Clinical Evaluation of System Involvement of Children with Henoch-Schönlein Purpura Introduction

Dilek Borakay; Özgül Yiğit

Makale detayları

Clinical Evaluation of System Involvement of Children with Henoch-Schönlein Purpura Introduction

Yazarlar:

Dilek Borakay | Özgül Yiğit

Yayıncı:

Kocaeli University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Acta Medica Nicomedia Vol.7 Issue 3, pp.252-256

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001330568

pISSN:

2717-8994

Anahtar kelimeler:

Özet:

 Background-Aim: Henoch-Schönlein purpuraImmunoglobulin A vasculitis HSPIgAV, is common vasculitis in childhood, and some infections, drugs, vaccines, genetics and familial Mediterranean fever FMF have been shown in its etiology. Skin palpable purpura, joints, and many other systems are affected. While gastrointestinal complications are seen initially, kidney involvement, which can progress to kidney failure, gains importance in later periods. This study aimed to evaluate the demographic characteristics of the children with HSPIgAV, the distribution of system involvement, etiological factors, and their relationship with FMF. Patients and Method: Purpura and one of the following four other criteria, abdominal pain, arthritisarthralgia, renal involvement, and demonstration of IgA storage in the biopsy, were accepted as diagnostic criteria. The age, sex, body weight, height, date of onset of the disease, first symptom, physical examination, and laboratory findings of children diagnosed with HSPIgAV were recorded. Results: A total of 52 patients who met the diagnostic criteria were included in the study. The average age was 7.53.6 4-13 and 40 of the cases were between 7-10 years old. Distribution by sex was 32 boys 61.5, 20 girls 38.4, and the boygirl ratio was 1.6. When the distribution of the year was analyzed, it was found that the number of patients was concentrated 46.15; n24 in winter, especially in December. The first complaint was rash at the rate of 80.7 n42. In others, the rash appeared to occur after edema and arthralgia. Joint involvement in 21 40.3, gastrointestinal involvement in 21 40.3, abnormal urine findings in 21 40.3, high serum IgA in 13 25, and 10 19.2 FMF association was detected. Viral investigations in etiology were positive in 6 cases 12. In the follow-up, urine findings were continuing in 6 cases 11.5 after 3 months. Renal involvement was concentrated in girls, ages 3-6 and over 10 years of age. Conclusion: Since the prognosis depends on renal involvement in the evaluation of HSPIgAV cases, it is important to carry out urine tests during the disease and especially during long-term follow-up, and also to consider FMF association which is common in our country.

 Background-Aim: Henoch-Schönlein purpuraImmunoglobulin A vasculitis HSPIgAV, is common vasculitis in childhood, and some infections, drugs, vaccines, genetics and familial Mediterranean fever FMF have been shown in its etiology. Skin palpable purpura, joints, and many other systems are affected. While gastrointestinal complications are seen initially, kidney involvement, which can progress to kidney failure, gains importance in later periods. This study aimed to evaluate the demographic characteristics of the children with HSPIgAV, the distribution of system involvement, etiological factors, and their relationship with FMF. Patients and Method: Purpura and one of the following four other criteria, abdominal pain, arthritisarthralgia, renal involvement, and demonstration of IgA storage in the biopsy, were accepted as diagnostic criteria. The age, sex, body weight, height, date of onset of the disease, first symptom, physical examination, and laboratory findings of children diagnosed with HSPIgAV were recorded. Results: A total of 52 patients who met the diagnostic criteria were included in the study. The average age was 7.53.6 4-13 and 40 of the cases were between 7-10 years old. Distribution by sex was 32 boys 61.5, 20 girls 38.4, and the boygirl ratio was 1.6. When the distribution of the year was analyzed, it was found that the number of patients was concentrated 46.15; n24 in winter, especially in December. The first complaint was rash at the rate of 80.7 n42. In others, the rash appeared to occur after edema and arthralgia. Joint involvement in 21 40.3, gastrointestinal involvement in 21 40.3, abnormal urine findings in 21 40.3, high serum IgA in 13 25, and 10 19.2 FMF association was detected. Viral investigations in etiology were positive in 6 cases 12. In the follow-up, urine findings were continuing in 6 cases 11.5 after 3 months. Renal involvement was concentrated in girls, ages 3-6 and over 10 years of age. Conclusion: Since the prognosis depends on renal involvement in the evaluation of HSPIgAV cases, it is important to carry out urine tests during the disease and especially during long-term follow-up, and also to consider FMF association which is common in our country.

 Background-Aim: Henoch-Schönlein purpuraImmunoglobulin A vasculitis HSPIgAV, is common vasculitis in childhood, and some infections, drugs, vaccines, genetics and familial Mediterranean fever FMF have been shown in its etiology. Skin palpable purpura, joints, and many other systems are affected. While gastrointestinal complications are seen initially, kidney involvement, which can progress to kidney failure, gains importance in later periods. This study aimed to evaluate the demographic characteristics of the children with HSPIgAV, the distribution of system involvement, etiological factors, and their relationship with FMF. Patients and Method: Purpura and one of the following four other criteria, abdominal pain, arthritisarthralgia, renal involvement, and demonstration of IgA storage in the biopsy, were accepted as diagnostic criteria. The age, sex, body weight, height, date of onset of the disease, first symptom, physical examination, and laboratory findings of children diagnosed with HSPIgAV were recorded. Results: A total of 52 patients who met the diagnostic criteria were included in the study. The average age was 7.53.6 4-13 and 40 of the cases were between 7-10 years old. Distribution by sex was 32 boys 61.5, 20 girls 38.4, and the boygirl ratio was 1.6. When the distribution of the year was analyzed, it was found that the number of patients was concentrated 46.15; n24 in winter, especially in December. The first complaint was rash at the rate of 80.7 n42. In others, the rash appeared to occur after edema and arthralgia. Joint involvement in 21 40.3, gastrointestinal involvement in 21 40.3, abnormal urine findings in 21 40.3, high serum IgA in 13 25, and 10 19.2 FMF association was detected. Viral investigations in etiology were positive in 6 cases 12. In the follow-up, urine findings were continuing in 6 cases 11.5 after 3 months. Renal involvement was concentrated in girls, ages 3-6 and over 10 years of age. Conclusion: Since the prognosis depends on renal involvement in the evaluation of HSPIgAV cases, it is important to carry out urine tests during the disease and especially during long-term follow-up, and also to consider FMF association which is common in our country.

 Amaç: Henoch-Schönlein purpurasıİmmunoglobulin A vasküliti HSP-IgAV çocukluk döneminde en sık görülen vaskülit olup, etyolojisinde bazı enfeksiyonlar, ilaçlar, aşılar, genetik faktörler, AAA Ailevi Akdeniz Ateşi birlikteliği suçlanmaktadır. Ana özelliği palpabl cilt döküntüleri olup, eklem ve diğer birçok sistem etkilenmektedir. Başlangıçta gastrointestinal komplikasyonlar görülürken daha sonraki izleminde böbrek yetersizliğine kadar ilerleyebilen böbrek tutulumu önem kazanmaktadır. Çalışmamızda kliniğimizde izlenen HSP-IgAV tanılı çocukların demografik özelliklerini, sistem tutulumlarının dağılımını, etyolojik faktörleri ve AAA ile ilişkisini değerlendirmeyi amaçladık. Materyal-Yöntem: Tanı kriteri olarak; palpabl purpura varlığında karın ağrısı, artritartralji, renal tutulum ve biyopside IgA depolanmasının gösterilmesi kriterinden birinin varlığı kabul edildi. Hastanemizde izlenen HSP-IgAV tanısı almış çocukların yaş, cins, vücut ağırlığı, boy, hastalığın ortaya çıkış tarihi-mevsimi, ilk semptom, fizik muayene ve laboratuvar bulguları kaydedildi. Bulgular: Tanı kriterlerine uyan toplam 52 hasta çalışmaya alındı. Yaş ortalaması 7,53,6 4-13 olup olguların 40ı 7-10 yaş arasındaydı. Cinsiyete göre dağılımda hastaların 32si 61,5 erkek, 20si 38,4 kızdı ve erkekkız oranı 1,6 bulundu. Yıl içindeki dağılımına bakıldığında ise en çok aralık ayında olmak üzere özellikle kış mevsiminde hasta sayısının yoğunlaştığı 46,1; n24 görüldü. İlk şikayet 80,7 n42 oranında döküntü idi. Diğerlerinde döküntünün ödem ve artralji sonrasında ortaya çıktığı belirtildi. Olguların 21inde 40,3 eklem tutulumu, 21inde 40,3 gastrointestinal tutulum, 21inde  40,3 anormal idrar bulgusu, 13ünde 25 yüksek serum IgA, 10unda 19,2 AAA birlikteliği saptandı. Etyolojide viral tetkikler 6 olguda 12 pozitifti. İzlemde 3 ay sonrasında 6 olguda 11,5 idrar bulguları devam etmekteydi. Renal tutulum kızlarda ve 3-6 yaş arası ile 10 yaş üzerinde yoğunlaşmaktaydı. Sonuç: HSP-IgAV olgularının değerlendirilmesinde prognoz renal tutuluma bağlı olduğundan hastalık sırasında ve özellikle uzun süreli izlemde idrar tetkiki yapılması, ayrıca ülkemizde sık görülen AAA birlikteliğinin de göz önünde bulundurulması gerekmektedir.

Makale detayları

Clinical Evaluation of System Involvement of Children with Henoch-Schönlein Purpura Introduction

Yazarlar:

Dilek Borakay | Özgül Yiğit

Yayıncı:

Kocaeli University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Acta Medica Nicomedia Vol.7 Issue 3, pp.252-256

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001330568

pISSN:

2717-8994

Henoch-Schönlein purpura

immunoglobulin A vasculitis

renal involvement

familial Mediterranean feverHenoch-Schönlein purpurası

İmmunoglobulin A vasküliti

renal tutulum

ailevi Akdeniz ateşi

Sayı

Makale detayları

Yazarlar: Dilek Borakay | Özgül Yiğit

Yayıncı: Kocaeli University

Ana Başlıklar: Klinik Tıp Bilimleri (Diğer)

Dergi: Acta Medica Nicomedia Vol.7 Issue 3, pp.252-256

Belge Tipi: Makale

Yayın Tarihi: 10/2024

Belge Dili: Türkçe

Document ID (Org No.): 2001330568

pISSN: 2717-8994

Sayı

Yazarlar:

Dilek Borakay | Özgül Yiğit

Yayıncı:

Kocaeli University

Ana Başlıklar:

Klinik Tıp Bilimleri (Diğer)

Dergi:

Acta Medica Nicomedia Vol.7 Issue 3, pp.252-256

Belge Tipi:

Makale

Yayın Tarihi:

10/2024

Belge Dili:

Türkçe

Document ID (Org No.):

2001330568

pISSN:

2717-8994