The Effect of Nebivolol on Acute Brain Damage in a Rat Model of Lps-Induced Inflammation

Ali Serdar Oğuzoğlu; Nilgün Şenol; Duygu Doguc; Şerife Taşan; Yalçın Erzurumlu; Halil Aşcı

Makale detayları

The Effect of Nebivolol on Acute Brain Damage in a Rat Model of Lps-Induced Inflammation

Yazarlar:

Ali Serdar Oğuzoğlu | Nilgün Şenol | Duygu Doguc | Şerife Taşan | Yalçın Erzurumlu | Halil Aşcı

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Brain and Nerve Surgery (Neurosurgery)

Dergi:

Medical Journal of Süleyman Demirel University Vol.32 Issue 1, pp.27-35

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344157

pISSN:

1300-7416

Anahtar kelimeler:

Özet:

 Objective: This research seeks to determine whether nebivolol NEB can prevent brain damage caused by lipopolysaccharide LPS. Material and method: The thirty-two female Wistar Albino rats were divided into four groups, each containing eight rats: LPS 5mgkg single dose i.p., Control, LPSNEB, and NEB 1 ml of 10 kg mgkg given by oral gavage every day for three days. In brain tissues, the following parameters were measured: tumor necrosis factor-alpha TNF-α, vascular endothelial growth factor A VEGFA, caspase-3 Cas-3, total antioxidant status TAS, total oxidant status TOS, and oxidative stress index OSI. Results: In the LPS group, there was an increase in the levels of TOS, VEGFA, Cas-3, and TNF-α. NEB therapy markedly reduced TOS, VEGFA, TNF-α, and Cas-3 levels. In both the control and NEB groups, histopathological analysis of the brain, hippocampus, and cerebellum demonstrated normal tissue architecture. In the LPS group, there were mild to moderate hemorrhages and severe hyperemia in the meningeal and parenchymal arteries of the brain and cerebellum. The LPS  NEB groups histopathology results were significantly ameliorated by NEB treatment. Conclusion: NEB treatments anti-inflammatory, anti-apoptotic, and antioxidant characteristics helped mitigate the brain damage caused by LPS. NEB may help to reduce the severity of LPS-induced damage.

 Objective: This research seeks to determine whether nebivolol NEB can prevent brain damage caused by lipopolysaccharide LPS. Material and method: The thirty-two female Wistar Albino rats were divided into four groups, each containing eight rats: LPS 5mgkg single dose i.p., Control, LPSNEB, and NEB 1 ml of 10 kg mgkg given by oral gavage every day for three days. In brain tissues, the following parameters were measured: tumor necrosis factor-alpha TNF-α, vascular endothelial growth factor A VEGFA, caspase-3 Cas-3, total antioxidant status TAS, total oxidant status TOS, and oxidative stress index OSI. Results: In the LPS group, there was an increase in the levels of TOS, VEGFA, Cas-3, and TNF-α. NEB therapy markedly reduced TOS, VEGFA, TNF-α, and Cas-3 levels. In both the control and NEB groups, histopathological analysis of the brain, hippocampus, and cerebellum demonstrated normal tissue architecture. In the LPS group, there were mild to moderate hemorrhages and severe hyperemia in the meningeal and parenchymal arteries of the brain and cerebellum. The LPS  NEB groups histopathology results were significantly ameliorated by NEB treatment. Conclusion: NEB treatments anti-inflammatory, anti-apoptotic, and antioxidant characteristics helped mitigate the brain damage caused by LPS. NEB may help to reduce the severity of LPS-induced damage.

 Objective: This research seeks to determine whether nebivolol NEB can prevent brain damage caused by lipopolysaccharide LPS. Material and method: The thirty-two female Wistar Albino rats were divided into four groups, each containing eight rats: LPS 5mgkg single dose i.p., Control, LPSNEB, and NEB 1 ml of 10 kg mgkg given by oral gavage every day for three days. In brain tissues, the following parameters were measured: tumor necrosis factor-alpha TNF-α, vascular endothelial growth factor A VEGFA, caspase-3 Cas-3, total antioxidant status TAS, total oxidant status TOS, and oxidative stress index OSI. Results: In the LPS group, there was an increase in the levels of TOS, VEGFA, Cas-3, and TNF-α. NEB therapy markedly reduced TOS, VEGFA, TNF-α, and Cas-3 levels. In both the control and NEB groups, histopathological analysis of the brain, hippocampus, and cerebellum demonstrated normal tissue architecture. In the LPS group, there were mild to moderate hemorrhages and severe hyperemia in the meningeal and parenchymal arteries of the brain and cerebellum. The LPS  NEB groups histopathology results were significantly ameliorated by NEB treatment. Conclusion: NEB treatments anti-inflammatory, anti-apoptotic, and antioxidant characteristics helped mitigate the brain damage caused by LPS. NEB may help to reduce the severity of LPS-induced damage.

 Objective: This research seeks to determine whether nebivolol NEB can prevent brain damage caused by lipopolysaccharide LPS. Material and method: The thirty-two female Wistar Albino rats were divided into four groups, each containing eight rats: LPS 5mgkg single dose i.p., Control, LPSNEB, and NEB 1 ml of 10 kg mgkg given by oral gavage every day for three days. In brain tissues, the following parameters were measured: tumor necrosis factor-alpha TNF-α, vascular endothelial growth factor A VEGFA, caspase-3 Cas-3, total antioxidant status TAS, total oxidant status TOS, and oxidative stress index OSI. Results: In the LPS group, there was an increase in the levels of TOS, VEGFA, Cas-3, and TNF-α. NEB therapy markedly reduced TOS, VEGFA, TNF-α, and Cas-3 levels. In both the control and NEB groups, histopathological analysis of the brain, hippocampus, and cerebellum demonstrated normal tissue architecture. In the LPS group, there were mild to moderate hemorrhages and severe hyperemia in the meningeal and parenchymal arteries of the brain and cerebellum. The LPS  NEB groups histopathology results were significantly ameliorated by NEB treatment. Conclusion: NEB treatments anti-inflammatory, anti-apoptotic, and antioxidant characteristics helped mitigate the brain damage caused by LPS. NEB may help to reduce the severity of LPS-induced damage.

Makale detayları

The Effect of Nebivolol on Acute Brain Damage in a Rat Model of Lps-Induced Inflammation

Yazarlar:

Ali Serdar Oğuzoğlu | Nilgün Şenol | Duygu Doguc | Şerife Taşan | Yalçın Erzurumlu | Halil Aşcı

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Brain and Nerve Surgery (Neurosurgery)

Dergi:

Medical Journal of Süleyman Demirel University Vol.32 Issue 1, pp.27-35

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344157

pISSN:

1300-7416

LPS

Brain

Nebivolol

oxidative stress

inflammation

apoptosis

Sayı

Makale detayları

The Effect of Nebivolol on Acute Brain Damage in a Rat Model of Lps-Induced Inflammation

Yazarlar: Ali Serdar Oğuzoğlu | Nilgün Şenol | Duygu Doguc | Şerife Taşan | Yalçın Erzurumlu | Halil Aşcı

Yayıncı: Süleyman Demirel University

Ana Başlıklar: Brain and Nerve Surgery (Neurosurgery)

Dergi: Medical Journal of Süleyman Demirel University Vol.32 Issue 1, pp.27-35

Belge Tipi: Makale

Yayın Tarihi: 3/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001344157

pISSN: 1300-7416

LPS

Brain

Nebivolol

oxidative stress

inflammation

apoptosis

Sayı

Yazarlar:

Ali Serdar Oğuzoğlu | Nilgün Şenol | Duygu Doguc | Şerife Taşan | Yalçın Erzurumlu | Halil Aşcı

Yayıncı:

Süleyman Demirel University

Ana Başlıklar:

Brain and Nerve Surgery (Neurosurgery)

Dergi:

Medical Journal of Süleyman Demirel University Vol.32 Issue 1, pp.27-35

Belge Tipi:

Makale

Yayın Tarihi:

3/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001344157

pISSN:

1300-7416