Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design

N.A.

Makale detayları

Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.179-195

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347810

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 Dapsone is a class II BCS with antibacterial and anti-inflammatory action. The goal of this study was to devise a dapsone DP system of solid self-microemulsifying drug delivery S-SMEDDS. Various proportions of capryol 90 as an oil form, tween 80 as a surfactant and Labrasol as a co-surfactant were selected to prepare a pseudo ternary diagram for the self-microemulsifying drug delivery system L-SMEDDS. The optimized formulation of L- SMEDDS F8 containing capryol 90 10 percent ww, Tween 80 67.55 ww, and labrasol 22.5 percent ww showed the smallest particle size, less emulsification time, high optical clarity, in-vitro release and improved ex-vivo permeation. L-SMEDDDS was converted to S-SMEDDS by adsorbing on neusilin US2 and spray drying with aerosil 200. The effect of inlet temperature A, feed flow rate B and carrier concentration C on particle size Y1 and  practical yield Y2 was studied using Box-Behnken design. Using the results of dependent variables, polynomial equations, surface response plots, and contour plots were developed. S-SMEDDS have been tested for flow properties, drug quality, reconstitution properties, DSC, XRD, SEM, drug release in vitro and anti-inflammatory activity in vivo. The present study showed the applicability of design of experiments DOE to optimize the process parameters needed to produce DP S-SMEDDS as an effective approach to improving its solubility.

 Dapsone is a class II BCS with antibacterial and anti-inflammatory action. The goal of this study was to devise a dapsone DP system of solid self-microemulsifying drug delivery S-SMEDDS. Various proportions of capryol 90 as an oil form, tween 80 as a surfactant and Labrasol as a co-surfactant were selected to prepare a pseudo ternary diagram for the self-microemulsifying drug delivery system L-SMEDDS. The optimized formulation of L- SMEDDS F8 containing capryol 90 10 percent ww, Tween 80 67.55 ww, and labrasol 22.5 percent ww showed the smallest particle size, less emulsification time, high optical clarity, in-vitro release and improved ex-vivo permeation. L-SMEDDDS was converted to S-SMEDDS by adsorbing on neusilin US2 and spray drying with aerosil 200. The effect of inlet temperature A, feed flow rate B and carrier concentration C on particle size Y1 and  practical yield Y2 was studied using Box-Behnken design. Using the results of dependent variables, polynomial equations, surface response plots, and contour plots were developed. S-SMEDDS have been tested for flow properties, drug quality, reconstitution properties, DSC, XRD, SEM, drug release in vitro and anti-inflammatory activity in vivo. The present study showed the applicability of design of experiments DOE to optimize the process parameters needed to produce DP S-SMEDDS as an effective approach to improving its solubility.

 Dapsone is a class II BCS with antibacterial and anti-inflammatory action. The goal of this study was to devise a dapsone DP system of solid self-microemulsifying drug delivery S-SMEDDS. Various proportions of capryol 90 as an oil form, tween 80 as a surfactant and Labrasol as a co-surfactant were selected to prepare a pseudo ternary diagram for the self-microemulsifying drug delivery system L-SMEDDS. The optimized formulation of L- SMEDDS F8 containing capryol 90 10 percent ww, Tween 80 67.55 ww, and labrasol 22.5 percent ww showed the smallest particle size, less emulsification time, high optical clarity, in-vitro release and improved ex-vivo permeation. L-SMEDDDS was converted to S-SMEDDS by adsorbing on neusilin US2 and spray drying with aerosil 200. The effect of inlet temperature A, feed flow rate B and carrier concentration C on particle size Y1 and  practical yield Y2 was studied using Box-Behnken design. Using the results of dependent variables, polynomial equations, surface response plots, and contour plots were developed. S-SMEDDS have been tested for flow properties, drug quality, reconstitution properties, DSC, XRD, SEM, drug release in vitro and anti-inflammatory activity in vivo. The present study showed the applicability of design of experiments DOE to optimize the process parameters needed to produce DP S-SMEDDS as an effective approach to improving its solubility.

 Dapsone is a class II BCS with antibacterial and anti-inflammatory action. The goal of this study was to devise a dapsone DP system of solid self-microemulsifying drug delivery S-SMEDDS. Various proportions of capryol 90 as an oil form, tween 80 as a surfactant and Labrasol as a co-surfactant were selected to prepare a pseudo ternary diagram for the self-microemulsifying drug delivery system L-SMEDDS. The optimized formulation of L- SMEDDS F8 containing capryol 90 10 percent ww, Tween 80 67.55 ww, and labrasol 22.5 percent ww showed the smallest particle size, less emulsification time, high optical clarity, in-vitro release and improved ex-vivo permeation. L-SMEDDDS was converted to S-SMEDDS by adsorbing on neusilin US2 and spray drying with aerosil 200. The effect of inlet temperature A, feed flow rate B and carrier concentration C on particle size Y1 and  practical yield Y2 was studied using Box-Behnken design. Using the results of dependent variables, polynomial equations, surface response plots, and contour plots were developed. S-SMEDDS have been tested for flow properties, drug quality, reconstitution properties, DSC, XRD, SEM, drug release in vitro and anti-inflammatory activity in vivo. The present study showed the applicability of design of experiments DOE to optimize the process parameters needed to produce DP S-SMEDDS as an effective approach to improving its solubility.

Makale detayları

Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.179-195

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347810

pISSN:

2630-6344

Self micro-emulsifying drug delivery system

labrasol

capryol 90

Box-Behnken design

neusilin US2.

Sayı

Makale detayları

Conceptual design and optimization of self microemulsifying drug delivery systems for dapsone by using Box-Behnken design

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmaceutical Delivery Technologies

Dergi: Journal of Research in Pharmacy Vol.25 Issue 2, pp.179-195

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001347810

pISSN: 2630-6344

Self micro-emulsifying drug delivery system

labrasol

capryol 90

Box-Behnken design

neusilin US2.

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmaceutical Delivery Technologies

Dergi:

Journal of Research in Pharmacy Vol.25 Issue 2, pp.179-195

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001347810

pISSN:

2630-6344