The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model

N.A.

Makale detayları

The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model

Yazarlar:

N.A.

Yayıncı:

Yildiz Technical University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Sigma Journal of Engineering and Natural Sciences Vol.42 Issue 2, pp.497-502

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316871

pISSN:

1304-7191

Anahtar kelimeler:

Özet:

 This study evaluates the protective effect of Hesperidin HES, flavanoglycone, during pre-ec-lampsia developed pregnancy. The pregnant rats were randomly divided into five groups as Control, L-NAME 25 mgkg, HES 100 mgkg, L-NAME-HES and L-NAME P-HES. After the 13th day of pregnancy, the chemicals were administrated until the 20th day. 20 days after the offsprings birth, they were separated from their mothers and all rats were sacrificed after 6 weeks time. Serum samples were analyzed for levels of Glutathione GSH, lipid peroxidation LPO, and neuron-specific enolase NSE activity. Urine samples were analyzed for the pro-teinuria. While Proteinuria and LPO level increasing, GSH levels decreased in the L-NAME group when compared to the Control. As we compared L-NAME group with the L-NAME-HES and L-NAME P-HES groups, the GSH levels increased significantly while LPO levels in the HES, L-NAME-HES, L-NAME P-HES groups were decreasing. The NSE activity signifi-cantly increased in the L-NAME group compared to the Control. In contrast to the L-NAME group, its activity decreased in HES, L-NAME-HES and L-NAME P-HES groups significantly. Briefly, it can be said that HES has a significant effect on both the LPO levels and the NSE activity in the case of pre-eclampsia.

 This study evaluates the protective effect of Hesperidin HES, flavanoglycone, during pre-ec-lampsia developed pregnancy. The pregnant rats were randomly divided into five groups as Control, L-NAME 25 mgkg, HES 100 mgkg, L-NAME-HES and L-NAME P-HES. After the 13th day of pregnancy, the chemicals were administrated until the 20th day. 20 days after the offsprings birth, they were separated from their mothers and all rats were sacrificed after 6 weeks time. Serum samples were analyzed for levels of Glutathione GSH, lipid peroxidation LPO, and neuron-specific enolase NSE activity. Urine samples were analyzed for the pro-teinuria. While Proteinuria and LPO level increasing, GSH levels decreased in the L-NAME group when compared to the Control. As we compared L-NAME group with the L-NAME-HES and L-NAME P-HES groups, the GSH levels increased significantly while LPO levels in the HES, L-NAME-HES, L-NAME P-HES groups were decreasing. The NSE activity signifi-cantly increased in the L-NAME group compared to the Control. In contrast to the L-NAME group, its activity decreased in HES, L-NAME-HES and L-NAME P-HES groups significantly. Briefly, it can be said that HES has a significant effect on both the LPO levels and the NSE activity in the case of pre-eclampsia.

 This study evaluates the protective effect of Hesperidin HES, flavanoglycone, during pre-ec-lampsia developed pregnancy. The pregnant rats were randomly divided into five groups as Control, L-NAME 25 mgkg, HES 100 mgkg, L-NAME-HES and L-NAME P-HES. After the 13th day of pregnancy, the chemicals were administrated until the 20th day. 20 days after the offsprings birth, they were separated from their mothers and all rats were sacrificed after 6 weeks time. Serum samples were analyzed for levels of Glutathione GSH, lipid peroxidation LPO, and neuron-specific enolase NSE activity. Urine samples were analyzed for the pro-teinuria. While Proteinuria and LPO level increasing, GSH levels decreased in the L-NAME group when compared to the Control. As we compared L-NAME group with the L-NAME-HES and L-NAME P-HES groups, the GSH levels increased significantly while LPO levels in the HES, L-NAME-HES, L-NAME P-HES groups were decreasing. The NSE activity signifi-cantly increased in the L-NAME group compared to the Control. In contrast to the L-NAME group, its activity decreased in HES, L-NAME-HES and L-NAME P-HES groups significantly. Briefly, it can be said that HES has a significant effect on both the LPO levels and the NSE activity in the case of pre-eclampsia.

 This study evaluates the protective effect of Hesperidin HES, flavanoglycone, during pre-ec-lampsia developed pregnancy. The pregnant rats were randomly divided into five groups as Control, L-NAME 25 mgkg, HES 100 mgkg, L-NAME-HES and L-NAME P-HES. After the 13th day of pregnancy, the chemicals were administrated until the 20th day. 20 days after the offsprings birth, they were separated from their mothers and all rats were sacrificed after 6 weeks time. Serum samples were analyzed for levels of Glutathione GSH, lipid peroxidation LPO, and neuron-specific enolase NSE activity. Urine samples were analyzed for the pro-teinuria. While Proteinuria and LPO level increasing, GSH levels decreased in the L-NAME group when compared to the Control. As we compared L-NAME group with the L-NAME-HES and L-NAME P-HES groups, the GSH levels increased significantly while LPO levels in the HES, L-NAME-HES, L-NAME P-HES groups were decreasing. The NSE activity signifi-cantly increased in the L-NAME group compared to the Control. In contrast to the L-NAME group, its activity decreased in HES, L-NAME-HES and L-NAME P-HES groups significantly. Briefly, it can be said that HES has a significant effect on both the LPO levels and the NSE activity in the case of pre-eclampsia.

Makale detayları

The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model

Yazarlar:

N.A.

Yayıncı:

Yildiz Technical University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Sigma Journal of Engineering and Natural Sciences Vol.42 Issue 2, pp.497-502

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316871

pISSN:

1304-7191

Hesperidin

Pre-Eclampsia

Oxidative Damage

Neuron- Spesific Enolase

Sayı

Makale detayları

The effect of hesperidin on neuron-specific enolase and oxidative damage in the pre-eclampsia model

Yazarlar: N.A.

Yayıncı: Yildiz Technical University

Ana Başlıklar: Clinical Sciences (Other)

Dergi: Sigma Journal of Engineering and Natural Sciences Vol.42 Issue 2, pp.497-502

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001316871

pISSN: 1304-7191

Hesperidin

Pre-Eclampsia

Oxidative Damage

Neuron- Spesific Enolase

Sayı

Yazarlar:

N.A.

Yayıncı:

Yildiz Technical University

Ana Başlıklar:

Clinical Sciences (Other)

Dergi:

Sigma Journal of Engineering and Natural Sciences Vol.42 Issue 2, pp.497-502

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001316871

pISSN:

1304-7191