The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients

Gonca SOYUDURU; Esra Özsoy ADIŞEN; İlkay ÖZER; Ahmet Burhan AKSAKAL

Makale detayları

The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients

Yazarlar:

Gonca SOYUDURU | Esra Özsoy ADIŞEN | İlkay ÖZER | Ahmet Burhan AKSAKAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 1, pp.238-244

Belge Tipi:

Makale

Yayın Tarihi:

1/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750342

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Recent data draw attention to the effect of body composition, insulin resistance, and adipocytokines to acne vulgaris (AV) development. The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels. Materials and methods: In 29 AV patients and 29 healthy volunteers, body mass index (BMI) and body fat mass (BFM), lipid, adiponectin, leptin, resistin, retinol binding protein-4 (RBP4), and insulin levels were measured and insulin resistance was assessed by HOMA-IR index in serum samples taken twice from patients before and after isotretinoin treatment.Results: In AV patients, pretreatment HOMA-IR and adipocytokine levels were not found to correlate with disease severity. With five months of isotretinoin treatment, higher HOMA-IR values  were found (P = 0.028). Isotretinoin therapy maintained lower mean resistin levels (P = 0.016), higher mean RBP4 levels (P = 0.040), but not affected the mean adiponectin and leptin levels (P = 0.113, P = 0.125, respectively).  Conclusions: All data suggests that five months of isotretinoin therapy in AV patients causes insulin resistance and the increase in in-sulin resistance is not dependent on age, BMI, BFM, and lipid levels of these patients.

Makale detayları

The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients

Yazarlar: Gonca SOYUDURU | Esra Özsoy ADIŞEN | İlkay ÖZER | Ahmet Burhan AKSAKAL

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 1, pp.238-244

Belge Tipi: Makale

Yayın Tarihi: 1/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000750342

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Gonca SOYUDURU | Esra Özsoy ADIŞEN | İlkay ÖZER | Ahmet Burhan AKSAKAL

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 1, pp.238-244

Belge Tipi:

Makale

Yayın Tarihi:

1/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750342

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144