Investigation of effects of neurotrophic factors on painful diabetic neuropathy: an experimental study

Faruk KILINÇ; Ramis ÇOLAK; Mete ÖZCAN; Ahmet AYAR

doi:https://doi.org/10.18621/eurj.414105

Makale detayları

Investigation of effects of neurotrophic factors on painful diabetic neuropathy: an experimental study

Yazarlar:

Faruk KILINÇ | Ramis ÇOLAK | Mete ÖZCAN | Ahmet AYAR

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2019 Vol.5 Issue 4, pp.641-648

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000662673

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.414105

Özet:

 


Objective: We have studied the effects of neurotrophin-4 (NT-4)
different doses on the pain levels of streptozocin-induced diabetic rats. 


Methods: Thirty-five 3-week-old male rats were used. After
induction of diabetes in rats with streptozocin (nearly 4 weeks); diabetic
animals were divided into 4 groups. The first group; healthy control group (n =
15 ), the second group; diabetic control group ( n = 10 ), the third group; low
dose (0.3 mg/ kg ) recombinant human NT-4 was applied ( n = 4 ) and the fourth
group; high dose recombinant human NT-4 was applied (n = 6). 


Results: In the low-dose NT-4 group, the pain threshold values
did not differ from the diabetic control and healthy control groups. In the
high dose NT-4 group, a rise was observed in the pain threshold values of hot
plate in comparison with the healthy control group, diabetic control group and
low dose applied group and this rise reached at the level of statistical
significance (p < 0.05). 


Conclusion: Neurotrophic factors (neurotrophin-4) have been shown
to be effective on painful diabetic neuropathy in streptozocin-induced diabetic
rats. However, there is a need for larger-scale and longer-term studies for
clinical use. 


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Makale detayları

Investigation of effects of neurotrophic factors on painful diabetic neuropathy: an experimental study

Yazarlar: Faruk KILINÇ | Ramis ÇOLAK | Mete ÖZCAN | Ahmet AYAR

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Sağlık teşvikleri

Dergi: The European Research Journal 2019 Vol.5 Issue 4, pp.641-648

Belge Tipi: Makale

Yayın Tarihi: 7/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000662673

Sıklık: İki Aylık

eISSN: 2149-3189

DOI: https://doi.org/10.18621/eurj.414105

Sayı

Yazarlar:

Faruk KILINÇ | Ramis ÇOLAK | Mete ÖZCAN | Ahmet AYAR

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The European Research Journal 2019 Vol.5 Issue 4, pp.641-648

Belge Tipi:

Makale

Yayın Tarihi:

7/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000662673

Sıklık:

İki Aylık

eISSN:

2149-3189

DOI:

https://doi.org/10.18621/eurj.414105