The Effects of Vitamin B6 on the Liver of Diabetic Rats: A Morphological and Biochemical Study

Şehnaz BOLKENT; Özlem SAÇAN; Ayşe KARATUĞ; Refiye YANARDAĞ

Makale detayları

The Effects of Vitamin B6 on the Liver of Diabetic Rats: A Morphological and Biochemical Study

Yazarlar:

Şehnaz BOLKENT | Özlem SAÇAN | Ayşe KARATUĞ | Refiye YANARDAĞ

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2008 Vol.67 Issue 1, pp.1-7

Belge Tipi:

Makale

Yayın Tarihi:

11/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000424676

eISSN:

2618-6144

pISSN:

2602-2575

Özet:

 

The aim of present study was to investigate the morphological and biochemical effects of vitamin B6 on liver tissue of normal and streptozotocin-diabetic rats. Experimental diabetes was induced by intraperitonal injection of streptozotocin (STZ) in a single dose of 65 mg/kg. Vitamin B6 was administered by subcutaneous injection at a dose of 20 mg/kg for 15 days. The degenerative changes in the liver tissue, biochemical changes in blood glucose levels and in serum aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) activities were determined. Degenerative changes observed in the diabetic animals by light microscopic investigations. Blood glucose levels, serum AST, ALT and ALP activities increased in the diabetic group. On the other hand, the treatment with vitamin B6 for 15 days reversed these effects. As a result, all of the obtained morphological and biochemical findings led to the conclusion that vitamin B6 has a protective effect against diabetes mellitus.

Makale detayları

The Effects of Vitamin B6 on the Liver of Diabetic Rats: A Morphological and Biochemical Study

Yazarlar: Şehnaz BOLKENT | Özlem SAÇAN | Ayşe KARATUĞ | Refiye YANARDAĞ

Yayıncı: Istanbul University

Dergi: European Journal of Biology 2008 Vol.67 Issue 1, pp.1-7

Belge Tipi: Makale

Yayın Tarihi: 11/2010

Belge Dili: İngilizce

Document ID (Org No.): 2000424676

eISSN: 2618-6144

pISSN: 2602-2575

Sayı

Yazarlar:

Şehnaz BOLKENT | Özlem SAÇAN | Ayşe KARATUĞ | Refiye YANARDAĞ

Yayıncı:

Istanbul University

Dergi:

European Journal of Biology 2008 Vol.67 Issue 1, pp.1-7

Belge Tipi:

Makale

Yayın Tarihi:

11/2010

Belge Dili:

İngilizce

Document ID (Org No.):

2000424676

eISSN:

2618-6144

pISSN:

2602-2575