Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Fatih Tok; Elif Kaya Tilki; Miriş Dikmen; Bedia Kaymakçıoğlu

Makale detayları

Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Yazarlar:

Fatih Tok | Elif Kaya Tilki | Miriş Dikmen | Bedia Kaymakçıoğlu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.13-19

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346099

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 In this study, some new carbohydrazide derivatives bearing furan moiety were synthesized. All carbohydrazide structures have been characterized by IR, 1H-NMR and elemental analysis. Anticancer activity of compounds were investigated on A549 human lung cancer and BJ normal fibroblast cells. According to the MTT assay results, all compounds demonstrated the cytotoxic activity on A549 cells with IC50 values of 43.38-342.63 µM except compound 3g. Only the IC50 values of compound 3c was below 400 µM on BJ cells. Especially, compound 3e showed significant anticancer effects on A549 cells with IC50 value of 43.38 µM and also didnt show cytotoxic effects on normal BJ cells.

 In this study, some new carbohydrazide derivatives bearing furan moiety were synthesized. All carbohydrazide structures have been characterized by IR, 1H-NMR and elemental analysis. Anticancer activity of compounds were investigated on A549 human lung cancer and BJ normal fibroblast cells. According to the MTT assay results, all compounds demonstrated the cytotoxic activity on A549 cells with IC50 values of 43.38-342.63 µM except compound 3g. Only the IC50 values of compound 3c was below 400 µM on BJ cells. Especially, compound 3e showed significant anticancer effects on A549 cells with IC50 value of 43.38 µM and also didnt show cytotoxic effects on normal BJ cells.

 In this study, some new carbohydrazide derivatives bearing furan moiety were synthesized. All carbohydrazide structures have been characterized by IR, 1H-NMR and elemental analysis. Anticancer activity of compounds were investigated on A549 human lung cancer and BJ normal fibroblast cells. According to the MTT assay results, all compounds demonstrated the cytotoxic activity on A549 cells with IC50 values of 43.38-342.63 µM except compound 3g. Only the IC50 values of compound 3c was below 400 µM on BJ cells. Especially, compound 3e showed significant anticancer effects on A549 cells with IC50 value of 43.38 µM and also didnt show cytotoxic effects on normal BJ cells.

 In this study, some new carbohydrazide derivatives bearing furan moiety were synthesized. All carbohydrazide structures have been characterized by IR, 1H-NMR and elemental analysis. Anticancer activity of compounds were investigated on A549 human lung cancer and BJ normal fibroblast cells. According to the MTT assay results, all compounds demonstrated the cytotoxic activity on A549 cells with IC50 values of 43.38-342.63 µM except compound 3g. Only the IC50 values of compound 3c was below 400 µM on BJ cells. Especially, compound 3e showed significant anticancer effects on A549 cells with IC50 value of 43.38 µM and also didnt show cytotoxic effects on normal BJ cells.

Makale detayları

Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Yazarlar:

Fatih Tok | Elif Kaya Tilki | Miriş Dikmen | Bedia Kaymakçıoğlu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.13-19

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346099

pISSN:

2630-6344

Amide

furan

anticancer

carbohydrazide

Sayı

Makale detayları

Synthesis and anticancer activity of new carbohydrazide derivatives bearing furan moiety

Yazarlar: Fatih Tok | Elif Kaya Tilki | Miriş Dikmen | Bedia Kaymakçıoğlu

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.26 Issue 1, pp.13-19

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001346099

pISSN: 2630-6344

Amide

furan

anticancer

carbohydrazide

Sayı

Yazarlar:

Fatih Tok | Elif Kaya Tilki | Miriş Dikmen | Bedia Kaymakçıoğlu

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.26 Issue 1, pp.13-19

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001346099

pISSN:

2630-6344