Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas

İrfan CİCİN; Tahsin ÖZATLI; Esma TÜRKMEN; Türkan ÖZTURK; Melike ÖZÇELİK; Devrim ÇABUK; Ayşe GÖKDURNALI; Özlem BALVAN; Yaşar YILDIZ; Metin ŞEKER; Nuriye ÖZDEMİR; Burcu YAPAR; Özgür TANRIVERDİ; Yusuf GÜNAYDİN; Serkan MENEKŞE; Berna ÖKSÜZOĞLU; Asude AKSOY; Bülent ERDOĞAN; M. Bekir HACIOGLU; Erkan ARPACİ; Alper SEVİNÇ; Mehmet Atilla UYSAL; Sinem İLİAZ

Makale detayları

Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas

Yazarlar:

İrfan CİCİN | Tahsin ÖZATLI | Esma TÜRKMEN | Türkan ÖZTURK | Melike ÖZÇELİK | Devrim ÇABUK | Ayşe GÖKDURNALI | Özlem BALVAN | Yaşar YILDIZ | Metin ŞEKER | Nuriye ÖZDEMİR | Burcu YAPAR | Özgür TANRIVERDİ | Yusuf GÜNAYDİN | Serkan MENEKŞE | Berna ÖKSÜZOĞLU | Asude AKSOY | Bülent ERDOĞAN | M. Bekir HACIOGLU | Erkan ARPACİ | Alper SEVİNÇ | Mehmet Atilla UYSAL | Sinem İLİAZ

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2016 Vol.33 Issue 5, pp.517-524

Belge Tipi:

Makale

Yayın Tarihi:

8/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000759408

Sıklık:

İki Aylık

pISSN:

2146-3123

Özet:

 

Background: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT.     Aims: We aimed to define the prognostic and predictive factors associated with treatment options in ovarian (OCS) and uterine carcinosarcoma (UCS).     Study Design: Retrospective cross-sectional study     Methods: We retrospectively reviewed the medical records of patients with ovarian and uterine carcinosarcoma from 2000 to 2013, and 127 women were included in this study (24 ovarian and 103 uterine). Patients admitted to seventeen oncology centres in Turkey between 2000 and December 2013 with a histologically proven diagnosis of uterine carcinosarcoma with FIGO 2009 stage I-III and patients with sufficient data obtained from well-kept medical records were included in this study. Stage IV tumours were excluded. The patient records were retrospectively reviewed. Data from 104 patients were evaluated for this study.     Results: Age (≥70 years) was a poor prognostic factor for UCS (p=0.036). Pelvic±para aortic lymph node dissection did not affect overall survival (OS) (p=0.35). Macroscopic residual disease was related with OS (p<0.01). The median OS was significantly longer in stage I-II patients than stage III patients (p=0.03). Adjuvant treatment improved OS (p=0.013). Adjuvant radiotherapy tended to increase the median OS (p=0.075). However, this tendency was observed in UCS (p=0.08) rather than OCS (p=0.6).Adjuvant chemotherapy had no effect on OS (p=0.15).Adjuvant radiotherapy significantly prolonged the median OS in patients with endometrioid component (p=0.034). A serous/clear cell component was a negative prognostic factor (p=0.035). Patients with serous/clear cell histology for whom adjuvant chemotherapy was applied had significantly longer OS (p=0.019), and there was no beneficial effect of adjuvant radiotherapy (p=0.4). Adjuvant chemotherapy was effective in heterologous tumours (p=0.026). In multivariate analysis, the stage and chemotherapy were prognostic factors for all patients. Age was an independent prognostic factor for UCS. However, serous/clear cell histology and radiotherapy tended to be significant prognostic factors.     Conclusion: The primary location, the histological type of sarcomatous and the epithelial component may be predictive factors for the efficacy of chemotherapy or radiotherapy in UCS and OCS.

Makale detayları

Predictive and Prognostic Factors in Ovarian and Uterine Carcinosarcomas

Yayıncı: Trakya University

Dergi: Balkan Medical Journal 2016 Vol.33 Issue 5, pp.517-524

Belge Tipi: Makale

Yayın Tarihi: 8/2016

Belge Dili: Türkçe

Document ID (Org No.): 2000759408

Sıklık: İki Aylık

pISSN: 2146-3123

Sayı

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2016 Vol.33 Issue 5, pp.517-524

Belge Tipi:

Makale

Yayın Tarihi:

8/2016

Belge Dili:

Türkçe

Document ID (Org No.):

2000759408

Sıklık:

İki Aylık

pISSN:

2146-3123