Hormonal Profile and Agnor Values in Pituitary Adenomas

Sema HÜCÜMENOĞLU

Makale detayları

Hormonal Profile and Agnor Values in Pituitary Adenomas

Yazarlar:

Sema HÜCÜMENOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2001 Vol.31 Issue 6, pp.523-528

Belge Tipi:

Makale

Yayın Tarihi:

5/2001

Belge Dili:

Türkçe

Document ID (Org No.):

2000757142

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Nucleolar organizer regions (NORs) are chromosomal segments in which ribosomal RNA is encoded.  The AgNOR technique,  which reveals these regions,  has rarely been used in diagnosis and preceding the prognosis of pituitary adenoma.  The purpose of this study was to evaluate the correlation of hormonal profile with the AgNOR counts, and the correlation of recurrence with the AgNOR counts and to determine the concordance between the evaluations of two different observers.  This study included 33 patients wıth pituitary adenoma.  The slides were stained with hematoxylin and eosin,  silver colloid method for NORs and immunohistochemistry for the  hormone expressions.  Consistency was strong among the two pathologists (for hormonal profiling, the kappa test was used and p0. 05).  In addition, we found no difference between recurrent patients and non-recurrent ones in terms of mean AgNOR numbers (p>0. 05). However, in recurrent patients,  nucleolar silver staining was more frequently detected as clusters of AgNORs.

 

Nucleolar organizer regions (NORs) are chromosomal segments in which ribosomal RNA is encoded.  The AgNOR technique,  which reveals these regions,  has rarely been used in diagnosis and preceding the prognosis of pituitary adenoma.  The purpose of this study was to evaluate the correlation of hormonal profile with the AgNOR counts, and the correlation of recurrence with the AgNOR counts and to determine the concordance between the evaluations of two different observers.  This study included 33 patients wıth pituitary adenoma.  The slides were stained with hematoxylin and eosin,  silver colloid method for NORs and immunohistochemistry for the  hormone expressions.  Consistency was strong among the two pathologists (for hormonal profiling, the kappa test was used and p0. 05).  In addition, we found no difference between recurrent patients and non-recurrent ones in terms of mean AgNOR numbers (p>0. 05). However, in recurrent patients,  nucleolar silver staining was more frequently detected as clusters of AgNORs.

Makale detayları

Hormonal Profile and Agnor Values in Pituitary Adenomas

Yazarlar:

Sema HÜCÜMENOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2001 Vol.31 Issue 6, pp.523-528

Belge Tipi:

Makale

Yayın Tarihi:

5/2001

Belge Dili:

Türkçe

Document ID (Org No.):

2000757142

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Pituitary adenoma

AgNOR

immunohistochemistry

recurrence.

Sayı

Makale detayları

Hormonal Profile and Agnor Values in Pituitary Adenomas

Yazarlar: Sema HÜCÜMENOĞLU

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2001 Vol.31 Issue 6, pp.523-528

Belge Tipi: Makale

Yayın Tarihi: 5/2001

Belge Dili: Türkçe

Document ID (Org No.): 2000757142

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Pituitary adenoma

AgNOR

immunohistochemistry

recurrence.

Sayı

Yazarlar:

Sema HÜCÜMENOĞLU

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2001 Vol.31 Issue 6, pp.523-528

Belge Tipi:

Makale

Yayın Tarihi:

5/2001

Belge Dili:

Türkçe

Document ID (Org No.):

2000757142

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144