Design and optimization of Eleutherine palmifolia extractloaded SNEDDS using HLB approach

N.A.

Makale detayları

Design and optimization of Eleutherine palmifolia extractloaded SNEDDS using HLB approach

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.943-951

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348019

pISSN:

2630-6344

Anahtar kelimeler:

Özet:

 The novel surfactant system was designed to formulation a self-nanoemulsifying drug delivery system SNEDDS based on Hydrophilic Lipophilic Balance HLB value. This study aimed to prepare and characterize the Eleutherine palmifolia E. palmifolia extract-loaded self-nanoemulsifying drug delivery system SNEDDS using a Hydrophilic Lipophilic Balance HLB approach. E. palmifolia formulation was prepared using the Miglyol 812 as oil, with two hydrophilic surfactants tween 20, tween 80 mixed with two lipophilic surfactants Span 20 and Transcutol. The formulated four binary surfactant combinations with HLB ranging from 11 to 15, and co-surfactant polyethylene glycol PEG 400. The characteristics of the optimal formulation showed transmittance value of 97.97  0.17; emulsification time on artificial intestinal fluid AIF media of 52.00  0.03 seconds; artificial gastric fluid AGF media of 50.00  0.03 seconds; pH of 8.90  0.06; viscosity of 32.81  0.41 cps; and particle size of 12.08 nm. The selected formulation was a ratio of 2:7:1 composed of Miglyol 812, Tween 80, Transcutol, and PEG 400.

 The novel surfactant system was designed to formulation a self-nanoemulsifying drug delivery system SNEDDS based on Hydrophilic Lipophilic Balance HLB value. This study aimed to prepare and characterize the Eleutherine palmifolia E. palmifolia extract-loaded self-nanoemulsifying drug delivery system SNEDDS using a Hydrophilic Lipophilic Balance HLB approach. E. palmifolia formulation was prepared using the Miglyol 812 as oil, with two hydrophilic surfactants tween 20, tween 80 mixed with two lipophilic surfactants Span 20 and Transcutol. The formulated four binary surfactant combinations with HLB ranging from 11 to 15, and co-surfactant polyethylene glycol PEG 400. The characteristics of the optimal formulation showed transmittance value of 97.97  0.17; emulsification time on artificial intestinal fluid AIF media of 52.00  0.03 seconds; artificial gastric fluid AGF media of 50.00  0.03 seconds; pH of 8.90  0.06; viscosity of 32.81  0.41 cps; and particle size of 12.08 nm. The selected formulation was a ratio of 2:7:1 composed of Miglyol 812, Tween 80, Transcutol, and PEG 400.

 The novel surfactant system was designed to formulation a self-nanoemulsifying drug delivery system SNEDDS based on Hydrophilic Lipophilic Balance HLB value. This study aimed to prepare and characterize the Eleutherine palmifolia E. palmifolia extract-loaded self-nanoemulsifying drug delivery system SNEDDS using a Hydrophilic Lipophilic Balance HLB approach. E. palmifolia formulation was prepared using the Miglyol 812 as oil, with two hydrophilic surfactants tween 20, tween 80 mixed with two lipophilic surfactants Span 20 and Transcutol. The formulated four binary surfactant combinations with HLB ranging from 11 to 15, and co-surfactant polyethylene glycol PEG 400. The characteristics of the optimal formulation showed transmittance value of 97.97  0.17; emulsification time on artificial intestinal fluid AIF media of 52.00  0.03 seconds; artificial gastric fluid AGF media of 50.00  0.03 seconds; pH of 8.90  0.06; viscosity of 32.81  0.41 cps; and particle size of 12.08 nm. The selected formulation was a ratio of 2:7:1 composed of Miglyol 812, Tween 80, Transcutol, and PEG 400.

 The novel surfactant system was designed to formulation a self-nanoemulsifying drug delivery system SNEDDS based on Hydrophilic Lipophilic Balance HLB value. This study aimed to prepare and characterize the Eleutherine palmifolia E. palmifolia extract-loaded self-nanoemulsifying drug delivery system SNEDDS using a Hydrophilic Lipophilic Balance HLB approach. E. palmifolia formulation was prepared using the Miglyol 812 as oil, with two hydrophilic surfactants tween 20, tween 80 mixed with two lipophilic surfactants Span 20 and Transcutol. The formulated four binary surfactant combinations with HLB ranging from 11 to 15, and co-surfactant polyethylene glycol PEG 400. The characteristics of the optimal formulation showed transmittance value of 97.97  0.17; emulsification time on artificial intestinal fluid AIF media of 52.00  0.03 seconds; artificial gastric fluid AGF media of 50.00  0.03 seconds; pH of 8.90  0.06; viscosity of 32.81  0.41 cps; and particle size of 12.08 nm. The selected formulation was a ratio of 2:7:1 composed of Miglyol 812, Tween 80, Transcutol, and PEG 400.

Makale detayları

Design and optimization of Eleutherine palmifolia extractloaded SNEDDS using HLB approach

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.943-951

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348019

pISSN:

2630-6344

SNEEDS

self-nanoemulsifying

formulation

Eleutherine palmifolia

HLB approach

Sayı

Makale detayları

Design and optimization of Eleutherine palmifolia extractloaded SNEDDS using HLB approach

Yazarlar: N.A.

Yayıncı: Marmara University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Journal of Research in Pharmacy Vol.24 Issue 6, pp.943-951

Belge Tipi: Makale

Yayın Tarihi: 6/2025

Belge Dili: İngilizce

Document ID (Org No.): 2001348019

pISSN: 2630-6344

SNEEDS

self-nanoemulsifying

formulation

Eleutherine palmifolia

HLB approach

Sayı

Yazarlar:

N.A.

Yayıncı:

Marmara University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Journal of Research in Pharmacy Vol.24 Issue 6, pp.943-951

Belge Tipi:

Makale

Yayın Tarihi:

6/2025

Belge Dili:

İngilizce

Document ID (Org No.):

2001348019

pISSN:

2630-6344