Clinical evaluation of topical tacrolimus ointment usage in different stages of keratoconjunctivitis sicca in dogs

Christina JOHN; Aswathy GOPINATHAN; Kiranjeet SINGH; Pallvi SHARMA; Chelladurai SOWBHARENYA; Sherin B. SARANGOM

Makale detayları

Clinical evaluation of topical tacrolimus ointment usage in different stages of keratoconjunctivitis sicca in dogs

Yazarlar:

Christina JOHN | Aswathy GOPINATHAN | Kiranjeet SINGH | Pallvi SHARMA | Chelladurai SOWBHARENYA | Sherin B. SARANGOM

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2018 Vol.42 Issue 4, pp.259-268

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000764575

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128

Özet:

 

This  study  was  conducted  to  investigate  the  effect  of  topical  tacrolimus  (0.1%)  ointment  in  stimulating  tear  production  in  
dogs with keratoconjunctivitis sicca (KCS). Thirty-six dogs (58 eyes) diagnosed with KCS were included in this study. KCS was grouped 
as  early  (E,  n  =  21  eyes),  late  (L,  n  =  21  eyes),  and  reflex  tear  due  to  corneal  ulceration  (R,  n  =  16  eyes)  based  on  Schirmer  tear  test  
(STT)  readings.  The  dogs  in  each  group  were  randomly  allotted  treatment  with  either  tacrolimus  0.1%  ointment  applied  once  daily  
(ET,  n  =  11  eyes;  LT,  n  =  10  eyes;  RT,  n  =  6  eyes)  or  cyclosporine  (CsA)  0.05%  eye  drops  instilled  five  times  daily  (EC,  n  =  10  eyes;  
LC,  n  =  11  eyes;  RC,  n  =  10  eyes)  for  2  months.  The  efficacy  of  the  treatments  was  evaluated  and  comparison  was  made  based  on  
complete  ophthalmic  examination  and  a  scoring  system  for  various  parameters  like  menace  reflex,  palpebral  reflex,  pupillary  light  
reflex, conjunctival hyperemia, ocular discharge, corneal clarity, corneal ulceration, corneal vessel length, corneal vessel density, corneal 
pigmentation area, corneal pigmentation density, STT readings, fluorescein dye test, and Rose Bengal dye test. The effect of treatment 
was evaluated on day 15, 30, and 60 after treatments. Good quality digital photographs from a fixed distance were taken at each interval 
to aid subjective evaluation. Data were analyzed using one-way and repeated-measures ANOVA followed by Tukey?s HSD test, Wilcoxon 
signed rank test, and Kruskal?Wallis test followed by Dunn?s test to identify significant interactions. The level of significance was set 
to P < 0.05. Improvement in menace reflex and pupillary light reflex was observed in both treatment groups. Conjunctival hyperemia 
and ocular discharge decreased significantly after treatment with both of the drugs. There was no significant difference in improvement 
in  tear  production  between  treatment  groups  but  tacrolimus  0.1%  ointment  significantly  arrested  the  progression  of  pigments.  The  
study concluded that both tacrolimus 0.1% ointment and CsA 0.05% eye drops improve tear production in KCS-affected dogs. Topical 
tacrolimus 0.1% ointment effectively arrests the progression of pigmentation compared to CsA 0.05% eye drops in KCS-affected dogs.

Makale detayları

Clinical evaluation of topical tacrolimus ointment usage in different stages of keratoconjunctivitis sicca in dogs

Yazarlar: Christina JOHN | Aswathy GOPINATHAN | Kiranjeet SINGH | Pallvi SHARMA | Chelladurai SOWBHARENYA | Sherin B. SARANGOM

Yayıncı: TUBITAK

Dergi: Turkish Journal of Veterinary and Animal Sciences 2018 Vol.42 Issue 4, pp.259-268

Belge Tipi: Makale

Yayın Tarihi: 8/2018

Belge Dili: İngilizce

Document ID (Org No.): 2000764575

Sıklık: İki Aylık

eISSN: 1303-6181

pISSN: 1300-0128

Sayı

Yazarlar:

Christina JOHN | Aswathy GOPINATHAN | Kiranjeet SINGH | Pallvi SHARMA | Chelladurai SOWBHARENYA | Sherin B. SARANGOM

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Veterinary and Animal Sciences 2018 Vol.42 Issue 4, pp.259-268

Belge Tipi:

Makale

Yayın Tarihi:

8/2018

Belge Dili:

İngilizce

Document ID (Org No.):

2000764575

Sıklık:

İki Aylık

eISSN:

1303-6181

pISSN:

1300-0128