DETECTING DRUG-DRUG INTERACTIONS INDUCED BY ANTACIDS ENCOUNTERED IN A COMMUNITY PHARMACY: AN OBSERVATIONAL STUDY

Miray Arslan

Makale detayları

DETECTING DRUG-DRUG INTERACTIONS INDUCED BY ANTACIDS ENCOUNTERED IN A COMMUNITY PHARMACY: AN OBSERVATIONAL STUDY

Yazarlar:

Miray Arslan

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılık İşletmeciliği

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.48 Issue 2, pp.479-485

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001311414

pISSN:

1015-3918

Anahtar kelimeler:

Özet:

 Objective: This study aimed to reveal drug-drug interactions DDIs due to antacids through programs used to detect DDIs. Material and Method: Within the scope of this study, 207 prescriptions containing at least one antacid and a drug from a different pharmacological group were evaluated in terms of DDIs. Evaluations were made on the prescriptions received in a community pharmacy serving in Van, Türkiye. Three different DDI checking programs were used for this evaluation. Result and Discussion: Antacid-induced DDIs were detected in 64 of the prescriptions. Interactions occurred between 52 active ingredient pairs, and it was revealed that DDIs were most common between calcium carbonate and famotidine. This interaction is minor and has been detected by only one database. Another common interaction was found between the calcium carbonate and cholecalciferol Vitamin D pair, and this interaction was reported as Level 2 and should be closely monitored in two different databases. As a result, DDIs induced by antiacids generally were found to be at moderate levels. However, it is seen that three DDI checking programs used in the study provide different results in detecting DDIs.

 Objective: This study aimed to reveal drug-drug interactions DDIs due to antacids through programs used to detect DDIs. Material and Method: Within the scope of this study, 207 prescriptions containing at least one antacid and a drug from a different pharmacological group were evaluated in terms of DDIs. Evaluations were made on the prescriptions received in a community pharmacy serving in Van, Türkiye. Three different DDI checking programs were used for this evaluation. Result and Discussion: Antacid-induced DDIs were detected in 64 of the prescriptions. Interactions occurred between 52 active ingredient pairs, and it was revealed that DDIs were most common between calcium carbonate and famotidine. This interaction is minor and has been detected by only one database. Another common interaction was found between the calcium carbonate and cholecalciferol Vitamin D pair, and this interaction was reported as Level 2 and should be closely monitored in two different databases. As a result, DDIs induced by antiacids generally were found to be at moderate levels. However, it is seen that three DDI checking programs used in the study provide different results in detecting DDIs.

 Objective: This study aimed to reveal drug-drug interactions DDIs due to antacids through programs used to detect DDIs. Material and Method: Within the scope of this study, 207 prescriptions containing at least one antacid and a drug from a different pharmacological group were evaluated in terms of DDIs. Evaluations were made on the prescriptions received in a community pharmacy serving in Van, Türkiye. Three different DDI checking programs were used for this evaluation. Result and Discussion: Antacid-induced DDIs were detected in 64 of the prescriptions. Interactions occurred between 52 active ingredient pairs, and it was revealed that DDIs were most common between calcium carbonate and famotidine. This interaction is minor and has been detected by only one database. Another common interaction was found between the calcium carbonate and cholecalciferol Vitamin D pair, and this interaction was reported as Level 2 and should be closely monitored in two different databases. As a result, DDIs induced by antiacids generally were found to be at moderate levels. However, it is seen that three DDI checking programs used in the study provide different results in detecting DDIs.

 Amaç: Bu çalışma, ilaç-ilaç etkileşimlerini DDIs tespit etmek için kullanılan programlar aracılığıyla antiasitler nedeniyle oluşan DDIleri tespit etmeyi amaçlamaktadır. Gereç ve Yöntem: Bu çalışma kapsamında en az bir antiasit ve farklı farmakolojik gruptan bir ilaç içeren 207 reçete DDI açısından ele alınmıştır. Bu doğrultuda, Vanda hizmet veren bir toplum eczanesinde karşılanan reçeteler değerlendirilmiştir. Bu değerlendirmeler için üç farklı DDI kontrol programı kullanılmıştır. Sonuç ve Tartışma: Reçetelerin 64ünde antiasit kaynaklı DDI tespit edilmiştir. 52 aktif madde çifti arasında etkileşim meydana gelmiş olup, DDIların en yaygın olarak kalsiyum karbonat ve famotidin arasında olduğu ortaya konulmuştur. Bu etkileşimin minor düzeyde olup, yalnızca bir veritabanı tarafından tespit edilmiştir. Diğer bir sık karşılaşılan etkileşim ise kalsiyum karbonat ve kolekalsiferol Vitamin D çifti arasında bulunmuştur. Bu etkileşim Düzey 2 ve yakından takip edilmesi gerekir olacak şekilde iki farklı program tarafından tespit edilmiştir. Sonuç olarak antiasitlerin neden olduğu DDIların genel olarak orta düzeyde ciddiyete sahip olduğu bulunmuştur. Ancak çalışmada kullanılan üç DDI kontrol programının DDIların tespitinde farklı sonuçlar verdiği görülmüştür.

Makale detayları

DETECTING DRUG-DRUG INTERACTIONS INDUCED BY ANTACIDS ENCOUNTERED IN A COMMUNITY PHARMACY: AN OBSERVATIONAL STUDY

Yazarlar:

Miray Arslan

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılık İşletmeciliği

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.48 Issue 2, pp.479-485

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001311414

pISSN:

1015-3918

Antacids

community pharmacy

drug-drug interactions

observational studyAntasitler

gözlemsel çalışma

ilaç-ilaç etkileşimleri

toplum eczanesi

Sayı

Makale detayları

Yazarlar: Miray Arslan

Yayıncı: Ankara University

Ana Başlıklar: Eczacılık İşletmeciliği

Dergi: Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.48 Issue 2, pp.479-485

Belge Tipi: Makale

Yayın Tarihi: 5/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001311414

pISSN: 1015-3918

Sayı

Yazarlar:

Miray Arslan

Yayıncı:

Ankara University

Ana Başlıklar:

Eczacılık İşletmeciliği

Dergi:

Ankara Üniversitesi Eczacılık Fakültesi Dergisi Vol.48 Issue 2, pp.479-485

Belge Tipi:

Makale

Yayın Tarihi:

5/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001311414

pISSN:

1015-3918