INVESTIGATION OF THE RELATION BETWEEN DOPAMINE DEPLETION AND THE SLOWING OF ALPHA RHYTHM IN ELECTROENCEPHALOGRAM OF THALAMUS

Yüksel ÇAKİR

Makale detayları

INVESTIGATION OF THE RELATION BETWEEN DOPAMINE DEPLETION AND THE SLOWING OF ALPHA RHYTHM IN ELECTROENCEPHALOGRAM OF THALAMUS

Yazarlar:

Yüksel ÇAKİR

Yayıncı:

İstanbul Technical University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

The Journal of Cognitive Systems 2019 Vol.4 Issue 1, pp.22-27

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000664851

Sıklık:

İki Yıllık

pISSN:

2548-0650

Özet:

 

A hybrid computational model of thalamo-cortical
circuitry and basal ganglia is used to investigate the relation between the
electroencephalogram (EEG) changes within the alpha frequency bands in thalamic
region depending on the decrease in the dopamine level in striatum.  Since it is known that in the diseases such
as Alzheimer and Parkinson, the level of dopamine decreases, the related
changes in thalamic region is investigated considering the dopamine depletion. The
diseases affects the dopamine decrease in different ways, such that in
Parkinsonian disease (PD), the total amount of dopamine affecting striatal
neurons decreases whereas in Alzheimer disease (AD), the dopamine level
decreases mostly in D2 dopamine receptor neurons. Therefore, these differences
are analyzed to investigate the slowing of alpha rhythm on EEG of thalamus by
using the modified mass model of thalamic region. It is observed that the
decrease in the amount of dopamine causes shift of the power in alpha bands to
lower frequencies. When the dopamine level is decreased in D1 and D2 type MSN
neurons, the slowing of alpha rhythm in EEG of thalamus is prominent. .

Makale detayları

INVESTIGATION OF THE RELATION BETWEEN DOPAMINE DEPLETION AND THE SLOWING OF ALPHA RHYTHM IN ELECTROENCEPHALOGRAM OF THALAMUS

Yazarlar: Yüksel ÇAKİR

Yayıncı: İstanbul Technical University

Ana Başlıklar: Uygulamalı fizik

Dergi: The Journal of Cognitive Systems 2019 Vol.4 Issue 1, pp.22-27

Belge Tipi: Makale

Yayın Tarihi: 6/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000664851

Sıklık: İki Yıllık

pISSN: 2548-0650

Sayı

Yazarlar:

Yüksel ÇAKİR

Yayıncı:

İstanbul Technical University

Ana Başlıklar:

Uygulamalı fizik

Dergi:

The Journal of Cognitive Systems 2019 Vol.4 Issue 1, pp.22-27

Belge Tipi:

Makale

Yayın Tarihi:

6/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000664851

Sıklık:

İki Yıllık

pISSN:

2548-0650