Ruptured hepatocellular carcinoma in a patient with chronic hepatitis C and a sustained viral response

Firdevs TOPAL; Sabiye AKBULUT; Fatih TOPAL; Şebnem KARASU

Makale detayları

Ruptured hepatocellular carcinoma in a patient with chronic hepatitis C and a sustained viral response

Yazarlar:

Firdevs TOPAL | Sabiye AKBULUT | Fatih TOPAL | Şebnem KARASU

Yayıncı:

Türk Gastroenteroloji Vakfı

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The Turkish Journal of Academic Gastroenterology 2019 Vol.18 Issue 3, pp.126-128

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000660521

Sıklık:

Aylık

eISSN:

2149-0600

pISSN:

1303-6629

Özet:

 

Hepatitis C virus (HCV) is one of the most common causes of chronic liver disease in the world (1). The goal of chronic hepatitis C therapy is to prevent cirrhosis of the liver and hepatocellular carcinoma (HCC) by achieving a sustained virologic response (SVR). It has been reported that telaprevir-based triple therapy enabled 60%–70% SVR in genotype 1 (G1) patients (2,3).
The 74-year-old male patient was diagnosed with chronic hepatitis C 6 years ago, and peginterferon (P) + ribavirin (R) therapy was initiated. As HCV-RNA positivity continued in the 24th week of treatment, the patient was considered unresponsive, and his treatment was concluded. With the introduction of telaprevir into the therapy approximately one year later, the G1b patient was started on a triple therapy (telaprevir, PR) for 12 weeks followed by a 36-week course of double therapy (PR); thereby, his treatment was completed in a total of 48 weeks. The patient, who now had SVR, has been followed up in the 4 years since the completion of his therapy by carrying out tests on his HCV-RNA and alpha-fetoprotein (AFP) levels, alongside abdominal ultrasonography (ABD USG) performed every 6 months.
The patient, who presented to the emergency department with a complaint of severe abdominal pain reflecting on his right shoulder about 4 months after his latest follow-up, had a heterogeneous solid mass about 6 cm in size in his eighth liver segment alongside free fluid in the perihepatic and pelvic areas, as revealed by ABD USG. The results of testing showed that the patient had a high AFP level of 36 ng/mL (0–8.1).
The results of all abdominal computed tomography scans carried out in view of these findings showed that the patient’s liver was of a normal size with no pronounced undulation of the contours. A heterogeneous solid mass lesion about 67 × 73 × 68 mm in size growing toward the subdiaphragmatic space in liver segment 8 was observed to reveal a hyperdense, possibly arterial contrasting image; the presence of high-density fluid around the mass in the subdiaphragmatic space was also visualized. Consequently, the rapidly contrasting arterial mass on the hepatic dome was diagnosed as HCC (?), hepatic adenoma (?), and a ruptured mass, and it was recommended that the patient undergo dynamic magnetic resonance (MR). A T1A hypointense, T2A mildly hyperintense heterogeneous solid mass, 63 × 70 mm in size with fine borders and irregular contours, was visualized on the dome level of the eighth segment of the right lobe (Figure 1).
As a result, the patient was diagnosed with spontaneous rupture of the mass because of his high AFP levels, the presence of a solid mass concordant with HCC, contour irregularity neighboring the superior, and signs of hemoperitoneum observed in the perihepatic area. The patient was taken into surgery and died in the perioperative period.
The risk of HCC development in patients with SVR through direct-acting antiviral (DAA) has proven to be a controversial issue (4,5). Patients with SVR through DAA administration should be followed up every 6 months with regards to ABD USG results and AFP levels.

Makale detayları

Ruptured hepatocellular carcinoma in a patient with chronic hepatitis C and a sustained viral response

Yazarlar: Firdevs TOPAL | Sabiye AKBULUT | Fatih TOPAL | Şebnem KARASU

Yayıncı: Türk Gastroenteroloji Vakfı

Ana Başlıklar: Sağlık teşvikleri

Dergi: The Turkish Journal of Academic Gastroenterology 2019 Vol.18 Issue 3, pp.126-128

Belge Tipi: Makale

Yayın Tarihi: 12/2019

Belge Dili: İngilizce

Document ID (Org No.): 2000660521

Sıklık: Aylık

eISSN: 2149-0600

pISSN: 1303-6629

Sayı

Yazarlar:

Firdevs TOPAL | Sabiye AKBULUT | Fatih TOPAL | Şebnem KARASU

Yayıncı:

Türk Gastroenteroloji Vakfı

Ana Başlıklar:

Sağlık teşvikleri

Dergi:

The Turkish Journal of Academic Gastroenterology 2019 Vol.18 Issue 3, pp.126-128

Belge Tipi:

Makale

Yayın Tarihi:

12/2019

Belge Dili:

İngilizce

Document ID (Org No.):

2000660521

Sıklık:

Aylık

eISSN:

2149-0600

pISSN:

1303-6629