Distribution of neuropsychiatric profiles and comorbid diseases in dementia subtypes

Nazlı Gamze Bülbül; Sibel Karşıdağ; Nilgün Çınar; Miruna Florentina Ateş; Şevki Şahin; Fenise Selin Karalı; Özge Gönül Öner; Tuğba Okluoğlu; Fettah Eren; Dilek Yılmaz Okuyan; Özlem Totuk; Meltem Karacan Gölen; Esra Acıman Demirel; Zerrin Yıldırım; Hamdi Erhan; Büşra Sümeyye Arıca Polat; Nesrin Ergin; Esma Kobak Tur; Özlem Akdoğan

Makale detayları

Distribution of neuropsychiatric profiles and comorbid diseases in dementia subtypes

Yazarlar:

Nazlı Gamze Bülbül | Sibel Karşıdağ | Nilgün Çınar | Miruna Florentina Ateş | Şevki Şahin | Fenise Selin Karalı | Özge Gönül Öner | Tuğba Okluoğlu | Fettah Eren | Dilek Yılmaz Okuyan | Özlem Totuk | Meltem Karacan Gölen | Esra Acıman Demirel | Zerrin Yıldırım | Hamdi Erhan | Büşra Sümeyye Arıca Polat | Nesrin Ergin | Esma Kobak Tur | Özlem Akdoğan

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Neurology and Neuromuscular Diseases

Dergi:

The European Research Journal Vol.10 Issue 4, pp.405-413

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001319971

pISSN:

2149-3189

Anahtar kelimeler:

Özet:

 Objectives: Alzheimers disease AH is the most prevalent cause of dementia, followed closely by vascular dementia. Mixed vascular-Alzheimers dementia MVAD is more evident in individuals aged 80 and above. Frontotemporal dementia FTD is the second most common cause of early-onset dementia after AH. Vascular risk factors play important role in the pathogenesis of dementia syndromes. Behavioral and psychological symptoms represent a significant portion of the non-cognitive manifestations in dementia patients. This study aimed to evaluate the distribution of chronic diseases, behavioral disorders, psychiatric findings, and medication use in patients followed with different dementia diagnoses. Methods: Prevalance of chronic diseases, behavioral disorders, psychiatric findings as well as the usage of antidepressant and antipsychotic medications among patients followed up in dementia outpatient clinics with the diagnosis of AD, mild cognitive impairment MCI, vascular dementia VaD, FTD, and MVAD were investigated. Neuropsychiatric inventory NPI was applied to the patients. Results: Four hundred and fifty-five patients were accepted in the study. The patients were distributed as follows: AD n303, femalemale: 187115, age  788 years, MCI n53, femalemale: 3122, age  6910 years, VaD n31, femalemale: 1813, age  689 years, FTD n32, femalemale: 1715, age  689 years, and MVAD n36, femalemale: 1620, age  7610 years. Both AD and MVAD groups were significantly older than the other groups F  23.2, P0.0001. The ratio of comorbid chronic diseases was 80 in the AD group, 72 in the MCI group, 91 in the VaD group, 59 in the FTD group, and 93 in the MVAD group. In the whole group, antipsychotic drug use was 27.5 and antidepressant drug use was 28.9. The mean NPI score was 32.928 in antipsychotic users and 1619 in non-users P0.0001. The mean NPI of antidepressant users was 17.619 and 21.925 P0.055 in non-users. Conclusion: There is a comorbid chronic disease burden in all dementia subtypes, although at varying intensities, and as the chronic disease burden increases, behavioral disorders and psychotic findings increase, and accordingly, the use of antipsychotics also increases.

 Objectives: Alzheimers disease AH is the most prevalent cause of dementia, followed closely by vascular dementia. Mixed vascular-Alzheimers dementia MVAD is more evident in individuals aged 80 and above. Frontotemporal dementia FTD is the second most common cause of early-onset dementia after AH. Vascular risk factors play important role in the pathogenesis of dementia syndromes. Behavioral and psychological symptoms represent a significant portion of the non-cognitive manifestations in dementia patients. This study aimed to evaluate the distribution of chronic diseases, behavioral disorders, psychiatric findings, and medication use in patients followed with different dementia diagnoses. Methods: Prevalance of chronic diseases, behavioral disorders, psychiatric findings as well as the usage of antidepressant and antipsychotic medications among patients followed up in dementia outpatient clinics with the diagnosis of AD, mild cognitive impairment MCI, vascular dementia VaD, FTD, and MVAD were investigated. Neuropsychiatric inventory NPI was applied to the patients. Results: Four hundred and fifty-five patients were accepted in the study. The patients were distributed as follows: AD n303, femalemale: 187115, age  788 years, MCI n53, femalemale: 3122, age  6910 years, VaD n31, femalemale: 1813, age  689 years, FTD n32, femalemale: 1715, age  689 years, and MVAD n36, femalemale: 1620, age  7610 years. Both AD and MVAD groups were significantly older than the other groups F  23.2, P0.0001. The ratio of comorbid chronic diseases was 80 in the AD group, 72 in the MCI group, 91 in the VaD group, 59 in the FTD group, and 93 in the MVAD group. In the whole group, antipsychotic drug use was 27.5 and antidepressant drug use was 28.9. The mean NPI score was 32.928 in antipsychotic users and 1619 in non-users P0.0001. The mean NPI of antidepressant users was 17.619 and 21.925 P0.055 in non-users. Conclusion: There is a comorbid chronic disease burden in all dementia subtypes, although at varying intensities, and as the chronic disease burden increases, behavioral disorders and psychotic findings increase, and accordingly, the use of antipsychotics also increases.

 Objectives: Alzheimers disease AH is the most prevalent cause of dementia, followed closely by vascular dementia. Mixed vascular-Alzheimers dementia MVAD is more evident in individuals aged 80 and above. Frontotemporal dementia FTD is the second most common cause of early-onset dementia after AH. Vascular risk factors play important role in the pathogenesis of dementia syndromes. Behavioral and psychological symptoms represent a significant portion of the non-cognitive manifestations in dementia patients. This study aimed to evaluate the distribution of chronic diseases, behavioral disorders, psychiatric findings, and medication use in patients followed with different dementia diagnoses. Methods: Prevalance of chronic diseases, behavioral disorders, psychiatric findings as well as the usage of antidepressant and antipsychotic medications among patients followed up in dementia outpatient clinics with the diagnosis of AD, mild cognitive impairment MCI, vascular dementia VaD, FTD, and MVAD were investigated. Neuropsychiatric inventory NPI was applied to the patients. Results: Four hundred and fifty-five patients were accepted in the study. The patients were distributed as follows: AD n303, femalemale: 187115, age  788 years, MCI n53, femalemale: 3122, age  6910 years, VaD n31, femalemale: 1813, age  689 years, FTD n32, femalemale: 1715, age  689 years, and MVAD n36, femalemale: 1620, age  7610 years. Both AD and MVAD groups were significantly older than the other groups F  23.2, P0.0001. The ratio of comorbid chronic diseases was 80 in the AD group, 72 in the MCI group, 91 in the VaD group, 59 in the FTD group, and 93 in the MVAD group. In the whole group, antipsychotic drug use was 27.5 and antidepressant drug use was 28.9. The mean NPI score was 32.928 in antipsychotic users and 1619 in non-users P0.0001. The mean NPI of antidepressant users was 17.619 and 21.925 P0.055 in non-users. Conclusion: There is a comorbid chronic disease burden in all dementia subtypes, although at varying intensities, and as the chronic disease burden increases, behavioral disorders and psychotic findings increase, and accordingly, the use of antipsychotics also increases.

 Objectives: Alzheimers disease AH is the most prevalent cause of dementia, followed closely by vascular dementia. Mixed vascular-Alzheimers dementia MVAD is more evident in individuals aged 80 and above. Frontotemporal dementia FTD is the second most common cause of early-onset dementia after AH. Vascular risk factors play important role in the pathogenesis of dementia syndromes. Behavioral and psychological symptoms represent a significant portion of the non-cognitive manifestations in dementia patients. This study aimed to evaluate the distribution of chronic diseases, behavioral disorders, psychiatric findings, and medication use in patients followed with different dementia diagnoses. Methods: Prevalance of chronic diseases, behavioral disorders, psychiatric findings as well as the usage of antidepressant and antipsychotic medications among patients followed up in dementia outpatient clinics with the diagnosis of AD, mild cognitive impairment MCI, vascular dementia VaD, FTD, and MVAD were investigated. Neuropsychiatric inventory NPI was applied to the patients. Results: Four hundred and fifty-five patients were accepted in the study. The patients were distributed as follows: AD n303, femalemale: 187115, age  788 years, MCI n53, femalemale: 3122, age  6910 years, VaD n31, femalemale: 1813, age  689 years, FTD n32, femalemale: 1715, age  689 years, and MVAD n36, femalemale: 1620, age  7610 years. Both AD and MVAD groups were significantly older than the other groups F  23.2, P0.0001. The ratio of comorbid chronic diseases was 80 in the AD group, 72 in the MCI group, 91 in the VaD group, 59 in the FTD group, and 93 in the MVAD group. In the whole group, antipsychotic drug use was 27.5 and antidepressant drug use was 28.9. The mean NPI score was 32.928 in antipsychotic users and 1619 in non-users P0.0001. The mean NPI of antidepressant users was 17.619 and 21.925 P0.055 in non-users. Conclusion: There is a comorbid chronic disease burden in all dementia subtypes, although at varying intensities, and as the chronic disease burden increases, behavioral disorders and psychotic findings increase, and accordingly, the use of antipsychotics also increases.

Makale detayları

Distribution of neuropsychiatric profiles and comorbid diseases in dementia subtypes

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Neurology and Neuromuscular Diseases

Dergi:

The European Research Journal Vol.10 Issue 4, pp.405-413

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001319971

pISSN:

2149-3189

Dementia

chronic disease

behavioral disorders

antidepressants

antipsychotics

Sayı

Makale detayları

Distribution of neuropsychiatric profiles and comorbid diseases in dementia subtypes

Yayıncı: Prusa Medical Publishing

Ana Başlıklar: Neurology and Neuromuscular Diseases

Dergi: The European Research Journal Vol.10 Issue 4, pp.405-413

Belge Tipi: Makale

Yayın Tarihi: 4/2024

Belge Dili: İngilizce

Document ID (Org No.): 2001319971

pISSN: 2149-3189

Dementia

chronic disease

behavioral disorders

antidepressants

antipsychotics

Sayı

Yayıncı:

Prusa Medical Publishing

Ana Başlıklar:

Neurology and Neuromuscular Diseases

Dergi:

The European Research Journal Vol.10 Issue 4, pp.405-413

Belge Tipi:

Makale

Yayın Tarihi:

4/2024

Belge Dili:

İngilizce

Document ID (Org No.):

2001319971

pISSN:

2149-3189