Synthesis and Antioxidant Activities of Some Novel 1-(Morpholine-4-il-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

Sevda MANAP; Fevzi AYTEMIZ; Haydar YUKSEK

Makale detayları

Synthesis and Antioxidant Activities of Some Novel 1-(Morpholine-4-il-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

Yazarlar:

Sevda MANAP | Fevzi AYTEMIZ | Haydar YUKSEK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

The Eurasia Proceedings of Science Technology Engineering and Mathematics 2018 Issue 2, pp.135-142

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000661142

Özet:

 


In this study, 3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones
(1) were treated with morpholine in the presence of formaldehyde according to
the Mannich reaction to synthesize five novel
1-(morpholine-4-yl-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2). In addition, the antioxidant properties of compounds 2 were analyzed and evaluated using three antioxidant assays,
including reducing power, free radical scavenging and metal chelating activity.
For the measurement of the reductive ability, Fe3+-Fe2+
transformation was investigated in the presence of compound using by the method
of Oyaizu (1986). The hydrogen atoms or
electrons donation ability of the synthesized compound was measured by DPPH. using the method of Blois (1958). The chelating effect of ferrous ions by the
compound was determined according to the method of Dinis, Madeira & Almeida (1994). BHT, BHA, EDTA and α-tocopherol
were used as reference antioxidant compounds.

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Makale detayları

Synthesis and Antioxidant Activities of Some Novel 1-(Morpholine-4-il-methyl)-3-alkyl(aryl)-4-(3-methoxy-4-isobutyryloxy)benzylideneamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

Yazarlar: Sevda MANAP | Fevzi AYTEMIZ | Haydar YUKSEK

Ana Başlıklar: Uygulamalı fizik

Dergi: The Eurasia Proceedings of Science Technology Engineering and Mathematics 2018 Issue 2, pp.135-142

Belge Tipi: Makale

Yayın Tarihi: 8/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000661142

Sayı

Yazarlar:

Sevda MANAP | Fevzi AYTEMIZ | Haydar YUKSEK

Ana Başlıklar:

Uygulamalı fizik

Dergi:

The Eurasia Proceedings of Science Technology Engineering and Mathematics 2018 Issue 2, pp.135-142

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000661142