The utility of biomarkers to predict steroid response in idiopathic nephrotic syndrome

Neslihan Çiçek; İbrahim Gökçe; Serçin Güven; Harika Alpay

Makale detayları

The utility of biomarkers to predict steroid response in idiopathic nephrotic syndrome

Yazarlar:

Neslihan Çiçek | İbrahim Gökçe | Serçin Güven | Harika Alpay

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.37 Issue 3, pp.295-299

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330825

pISSN:

1019-1941

Anahtar kelimeler:

Özet:

 Objective: The most common form of nephrotic syndrome NS is minimal change disease MCD in children and focal segmental glomerulosclerosis FSGS following it. As, it is important to predict corticosteroid CS response at the beginning of the disease, we aimed to evaluate the efficacy of some biomarkers in terms of predicting steroid response in patients with NS. Patients and Methods: Twenty patients who met the inclusion criteria for the study were divided into 3 groups and 6 healthy control participants were included in the analysis as the 4th group. Group-1 included 10 patients at the first episode of idiopathic NS INS, group-2 included the same 10 patients in remission, group-3 included 10 patients with steroid resistant NS SRNS diagnosed as FSGS by renal biopsy, and group-4 included six healthy children as controls. Urinary and serum cluster of differentiation CD CD80, IL-17, IL-23, IL-10, TGF-β, CD86, CD28, CTLA-4 levels were measured for all groups. Results: Urinary CD80 level in INS-relapse group was significantly higher than the levels of the INS-remission, FSGS and control groups p0.001. Urinary CD28 and uIL-10 were significantly increased in INS-remission group than INS-relapse p0.05, p0.001. Serum IL-17 was significantly higher in INS-relapse group than in INS-remission group p0.01. There was no difference in IL- 23,TGF-β,CD86 parameters between groups. Conclusion: In our study, urinary CD80 levels were significantly higher in the relapse group compared to the other groups. When supported by more.

 Objective: The most common form of nephrotic syndrome NS is minimal change disease MCD in children and focal segmental glomerulosclerosis FSGS following it. As, it is important to predict corticosteroid CS response at the beginning of the disease, we aimed to evaluate the efficacy of some biomarkers in terms of predicting steroid response in patients with NS. Patients and Methods: Twenty patients who met the inclusion criteria for the study were divided into 3 groups and 6 healthy control participants were included in the analysis as the 4th group. Group-1 included 10 patients at the first episode of idiopathic NS INS, group-2 included the same 10 patients in remission, group-3 included 10 patients with steroid resistant NS SRNS diagnosed as FSGS by renal biopsy, and group-4 included six healthy children as controls. Urinary and serum cluster of differentiation CD CD80, IL-17, IL-23, IL-10, TGF-β, CD86, CD28, CTLA-4 levels were measured for all groups. Results: Urinary CD80 level in INS-relapse group was significantly higher than the levels of the INS-remission, FSGS and control groups p0.001. Urinary CD28 and uIL-10 were significantly increased in INS-remission group than INS-relapse p0.05, p0.001. Serum IL-17 was significantly higher in INS-relapse group than in INS-remission group p0.01. There was no difference in IL- 23,TGF-β,CD86 parameters between groups. Conclusion: In our study, urinary CD80 levels were significantly higher in the relapse group compared to the other groups. When supported by more.

 Objective: The most common form of nephrotic syndrome NS is minimal change disease MCD in children and focal segmental glomerulosclerosis FSGS following it. As, it is important to predict corticosteroid CS response at the beginning of the disease, we aimed to evaluate the efficacy of some biomarkers in terms of predicting steroid response in patients with NS. Patients and Methods: Twenty patients who met the inclusion criteria for the study were divided into 3 groups and 6 healthy control participants were included in the analysis as the 4th group. Group-1 included 10 patients at the first episode of idiopathic NS INS, group-2 included the same 10 patients in remission, group-3 included 10 patients with steroid resistant NS SRNS diagnosed as FSGS by renal biopsy, and group-4 included six healthy children as controls. Urinary and serum cluster of differentiation CD CD80, IL-17, IL-23, IL-10, TGF-β, CD86, CD28, CTLA-4 levels were measured for all groups. Results: Urinary CD80 level in INS-relapse group was significantly higher than the levels of the INS-remission, FSGS and control groups p0.001. Urinary CD28 and uIL-10 were significantly increased in INS-remission group than INS-relapse p0.05, p0.001. Serum IL-17 was significantly higher in INS-relapse group than in INS-remission group p0.01. There was no difference in IL- 23,TGF-β,CD86 parameters between groups. Conclusion: In our study, urinary CD80 levels were significantly higher in the relapse group compared to the other groups. When supported by more.

 Objective: The most common form of nephrotic syndrome NS is minimal change disease MCD in children and focal segmental glomerulosclerosis FSGS following it. As, it is important to predict corticosteroid CS response at the beginning of the disease, we aimed to evaluate the efficacy of some biomarkers in terms of predicting steroid response in patients with NS. Patients and Methods: Twenty patients who met the inclusion criteria for the study were divided into 3 groups and 6 healthy control participants were included in the analysis as the 4th group. Group-1 included 10 patients at the first episode of idiopathic NS INS, group-2 included the same 10 patients in remission, group-3 included 10 patients with steroid resistant NS SRNS diagnosed as FSGS by renal biopsy, and group-4 included six healthy children as controls. Urinary and serum cluster of differentiation CD CD80, IL-17, IL-23, IL-10, TGF-β, CD86, CD28, CTLA-4 levels were measured for all groups. Results: Urinary CD80 level in INS-relapse group was significantly higher than the levels of the INS-remission, FSGS and control groups p0.001. Urinary CD28 and uIL-10 were significantly increased in INS-remission group than INS-relapse p0.05, p0.001. Serum IL-17 was significantly higher in INS-relapse group than in INS-remission group p0.01. There was no difference in IL- 23,TGF-β,CD86 parameters between groups. Conclusion: In our study, urinary CD80 levels were significantly higher in the relapse group compared to the other groups. When supported by more.

Makale detayları

The utility of biomarkers to predict steroid response in idiopathic nephrotic syndrome

Yazarlar:

Neslihan Çiçek | İbrahim Gökçe | Serçin Güven | Harika Alpay

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.37 Issue 3, pp.295-299

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330825

pISSN:

1019-1941

Biomarkers

CD80

Nephrotic syndrome

Steroid response

Sayı

Makale detayları

The utility of biomarkers to predict steroid response in idiopathic nephrotic syndrome

Yazarlar: Neslihan Çiçek | İbrahim Gökçe | Serçin Güven | Harika Alpay

Yayıncı: Marmara University

Ana Başlıklar: Surgery (Other)

Dergi: Marmara Medical Journal Vol.37 Issue 3, pp.295-299

Belge Tipi: Makale

Yayın Tarihi: 10/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001330825

pISSN: 1019-1941

Biomarkers

CD80

Nephrotic syndrome

Steroid response

Sayı

Yazarlar:

Neslihan Çiçek | İbrahim Gökçe | Serçin Güven | Harika Alpay

Yayıncı:

Marmara University

Ana Başlıklar:

Surgery (Other)

Dergi:

Marmara Medical Journal Vol.37 Issue 3, pp.295-299

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001330825

pISSN:

1019-1941