Irak-4 rs4251481 gene variant: as a risk factor on inflammatory bowel disease

Gonca CANDAN; Resul KAHRAMAN; Hayriye Arzu ERGEN

Makale detayları

Irak-4 rs4251481 gene variant: as a risk factor on inflammatory bowel disease

Yazarlar:

Gonca CANDAN | Resul KAHRAMAN | Hayriye Arzu ERGEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.478-482

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750162

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Özet:

 

Background/aim:  Abnormal  immune  response  occurs  in  individuals  who  have  alleles  associated  with  innate  and  adaptive  immune  mechanisms  that  predispose  to  inflammatory  bowel  disease  (IBD).  Interleukin-1  receptor-associated  kinase  4  (IRAK-4)  involved  in  the pathway produces cytokines that initiate and maintain inflammation through Toll-like receptors and interleukin-1 receptors on the membranes of innate immune cells are stimulated with antigens. It was aimed to investigate whether IRAK-4 rs3794262 and rs4251481 polymorphisms predispose to IBD and the possible effects of these polymorphisms by examining these gene polymorphisms with the clinic and prognostic parameters of IBD.Material and methods: Real-time PCR technique was used to detect IRAK-4 polymorphisms in 107 patients with IBD and 103 healthy controls. Results: As a result of experimental studies, the frequency of occurrence of rs4251481 polymorphism related AG genotype (P = 0.029) and G allele (P = 0.005) was found to increase statistically in patients compared to controls. In the control group, the rs4251481 AA genotype rate of incidence increased compared with the patient group (P = 0.005).Conclusion:  Consequently,  this  is  the  first  study  in  terms  of  both  polymorphisms  on  IBD.  These  results  suggest  that  rs4251481  AG  genotype and G allele are associated with increased IBD risk in patients.

Makale detayları

Irak-4 rs4251481 gene variant: as a risk factor on inflammatory bowel disease

Yazarlar: Gonca CANDAN | Resul KAHRAMAN | Hayriye Arzu ERGEN

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.478-482

Belge Tipi: Makale

Yayın Tarihi: 3/2019

Belge Dili: Türkçe

Document ID (Org No.): 2000750162

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Sayı

Yazarlar:

Gonca CANDAN | Resul KAHRAMAN | Hayriye Arzu ERGEN

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2019 Vol.49 Issue 2, pp.478-482

Belge Tipi:

Makale

Yayın Tarihi:

3/2019

Belge Dili:

Türkçe

Document ID (Org No.):

2000750162

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144