INFLAMMATION IN NEWLY DIAGNOSED DIABETES PATIENTS

Orkun Sarıçam

Makale detayları

INFLAMMATION IN NEWLY DIAGNOSED DIABETES PATIENTS

Yazarlar:

Orkun Sarıçam

Yayıncı:

Kocaeli University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Acta Medica Nicomedia Vol.6 Issue 1, pp.143-147

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284606

pISSN:

2717-8994

Anahtar kelimeler:

Özet:

 Objective. Type 2 diabetes mellitus T2DM is a chronic disease with an increasing prevalence, accounting for 90-95 of all diabetics. It is considered that the disease is induced by inflammation. In this study, we aimed to investigate the inflammation parameters and the relationship of these parameters with blood groups in newly diagnosed T2DM patients. Methods. The study included 80 newly diagnosed T2DM patients and 80 healthy volunteers. Demographic characteristics, body mass indexes BMI, biochemistry and hemogram test results, C-reactive protein CRP values, and blood groups of the patient and control groups were recorded and compared between the groups. Results. The mean age was 51.64 years and 53.8 of the patients were male in the newly diagnosed T2DM group. The counts of white blood cells WBC, neutrophils, lymphocytes, platelets, and monocytes, the values of the monocyteHDL ratio MHR and the systemic immune-inflammatory index SII, and the CRP levels of T2DM patients were statistically significantly higher than those of the control group p0.05. Of the T2DM patients, the platelet counts were statistically significantly higher in the blood type B group compared to the blood type O group p0.022. Conclusion. We think that the hematological parameters of inflammation and the high MHR and SII ratios indicate the presence of chronic systemic inflammation in newly diagnosed T2DM patients before the development of complications. Therefore, these parameters may guide the diagnosis and preventive treatment in prediabetic patients.

 Objective. Type 2 diabetes mellitus T2DM is a chronic disease with an increasing prevalence, accounting for 90-95 of all diabetics. It is considered that the disease is induced by inflammation. In this study, we aimed to investigate the inflammation parameters and the relationship of these parameters with blood groups in newly diagnosed T2DM patients. Methods. The study included 80 newly diagnosed T2DM patients and 80 healthy volunteers. Demographic characteristics, body mass indexes BMI, biochemistry and hemogram test results, C-reactive protein CRP values, and blood groups of the patient and control groups were recorded and compared between the groups. Results. The mean age was 51.64 years and 53.8 of the patients were male in the newly diagnosed T2DM group. The counts of white blood cells WBC, neutrophils, lymphocytes, platelets, and monocytes, the values of the monocyteHDL ratio MHR and the systemic immune-inflammatory index SII, and the CRP levels of T2DM patients were statistically significantly higher than those of the control group p0.05. Of the T2DM patients, the platelet counts were statistically significantly higher in the blood type B group compared to the blood type O group p0.022. Conclusion. We think that the hematological parameters of inflammation and the high MHR and SII ratios indicate the presence of chronic systemic inflammation in newly diagnosed T2DM patients before the development of complications. Therefore, these parameters may guide the diagnosis and preventive treatment in prediabetic patients.

 Objective. Type 2 diabetes mellitus T2DM is a chronic disease with an increasing prevalence, accounting for 90-95 of all diabetics. It is considered that the disease is induced by inflammation. In this study, we aimed to investigate the inflammation parameters and the relationship of these parameters with blood groups in newly diagnosed T2DM patients. Methods. The study included 80 newly diagnosed T2DM patients and 80 healthy volunteers. Demographic characteristics, body mass indexes BMI, biochemistry and hemogram test results, C-reactive protein CRP values, and blood groups of the patient and control groups were recorded and compared between the groups. Results. The mean age was 51.64 years and 53.8 of the patients were male in the newly diagnosed T2DM group. The counts of white blood cells WBC, neutrophils, lymphocytes, platelets, and monocytes, the values of the monocyteHDL ratio MHR and the systemic immune-inflammatory index SII, and the CRP levels of T2DM patients were statistically significantly higher than those of the control group p0.05. Of the T2DM patients, the platelet counts were statistically significantly higher in the blood type B group compared to the blood type O group p0.022. Conclusion. We think that the hematological parameters of inflammation and the high MHR and SII ratios indicate the presence of chronic systemic inflammation in newly diagnosed T2DM patients before the development of complications. Therefore, these parameters may guide the diagnosis and preventive treatment in prediabetic patients.

 Amaç: Tip 2 diyabetes mellutus T2DM, inflamasyonun indüklediği düşünülen, tüm diyabetlilerin 90-95ini oluşturan prevelansı giderek artan kronik bir hastalıktır. Bu çalışmada yeni tanı almış T2DM olan hastalarda inflamasyon parametrelerini ve bu parametrelerin kan grupları ile ilişkisini araştırmayı amaçladık. Yöntem: Bu çalışmaya 80 yeni tanı almış T2DM hastası, 80 sağlıklı gönüllü dahil edildi. Hasta ve kontrol grubunun demografik özellikleri, vücut kitle indeksleri VKİ, biyokimya, hemogram, C-reaktif proteini CRP ve kan grupları kayıt edilerek gruplar arasında karşılaştırıldı. Bulgular: Yeni tanı alan T2DM hastalarının yaş ortalaması 51,64dü ve hastaların 53,8i erkekti. T2DM hastaların beyaz kan hücresi BKH, nötrofil, lenfosit, platelet, monosit, monositHDL oranı MHO, sistemik immün-inflamatuar indeks Sİİ ve CRP düzeyleri kontrol grubundan istatistiksel olarak anlamlı derecede yüksek saptandı. p0,05 T2DMli hastalarda kan grubu B olanların platelet değerleri, kan grubu O olan grupdan istatistiksel olarak anlamlı derecede yüksek saptandı. p0,022 Sonuç: Yeni tanı T2DM hastalarında inflmasyonu gösteren hematolojik parametrelerin ve MHO ve Sİİ oranlarındaki yüksekliğinin, hastalarda komplikasyon gelişmeden kronik sistemik enflamasyonun varlığını gösterdiğini, prediyabetik hastalarda tanıda ve koruyucu tedaviye başlamada yol gösterici olabileceğini düşünüyoruz.

Makale detayları

INFLAMMATION IN NEWLY DIAGNOSED DIABETES PATIENTS

Yazarlar:

Orkun Sarıçam

Yayıncı:

Kocaeli University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Acta Medica Nicomedia Vol.6 Issue 1, pp.143-147

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284606

pISSN:

2717-8994

Type 2 diabetes mellitus

inflammation

blood group.

Tip 2 diyabetes mellutus

inflamasyon

kan grubu

Sayı

Makale detayları

INFLAMMATION IN NEWLY DIAGNOSED DIABETES PATIENTS

Yazarlar: Orkun Sarıçam

Yayıncı: Kocaeli University

Ana Başlıklar: Klinik Tıp Bilimleri

Dergi: Acta Medica Nicomedia Vol.6 Issue 1, pp.143-147

Belge Tipi: Makale

Yayın Tarihi: 2/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001284606

pISSN: 2717-8994

Type 2 diabetes mellitus

inflammation

blood group.

Tip 2 diyabetes mellutus

inflamasyon

kan grubu

Sayı

Yazarlar:

Orkun Sarıçam

Yayıncı:

Kocaeli University

Ana Başlıklar:

Klinik Tıp Bilimleri

Dergi:

Acta Medica Nicomedia Vol.6 Issue 1, pp.143-147

Belge Tipi:

Makale

Yayın Tarihi:

2/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001284606

pISSN:

2717-8994