Evaluation of platelet indices in chronic kidney disease

Mahmut Egemen Senel; Ertuğrul Erken; İlyas Ozturk; Neziha Ulusoylar Erken; Orçun Altunören

Makale detayları

Evaluation of platelet indices in chronic kidney disease

Yazarlar:

Mahmut Egemen Senel | Ertuğrul Erken | İlyas Ozturk | Neziha Ulusoylar Erken | Orçun Altunören

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Internal Diseases

Dergi:

Interdisciplinary Medical Journal Vol.15 Issue 52, pp.72-79

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326513

pISSN:

2980-1915

Anahtar kelimeler:

Özet:

 Objective: Chronic kidney disease CKD is characterized by an irreversible decrease in kidney functions and accumulation of uremic toxins in the body. Platelet indices have the potential to predict the inflammatory status and disease progression in patients with CKD. In this study it was aimed to investigate platelet indices and their relations with renal function and comorbid conditions in CKD patients. Method: In this study it was included 411 CKD patients. We looked for associations between platelet indices and estimated glomerular filtration rate eGFR. We generated linear regression models for platelet indices that may be associated with eGFR. We evaluated CKD patients for possible associations between platelet indices and comorbid conditions such as diabetes, hypertension, and cardiovascular diseases. Results: The mean age of CKD patients was 60.5 and the GFR value was 40.124.8 mLmin1.73m2. While the mean platelet count, MPV, PCT, PDW, P-LCR values were lower in the advanced CKD group, hematocrit adjusted platelet count HAPC, MPVLymphocyte ratio and SII parameters were higher in the advanced CKD group p0.05 for all. In analyzes a positive correlation was detected between eGFR and HAPC, and a negative correlation was detected between MPVLymphocyte ratio and eGFR p0.001 and p0.036. MPV, PCT, PDW, P-LCR and SII index were observed to be higher in diabetic CKD patients p0.05 for all. Conclusion: Platelet indices have the potential to provide valuable data about chronic diseases and their complications. MPVLymphocyte ratio and HAPC can give an idea about CKD progression. Our findings suggest that elevations in platelet volume indices could be indicative of diabetic nephropathy and increased inflammatory status.

 Objective: Chronic kidney disease CKD is characterized by an irreversible decrease in kidney functions and accumulation of uremic toxins in the body. Platelet indices have the potential to predict the inflammatory status and disease progression in patients with CKD. In this study it was aimed to investigate platelet indices and their relations with renal function and comorbid conditions in CKD patients. Method: In this study it was included 411 CKD patients. We looked for associations between platelet indices and estimated glomerular filtration rate eGFR. We generated linear regression models for platelet indices that may be associated with eGFR. We evaluated CKD patients for possible associations between platelet indices and comorbid conditions such as diabetes, hypertension, and cardiovascular diseases. Results: The mean age of CKD patients was 60.5 and the GFR value was 40.124.8 mLmin1.73m2. While the mean platelet count, MPV, PCT, PDW, P-LCR values were lower in the advanced CKD group, hematocrit adjusted platelet count HAPC, MPVLymphocyte ratio and SII parameters were higher in the advanced CKD group p0.05 for all. In analyzes a positive correlation was detected between eGFR and HAPC, and a negative correlation was detected between MPVLymphocyte ratio and eGFR p0.001 and p0.036. MPV, PCT, PDW, P-LCR and SII index were observed to be higher in diabetic CKD patients p0.05 for all. Conclusion: Platelet indices have the potential to provide valuable data about chronic diseases and their complications. MPVLymphocyte ratio and HAPC can give an idea about CKD progression. Our findings suggest that elevations in platelet volume indices could be indicative of diabetic nephropathy and increased inflammatory status.

 Objective: Chronic kidney disease CKD is characterized by an irreversible decrease in kidney functions and accumulation of uremic toxins in the body. Platelet indices have the potential to predict the inflammatory status and disease progression in patients with CKD. In this study it was aimed to investigate platelet indices and their relations with renal function and comorbid conditions in CKD patients. Method: In this study it was included 411 CKD patients. We looked for associations between platelet indices and estimated glomerular filtration rate eGFR. We generated linear regression models for platelet indices that may be associated with eGFR. We evaluated CKD patients for possible associations between platelet indices and comorbid conditions such as diabetes, hypertension, and cardiovascular diseases. Results: The mean age of CKD patients was 60.5 and the GFR value was 40.124.8 mLmin1.73m2. While the mean platelet count, MPV, PCT, PDW, P-LCR values were lower in the advanced CKD group, hematocrit adjusted platelet count HAPC, MPVLymphocyte ratio and SII parameters were higher in the advanced CKD group p0.05 for all. In analyzes a positive correlation was detected between eGFR and HAPC, and a negative correlation was detected between MPVLymphocyte ratio and eGFR p0.001 and p0.036. MPV, PCT, PDW, P-LCR and SII index were observed to be higher in diabetic CKD patients p0.05 for all. Conclusion: Platelet indices have the potential to provide valuable data about chronic diseases and their complications. MPVLymphocyte ratio and HAPC can give an idea about CKD progression. Our findings suggest that elevations in platelet volume indices could be indicative of diabetic nephropathy and increased inflammatory status.

 Objective: Chronic kidney disease CKD is characterized by an irreversible decrease in kidney functions and accumulation of uremic toxins in the body. Platelet indices have the potential to predict the inflammatory status and disease progression in patients with CKD. In this study it was aimed to investigate platelet indices and their relations with renal function and comorbid conditions in CKD patients. Method: In this study it was included 411 CKD patients. We looked for associations between platelet indices and estimated glomerular filtration rate eGFR. We generated linear regression models for platelet indices that may be associated with eGFR. We evaluated CKD patients for possible associations between platelet indices and comorbid conditions such as diabetes, hypertension, and cardiovascular diseases. Results: The mean age of CKD patients was 60.5 and the GFR value was 40.124.8 mLmin1.73m2. While the mean platelet count, MPV, PCT, PDW, P-LCR values were lower in the advanced CKD group, hematocrit adjusted platelet count HAPC, MPVLymphocyte ratio and SII parameters were higher in the advanced CKD group p0.05 for all. In analyzes a positive correlation was detected between eGFR and HAPC, and a negative correlation was detected between MPVLymphocyte ratio and eGFR p0.001 and p0.036. MPV, PCT, PDW, P-LCR and SII index were observed to be higher in diabetic CKD patients p0.05 for all. Conclusion: Platelet indices have the potential to provide valuable data about chronic diseases and their complications. MPVLymphocyte ratio and HAPC can give an idea about CKD progression. Our findings suggest that elevations in platelet volume indices could be indicative of diabetic nephropathy and increased inflammatory status.

Makale detayları

Evaluation of platelet indices in chronic kidney disease

Yazarlar:

Mahmut Egemen Senel | Ertuğrul Erken | İlyas Ozturk | Neziha Ulusoylar Erken | Orçun Altunören

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Internal Diseases

Dergi:

Interdisciplinary Medical Journal Vol.15 Issue 52, pp.72-79

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326513

pISSN:

2980-1915

Hematocrit adjusted platelet count

mean platelet volume

platelet indices

systemic immune-inflamation index

Sayı

Makale detayları

Evaluation of platelet indices in chronic kidney disease

Yazarlar: Mahmut Egemen Senel | Ertuğrul Erken | İlyas Ozturk | Neziha Ulusoylar Erken | Orçun Altunören

Yayıncı: Hatay Mustafa Kemal University

Ana Başlıklar: Internal Diseases

Dergi: Interdisciplinary Medical Journal Vol.15 Issue 52, pp.72-79

Belge Tipi: Makale

Yayın Tarihi: 2/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001326513

pISSN: 2980-1915

Hematocrit adjusted platelet count

mean platelet volume

platelet indices

systemic immune-inflamation index

Sayı

Yazarlar:

Mahmut Egemen Senel | Ertuğrul Erken | İlyas Ozturk | Neziha Ulusoylar Erken | Orçun Altunören

Yayıncı:

Hatay Mustafa Kemal University

Ana Başlıklar:

Internal Diseases

Dergi:

Interdisciplinary Medical Journal Vol.15 Issue 52, pp.72-79

Belge Tipi:

Makale

Yayın Tarihi:

2/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326513

pISSN:

2980-1915