Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting

Ali Hakan KAYA; Emre TEKGÜNDÜZ; Fazilet DUYGU; Dicle KOCA; Filiz BEKDEMİR; Hikmetullah BATGİ; Bahar Ulu UNCU; Tuğçe Nur YİĞENOĞLU; Mehmet Sinan DAL; Merih Çakar KIZIL; Fevzi ALTUNTAŞ

Makale detayları

Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting

Yazarlar:

Ali Hakan KAYA | Emre TEKGÜNDÜZ | Fazilet DUYGU | Dicle KOCA | Filiz BEKDEMİR | Hikmetullah BATGİ | Bahar Ulu UNCU | Tuğçe Nur YİĞENOĞLU | Mehmet Sinan DAL | Merih Çakar KIZIL | Fevzi ALTUNTAŞ

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2017 Vol.34 Issue 2, pp.132-139

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000759241

Sıklık:

İki Aylık

pISSN:

2146-3123

Özet:

 

Background: Haematopoietic stem cell transplantation is a curative treatment option for many haematological disorders. Infection following haematopoietic stem cell transplantation is one of the major causes of mortality.   Aims: To investigate the outcomes of early cessation of empirical antibiotic treatment per protocol in febrile neutropenia patients who have undergone haematopoietic stem cell transplantation at our clinic.   Study Design: Descriptive study.   Methods: The present study retrospectively evaluated febrile neutropenia attacks in haematopoietic stem cell transplantation recipients during the period June 2014 - January 2015 at our haematopoietic stem cell transplantation clinic.   Results: A total of 72 febrile neutropenia attacks were evaluated in 53 patients. In 46 febrile neutropenia attacks, microbiologic cultures revealed positive results. In culture-positive febrile neutropenia episodes a single bacterium was isolated in 32 cases and multiple strains were isolated in 14. In 15 patients, empirical antibiotic therapy was discontinued after 72 hours. These patients were clinically stable, without evident focus of infection and had negative culture results. Only 4 recurrent episodes were observed (27%) after cessation of antibiotherapy. No patient died as a result of recurrent infection. The 30-day and 100-day post-transplantation mortality rates of patients with febrile neutropenia episodes were 11.3% (6/53) and 3.8% (2/53), respectively. Infection-related 30-day and 100-day mortality rates were 7.5% (4/53) and 0% (0/53), respectively.   Conclusion: The main message of our study is that early cessation of empirical antibiotherapy seems to be feasible in eligible patients without increasing febrile neutropenia mortality rates.

Makale detayları

Risk Adapted Management of Febrile Neutrepenia and Early Cessation of Empirical Antibiotherapy in Hematopoietic Stem Cell Transplantation Setting

Yazarlar: Ali Hakan KAYA | Emre TEKGÜNDÜZ | Fazilet DUYGU | Dicle KOCA | Filiz BEKDEMİR | Hikmetullah BATGİ | Bahar Ulu UNCU | Tuğçe Nur YİĞENOĞLU | Mehmet Sinan DAL | Merih Çakar KIZIL | Fevzi ALTUNTAŞ

Yayıncı: Trakya University

Dergi: Balkan Medical Journal 2017 Vol.34 Issue 2, pp.132-139

Belge Tipi: Makale

Yayın Tarihi: 2/2017

Belge Dili: Türkçe

Document ID (Org No.): 2000759241

Sıklık: İki Aylık

pISSN: 2146-3123

Sayı

Yazarlar:

Ali Hakan KAYA | Emre TEKGÜNDÜZ | Fazilet DUYGU | Dicle KOCA | Filiz BEKDEMİR | Hikmetullah BATGİ | Bahar Ulu UNCU | Tuğçe Nur YİĞENOĞLU | Mehmet Sinan DAL | Merih Çakar KIZIL | Fevzi ALTUNTAŞ

Yayıncı:

Trakya University

Dergi:

Balkan Medical Journal 2017 Vol.34 Issue 2, pp.132-139

Belge Tipi:

Makale

Yayın Tarihi:

2/2017

Belge Dili:

Türkçe

Document ID (Org No.):

2000759241

Sıklık:

İki Aylık

pISSN:

2146-3123