Some New Bis-(1,2,4-Triazole) Compounds: Synthesis, Characterization and Urease Enzyme Inhibition

Nesrin Ünal Karaali; Havva Nur Cihangir

Makale detayları

Some New Bis-(1,2,4-Triazole) Compounds: Synthesis, Characterization and Urease Enzyme Inhibition

Yazarlar:

Nesrin Ünal Karaali | Havva Nur Cihangir

Yayıncı:

Giresun University

Ana Başlıklar:

Fiziksel Kimya (Diğer)

Dergi:

Karadeniz Fen Bilimleri Dergisi Vol.14 Issue 3, pp.1360-1370

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326808

pISSN:

2564-7377

Anahtar kelimeler:

Özet:

 In this study, thiosemicarbazide derivatives 2a-c were obtained from the reaction of acetohydrazide derivative 1,2,4-triazole compound 1 with methyl isothiocyanate, phenyl isothiocyanate, and 4-methylphenyl isothiocyanate compounds, respectively. Then, by intramolecular cyclization of 2a-c compounds, bis-1,2,4-triazole compounds 3a-c were synthesized. The synthesized compounds chemical structures were verified using FT-IR, 1H-NMR, and 13C-NMR spectroscopic methods. In addition, the urease enzyme inhibition of the synthesized compounds was evaluated using the Weatherburn method in vitro. All newly synthesized compounds showed urease enzyme inhibition in the range of 15.00  0.10 to 16.00  0.25 IC50 µgmL compared to standard thiourea IC50  15.75  0.15 µgmL.

 In this study, thiosemicarbazide derivatives 2a-c were obtained from the reaction of acetohydrazide derivative 1,2,4-triazole compound 1 with methyl isothiocyanate, phenyl isothiocyanate, and 4-methylphenyl isothiocyanate compounds, respectively. Then, by intramolecular cyclization of 2a-c compounds, bis-1,2,4-triazole compounds 3a-c were synthesized. The synthesized compounds chemical structures were verified using FT-IR, 1H-NMR, and 13C-NMR spectroscopic methods. In addition, the urease enzyme inhibition of the synthesized compounds was evaluated using the Weatherburn method in vitro. All newly synthesized compounds showed urease enzyme inhibition in the range of 15.00  0.10 to 16.00  0.25 IC50 µgmL compared to standard thiourea IC50  15.75  0.15 µgmL.

 In this study, thiosemicarbazide derivatives 2a-c were obtained from the reaction of acetohydrazide derivative 1,2,4-triazole compound 1 with methyl isothiocyanate, phenyl isothiocyanate, and 4-methylphenyl isothiocyanate compounds, respectively. Then, by intramolecular cyclization of 2a-c compounds, bis-1,2,4-triazole compounds 3a-c were synthesized. The synthesized compounds chemical structures were verified using FT-IR, 1H-NMR, and 13C-NMR spectroscopic methods. In addition, the urease enzyme inhibition of the synthesized compounds was evaluated using the Weatherburn method in vitro. All newly synthesized compounds showed urease enzyme inhibition in the range of 15.00  0.10 to 16.00  0.25 IC50 µgmL compared to standard thiourea IC50  15.75  0.15 µgmL.

 Bu çalışmada, asetohidrazid türevi 1,2,4-triazol bileşiğinin 1 sırasıyla etilizotiyosiyanat, fenilizotiyosiyanat ve 4-etilfenilizotiyosiyanat bileşikleri ile reaksiyonundan tiyosemikarbazid türevleri 2a-c elde edilmiştir. Daha sonra, 2a-c bileşiklerinin intramoleküler siklizasyonu ile bis-1,2,4-triazol bileşikleri 3a-c sentezlenmiştir. Sentezlenen bileşiklerin kimyasal yapıları FT-IR, 1H-NMR ve 13C-NMR spektroskopik yöntemleri kullanılarak doğrulandı. Ayrıca, sentezlenen bileşiklerin üreaz enzimi inhibisyonu in vitro Weatherburn yöntemi kullanılarak değerlendirildi. Yeni sentezlenen tüm bileşikler, standart tiyoüre IC50 µgmL: 15.75  0.15 ile karşılaştırıldığında 15.00  0.10 ila 16.00  0.25 IC50 µgmL aralığında üreaz enzim inhibisyonu göstermiştir.

Makale detayları

Some New Bis-(1,2,4-Triazole) Compounds: Synthesis, Characterization and Urease Enzyme Inhibition

Yazarlar:

Nesrin Ünal Karaali | Havva Nur Cihangir

Yayıncı:

Giresun University

Ana Başlıklar:

Fiziksel Kimya (Diğer)

Dergi:

Karadeniz Fen Bilimleri Dergisi Vol.14 Issue 3, pp.1360-1370

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326808

pISSN:

2564-7377

Bis-(1,2,4-triazole)

Isothiocyanate

Thiosemicarbazide

Ureaseİzotiyosiyanat

Tiyosemikarbazi

Üreaz.

Bis-(1,2,4-triazol)

Sayı

Makale detayları

Yazarlar: Nesrin Ünal Karaali | Havva Nur Cihangir

Yayıncı: Giresun University

Ana Başlıklar: Fiziksel Kimya (Diğer)

Dergi: Karadeniz Fen Bilimleri Dergisi Vol.14 Issue 3, pp.1360-1370

Belge Tipi: Makale

Yayın Tarihi: 9/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001326808

pISSN: 2564-7377

Sayı

Yazarlar:

Nesrin Ünal Karaali | Havva Nur Cihangir

Yayıncı:

Giresun University

Ana Başlıklar:

Fiziksel Kimya (Diğer)

Dergi:

Karadeniz Fen Bilimleri Dergisi Vol.14 Issue 3, pp.1360-1370

Belge Tipi:

Makale

Yayın Tarihi:

9/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001326808

pISSN:

2564-7377