The combination of fatty liver and increased gamma-glutamyl transpeptidase levels as a risk factor for atherosclerotic plaque development in apparently healthy people

Kaori KINOSHITA; Nobuyuki TOSHIKUNI; Takashi SAITO; Nobuhiko HAYASHI; Takahiro MINATO; Yasuhiro MATSUE; Yoshimichi UEDA; Mutsumi TSUCHISHIMA; Mikihiro TSUTSUMI

Makale detayları

The combination of fatty liver and increased gamma-glutamyl transpeptidase levels as a risk factor for atherosclerotic plaque development in apparently healthy people

Yazarlar:

Kaori KINOSHITA | Nobuyuki TOSHIKUNI | Takashi SAITO | Nobuhiko HAYASHI | Takahiro MINATO | Yasuhiro MATSUE | Yoshimichi UEDA | Mutsumi TSUCHISHIMA | Mikihiro TSUTSUMI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1350-1357

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749849

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim: To elucidate how the combination of fatty liver and increased serum gamma-glutamyl transpeptidase (GGT) levels influences atherosclerotic plaque development in apparently healthy people.Materials and methods: The study population included people who had received an annual health checkup for more than 7 years and had no evidence of carotid plaque at baseline. We investigated the risk factors for carotid plaque occurrence using the Cox proportional hazards model.Results: A total of 107 people (76 men and 31 women; median age, 49 years) were enrolled. At baseline, fatty liver and a serum GGT level ≥50 U/L were observed in 13 and 38 people, respectively. During a median follow-up period of 13.3 years, carotid plaques appeared in 34 people. Multivariate analysis revealed that the combination of fatty liver and a serum GGT level ≥50 U/L was the only significant risk factor for carotid plaque occurrence (age- and sex-adjusted hazard ratio: 5.55; 95% confidence interval 1.70-18.14; P = 0.005).Conclusion: The combination of fatty liver and increased serum GGT levels raises the risk for atherosclerotic plaque development in apparently healthy people.

Makale detayları

The combination of fatty liver and increased gamma-glutamyl transpeptidase levels as a risk factor for atherosclerotic plaque development in apparently healthy people

Yazarlar: Kaori KINOSHITA | Nobuyuki TOSHIKUNI | Takashi SAITO | Nobuhiko HAYASHI | Takahiro MINATO | Yasuhiro MATSUE | Yoshimichi UEDA | Mutsumi TSUCHISHIMA | Mikihiro TSUTSUMI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1350-1357

Belge Tipi: Makale

Yayın Tarihi: 9/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000749849

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Kaori KINOSHITA | Nobuyuki TOSHIKUNI | Takashi SAITO | Nobuhiko HAYASHI | Takahiro MINATO | Yasuhiro MATSUE | Yoshimichi UEDA | Mutsumi TSUCHISHIMA | Mikihiro TSUTSUMI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 5, pp.1350-1357

Belge Tipi:

Makale

Yayın Tarihi:

9/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000749849

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144