extract

Yazarlar: Polat İpek | Mehmet Fırat Baran | Abdulkerim Hatipoğlu | Ayşe Baran

Yayıncı: Igdir University

Ana Başlıklar: Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi: Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.14 Issue 1, pp.107-114

Belge Tipi: Makale

Yayın Tarihi: 1/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001311752

pISSN: 2536-4618

Cytotoxic potential

Mentha longifolia L.

Zinc oxide nanoparticles

MTT

HCT-116

OVCAR-3

Sayı

Yazarlar:

Polat İpek | Mehmet Fırat Baran | Abdulkerim Hatipoğlu | Ayşe Baran

Yayıncı:

Igdir University

Ana Başlıklar:

Biyokimya ve Hücre Biyolojisi (Diğer)

Dergi:

Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi Vol.14 Issue 1, pp.107-114

Belge Tipi:

Makale

Yayın Tarihi:

1/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001311752

pISSN:

2536-4618