Evaluation of MMP2, Caspase-3 and C-Kit Expression on Thyroid Papillary Cancer Prognosis

Arzu BOZTAŞ; Hakan BULUŞ; Gülçin GÜLER ŞİMŞEK; Altan AYDIN; Arzu KOÇDOĞAN; Volkan ATEŞ; Serpil OĞUZTÜZÜN

doi:https://doi.org/10.47947/ijnls.915634

Makale detayları

Evaluation of MMP2, Caspase-3 and C-Kit Expression on Thyroid Papillary Cancer Prognosis

Yazarlar:

Arzu BOZTAŞ | Hakan BULUŞ | Gülçin GÜLER ŞİMŞEK | Altan AYDIN | Arzu KOÇDOĞAN | Volkan ATEŞ | Serpil OĞUZTÜZÜN

Yayıncı:

Uğur ÇAKILCIOĞLU

Ana Başlıklar:

Yaşam bilimleri

Dergi:

International Journal of Nature and Life Sciences 2021 Vol.5 Issue 1, pp.23-32

Belge Tipi:

Makale

Yayın Tarihi:

5/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000468510

Sıklık:

İki Yıllık

eISSN:

2602-2397

pISSN:

2602-2478

DOI:

https://doi.org/10.47947/ijnls.915634

Özet:

 

A number of new molecular and genetic factors are currently being studied in determining the prognosis of thyroid papillary carcinoma. In our study, we aimed to determine if there was a relationship between prognostic factors and expression of Matrixmatalloproteniase 2 (MMP-2), the tyrosine-kinase receptor CD117 (c-kit) and caspase-3. MMP2, c-kit and caspase-3 by immunohistochemical (IHC) method were studied in both intact and pathological tissue of the thyroid gland removed after surgery in patients with thyroid papillary cancer. Prognostic factors such as age, histological stage, extrathyroidal spread, metastasis, tumor size were also evaluated. There was no statistically significant difference between prognosis and c-kit, MMP-2 and caspase-3 expression in patients (p>0.05). Clinicopathological parameters were thought to be more important than c-kit, caspase 3 and MMP2 in predicting prognosis in thyroid papillary cancers.

Makale detayları

Evaluation of MMP2, Caspase-3 and C-Kit Expression on Thyroid Papillary Cancer Prognosis

Yazarlar: Arzu BOZTAŞ | Hakan BULUŞ | Gülçin GÜLER ŞİMŞEK | Altan AYDIN | Arzu KOÇDOĞAN | Volkan ATEŞ | Serpil OĞUZTÜZÜN

Yayıncı: Uğur ÇAKILCIOĞLU

Ana Başlıklar: Yaşam bilimleri

Dergi: International Journal of Nature and Life Sciences 2021 Vol.5 Issue 1, pp.23-32

Belge Tipi: Makale

Yayın Tarihi: 5/2021

Belge Dili: İngilizce

Document ID (Org No.): 2000468510

Sıklık: İki Yıllık

eISSN: 2602-2397

pISSN: 2602-2478

DOI: https://doi.org/10.47947/ijnls.915634

Sayı

Yazarlar:

Arzu BOZTAŞ | Hakan BULUŞ | Gülçin GÜLER ŞİMŞEK | Altan AYDIN | Arzu KOÇDOĞAN | Volkan ATEŞ | Serpil OĞUZTÜZÜN

Yayıncı:

Uğur ÇAKILCIOĞLU

Ana Başlıklar:

Yaşam bilimleri

Dergi:

International Journal of Nature and Life Sciences 2021 Vol.5 Issue 1, pp.23-32

Belge Tipi:

Makale

Yayın Tarihi:

5/2021

Belge Dili:

İngilizce

Document ID (Org No.):

2000468510

Sıklık:

İki Yıllık

eISSN:

2602-2397

pISSN:

2602-2478

DOI:

https://doi.org/10.47947/ijnls.915634