Effect of MCP-1 and CCR2 Serum Levels on COVID-19 Severity

Selen Zeliha Mart Kömürcü; Şeydanur Doğan; Ebru Kaya; Sevim Yavaş; Serkan Doğan; Utku Murat Kalafat; Hayriye Şentürk Çiftçi; Selçuk Daşdemir

Makale detayları

Effect of MCP-1 and CCR2 Serum Levels on COVID-19 Severity

Yazarlar:

Selen Zeliha Mart Kömürcü | Şeydanur Doğan | Ebru Kaya | Sevim Yavaş | Serkan Doğan | Utku Murat Kalafat | Hayriye Şentürk Çiftçi | Selçuk Daşdemir

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Experimed Vol.13 Issue 3, pp.276-280

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310805

pISSN:

2667-5846

Anahtar kelimeler:

Özet:

 Objective: Approximately 80 of people with coronavirus disease 2019 COVID-19 are asymptomatic, and only a small proportion of cases show serious consequences leading to hospitalization. The interplay between chemokines and their receptors can affect the severity of several infectious diseases, such as severe acute respiratory syndrome and Middle East Respiratory Syndrome. The interplay of monocyte chemoattractant protein-1 MCP-1 with its receptor C-C motif chemokine receptor 2 CCR2 may affect the pathogenesis of COVID-19 by functioning in the dispatch of lymphocytes and monocytesmacrophages to the infection site. Materials and Methods: The serum MCP-1 and CCR2 concentrations were measured using the enzyme-linked immunosorbent assay ELISA in 49 asymptomatic, 50 severe, and 57 critical COVID-19 cases. Results: Serum MCP-1 levels were considerably higher in critical cases than in cases in the other two groups, suggesting an increased risk for disease severity p  0.008; p  0.01, respectively. Serum CCR2 levels were significantly higher in asymptomatic cases than in critical cases suggesting a protective role against disease severity p  0.001. Conclusion: MCP-1 and CCR2 may be candidate biomarkers for the prediction of disease severity. Therefore, by measuring serum levels of MCP-1 and CCR2 early, the disease course can be predicted , and necessary precautions can be taken before the disease becomes severe.

 Objective: Approximately 80 of people with coronavirus disease 2019 COVID-19 are asymptomatic, and only a small proportion of cases show serious consequences leading to hospitalization. The interplay between chemokines and their receptors can affect the severity of several infectious diseases, such as severe acute respiratory syndrome and Middle East Respiratory Syndrome. The interplay of monocyte chemoattractant protein-1 MCP-1 with its receptor C-C motif chemokine receptor 2 CCR2 may affect the pathogenesis of COVID-19 by functioning in the dispatch of lymphocytes and monocytesmacrophages to the infection site. Materials and Methods: The serum MCP-1 and CCR2 concentrations were measured using the enzyme-linked immunosorbent assay ELISA in 49 asymptomatic, 50 severe, and 57 critical COVID-19 cases. Results: Serum MCP-1 levels were considerably higher in critical cases than in cases in the other two groups, suggesting an increased risk for disease severity p  0.008; p  0.01, respectively. Serum CCR2 levels were significantly higher in asymptomatic cases than in critical cases suggesting a protective role against disease severity p  0.001. Conclusion: MCP-1 and CCR2 may be candidate biomarkers for the prediction of disease severity. Therefore, by measuring serum levels of MCP-1 and CCR2 early, the disease course can be predicted , and necessary precautions can be taken before the disease becomes severe.

 Objective: Approximately 80 of people with coronavirus disease 2019 COVID-19 are asymptomatic, and only a small proportion of cases show serious consequences leading to hospitalization. The interplay between chemokines and their receptors can affect the severity of several infectious diseases, such as severe acute respiratory syndrome and Middle East Respiratory Syndrome. The interplay of monocyte chemoattractant protein-1 MCP-1 with its receptor C-C motif chemokine receptor 2 CCR2 may affect the pathogenesis of COVID-19 by functioning in the dispatch of lymphocytes and monocytesmacrophages to the infection site. Materials and Methods: The serum MCP-1 and CCR2 concentrations were measured using the enzyme-linked immunosorbent assay ELISA in 49 asymptomatic, 50 severe, and 57 critical COVID-19 cases. Results: Serum MCP-1 levels were considerably higher in critical cases than in cases in the other two groups, suggesting an increased risk for disease severity p  0.008; p  0.01, respectively. Serum CCR2 levels were significantly higher in asymptomatic cases than in critical cases suggesting a protective role against disease severity p  0.001. Conclusion: MCP-1 and CCR2 may be candidate biomarkers for the prediction of disease severity. Therefore, by measuring serum levels of MCP-1 and CCR2 early, the disease course can be predicted , and necessary precautions can be taken before the disease becomes severe.

 Objective: Approximately 80 of people with coronavirus disease 2019 COVID-19 are asymptomatic, and only a small proportion of cases show serious consequences leading to hospitalization. The interplay between chemokines and their receptors can affect the severity of several infectious diseases, such as severe acute respiratory syndrome and Middle East Respiratory Syndrome. The interplay of monocyte chemoattractant protein-1 MCP-1 with its receptor C-C motif chemokine receptor 2 CCR2 may affect the pathogenesis of COVID-19 by functioning in the dispatch of lymphocytes and monocytesmacrophages to the infection site. Materials and Methods: The serum MCP-1 and CCR2 concentrations were measured using the enzyme-linked immunosorbent assay ELISA in 49 asymptomatic, 50 severe, and 57 critical COVID-19 cases. Results: Serum MCP-1 levels were considerably higher in critical cases than in cases in the other two groups, suggesting an increased risk for disease severity p  0.008; p  0.01, respectively. Serum CCR2 levels were significantly higher in asymptomatic cases than in critical cases suggesting a protective role against disease severity p  0.001. Conclusion: MCP-1 and CCR2 may be candidate biomarkers for the prediction of disease severity. Therefore, by measuring serum levels of MCP-1 and CCR2 early, the disease course can be predicted , and necessary precautions can be taken before the disease becomes severe.

Makale detayları

Effect of MCP-1 and CCR2 Serum Levels on COVID-19 Severity

Yazarlar:

Selen Zeliha Mart Kömürcü | Şeydanur Doğan | Ebru Kaya | Sevim Yavaş | Serkan Doğan | Utku Murat Kalafat | Hayriye Şentürk Çiftçi | Selçuk Daşdemir

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Experimed Vol.13 Issue 3, pp.276-280

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310805

pISSN:

2667-5846

MCP-1

CCR2

COVID-19 severity

risk factors

candidate biomarkers

Sayı

Makale detayları

Effect of MCP-1 and CCR2 Serum Levels on COVID-19 Severity

Yazarlar: Selen Zeliha Mart Kömürcü | Şeydanur Doğan | Ebru Kaya | Sevim Yavaş | Serkan Doğan | Utku Murat Kalafat | Hayriye Şentürk Çiftçi | Selçuk Daşdemir

Yayıncı: Istanbul University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Experimed Vol.13 Issue 3, pp.276-280

Belge Tipi: Makale

Yayın Tarihi: 12/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001310805

pISSN: 2667-5846

MCP-1

CCR2

COVID-19 severity

risk factors

candidate biomarkers

Sayı

Yazarlar:

Selen Zeliha Mart Kömürcü | Şeydanur Doğan | Ebru Kaya | Sevim Yavaş | Serkan Doğan | Utku Murat Kalafat | Hayriye Şentürk Çiftçi | Selçuk Daşdemir

Yayıncı:

Istanbul University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Experimed Vol.13 Issue 3, pp.276-280

Belge Tipi:

Makale

Yayın Tarihi:

12/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001310805

pISSN:

2667-5846