Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria

John A. OLANIYI

Makale detayları

Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria

Yazarlar:

John A. OLANIYI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 6, pp.953-957

Belge Tipi:

Makale

Yayın Tarihi:

5/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000755285

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Anahtar kelimeler:

Özet:

 

Aim: Nigeria, where malaria is prevalent, has the largest sickle cell gene pool in the world. To this end, there is a need for increased understanding of the pathophysiology of HbSS patients in a malaria endemic zone to reduce mortality. Haematology Department, University College Hospital, Ibadan, Nigeria.  Materials and methods: The levels of HbF, IgG, IgA, IgM, transferin (TRF), C-reactive protein (CRP), and haptoglobin (HPT) were determined in 14 Nigerians having HbAA genotype with malaria parasitaemia (HbAA +MP), 17 Nigerians having haemoglobin AA genotype without malaria parasitaemia (HbAA -MP), 15 Nigerians having haemoglobin SS genotype without malaria parasitaemia (HbSS -MP), and 14 Nigerians having HbSS with malaria parasitaemia (HbSS +MP).   Results: The levels of Ig classes were statistically similar in all the groups. CRP was significantly increased in HbSS -MP compared with HbAA +MP or HbAA -MP. The levels of TRF and HPT were significantly reduced in HbSS -MP or HbSS +MP compared with HbAA -MP. Also TRF and HPT were significantly reduced in HbSS +MP compared with HbSS -MP.   Conclusion: These observations may be related to RBC haemolysis especially in HbSS +MP.

 

Aim: Nigeria, where malaria is prevalent, has the largest sickle cell gene pool in the world. To this end, there is a need for increased understanding of the pathophysiology of HbSS patients in a malaria endemic zone to reduce mortality. Haematology Department, University College Hospital, Ibadan, Nigeria.  Materials and methods: The levels of HbF, IgG, IgA, IgM, transferin (TRF), C-reactive protein (CRP), and haptoglobin (HPT) were determined in 14 Nigerians having HbAA genotype with malaria parasitaemia (HbAA +MP), 17 Nigerians having haemoglobin AA genotype without malaria parasitaemia (HbAA -MP), 15 Nigerians having haemoglobin SS genotype without malaria parasitaemia (HbSS -MP), and 14 Nigerians having HbSS with malaria parasitaemia (HbSS +MP).   Results: The levels of Ig classes were statistically similar in all the groups. CRP was significantly increased in HbSS -MP compared with HbAA +MP or HbAA -MP. The levels of TRF and HPT were significantly reduced in HbSS -MP or HbSS +MP compared with HbAA -MP. Also TRF and HPT were significantly reduced in HbSS +MP compared with HbSS -MP.   Conclusion: These observations may be related to RBC haemolysis especially in HbSS +MP.

Makale detayları

Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria

Yazarlar:

John A. OLANIYI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 6, pp.953-957

Belge Tipi:

Makale

Yayın Tarihi:

5/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000755285

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144

Key words: Sickle cell disease

malaria parasitaemia

immunoglobulins

inflammation

haemolysis

Sayı

Makale detayları

Humoral immunity and haemoglobin F (HbF) status in steady state adult Nigerian sickle cell disease patients with asymptomatic malaria

Yazarlar: John A. OLANIYI

Yayıncı: TUBITAK

Dergi: Turkish Journal of Medical Sciences 2009 Vol.39 Issue 6, pp.953-957

Belge Tipi: Makale

Yayın Tarihi: 5/2009

Belge Dili: Türkçe

Document ID (Org No.): 2000755285

Sıklık: İki Aylık

eISSN: 1303-6165

pISSN: 1300-0144

Key words: Sickle cell disease

malaria parasitaemia

immunoglobulins

inflammation

haemolysis

Sayı

Yazarlar:

John A. OLANIYI

Yayıncı:

TUBITAK

Dergi:

Turkish Journal of Medical Sciences 2009 Vol.39 Issue 6, pp.953-957

Belge Tipi:

Makale

Yayın Tarihi:

5/2009

Belge Dili:

Türkçe

Document ID (Org No.):

2000755285

Sıklık:

İki Aylık

eISSN:

1303-6165

pISSN:

1300-0144