Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients

N.A.

Makale detayları

Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Sciences

Dergi:

Marmara Medical Journal Vol.36 Issue 2, pp.175-181

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289749

pISSN:

1019-1941

Anahtar kelimeler:

Özet:

 Objective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19. Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were included in the study. Results: The study included 226 patients. According to the World Health Organization staging, 7533.2 patients, according to the staging of Siddiqi et al., 67 29.7 patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer was found to be 82.25 95CI 74.8-89.71. When the cut-off value for D-dimer was accepted as 3.25mgL, specificity was 94.15, correctly classified rate 88.5, positive likelihood ratio as LR:5.69, negative LR:0.71. Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality in Turkish patients with COVID-19. D-dimer levels of 3.25 mgL and above, strongly determine the risk of increased mortality in the Turkish Caucasian ethnic group.

 Objective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19. Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were included in the study. Results: The study included 226 patients. According to the World Health Organization staging, 7533.2 patients, according to the staging of Siddiqi et al., 67 29.7 patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer was found to be 82.25 95CI 74.8-89.71. When the cut-off value for D-dimer was accepted as 3.25mgL, specificity was 94.15, correctly classified rate 88.5, positive likelihood ratio as LR:5.69, negative LR:0.71. Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality in Turkish patients with COVID-19. D-dimer levels of 3.25 mgL and above, strongly determine the risk of increased mortality in the Turkish Caucasian ethnic group.

 Objective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19. Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were included in the study. Results: The study included 226 patients. According to the World Health Organization staging, 7533.2 patients, according to the staging of Siddiqi et al., 67 29.7 patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer was found to be 82.25 95CI 74.8-89.71. When the cut-off value for D-dimer was accepted as 3.25mgL, specificity was 94.15, correctly classified rate 88.5, positive likelihood ratio as LR:5.69, negative LR:0.71. Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality in Turkish patients with COVID-19. D-dimer levels of 3.25 mgL and above, strongly determine the risk of increased mortality in the Turkish Caucasian ethnic group.

 Objective: Coagulopathy is thought to play an important role in the development of severe COVID-19. High D-dimer levels have been reported in Chinese cohort studies. However, ethnicity has significant implications for thrombotic risk. Our aim in this study is to determine the effect of D-dimer measurements on disease prognosis and mortality in Turkish patients with COVID-19. Patients and Methods: The study was designed retrospectively. Patients over the age of 18 who were admitted to our hospital were included in the study. Results: The study included 226 patients. According to the World Health Organization staging, 7533.2 patients, according to the staging of Siddiqi et al., 67 29.7 patients progressed. In the ROC analysis performed to predict mortality, AUC value for D-dimer was found to be 82.25 95CI 74.8-89.71. When the cut-off value for D-dimer was accepted as 3.25mgL, specificity was 94.15, correctly classified rate 88.5, positive likelihood ratio as LR:5.69, negative LR:0.71. Conclusion: As a result, similar to the Chinese cohorts, elevated D-dimer measurements increase disease progression and mortality in Turkish patients with COVID-19. D-dimer levels of 3.25 mgL and above, strongly determine the risk of increased mortality in the Turkish Caucasian ethnic group.

Makale detayları

Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Sciences

Dergi:

Marmara Medical Journal Vol.36 Issue 2, pp.175-181

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289749

pISSN:

1019-1941

COVID-19

D-dimer

Mortality

Ethnicity

Sayı

Makale detayları

Increased D-dimer is associated with disease progression and increased mortality in Turkish COVID-19 patients

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Clinical Sciences

Dergi: Marmara Medical Journal Vol.36 Issue 2, pp.175-181

Belge Tipi: Makale

Yayın Tarihi: 5/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001289749

pISSN: 1019-1941

COVID-19

D-dimer

Mortality

Ethnicity

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Clinical Sciences

Dergi:

Marmara Medical Journal Vol.36 Issue 2, pp.175-181

Belge Tipi:

Makale

Yayın Tarihi:

5/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001289749

pISSN:

1019-1941