Simultaneous Spectrophotometric Determination of Dexketoprofen Trometamol and Thiocolchicoside by Using Principal Component Regression Multivariate Calibration Model in Combined Pharmaceutical Formulation

Nagihan Karagöl; Fatma Demirkaya Miloğlu

Makale detayları

Simultaneous Spectrophotometric Determination of Dexketoprofen Trometamol and Thiocolchicoside by Using Principal Component Regression Multivariate Calibration Model in Combined Pharmaceutical Formulation

Yazarlar:

Nagihan Karagöl | Fatma Demirkaya Miloğlu

Yayıncı:

Ataturk University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Pharmata Vol.3 Issue 4, pp.99-104

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302064

pISSN:

2980-1966

Anahtar kelimeler:

Özet:

 Objective: The combination of the non-steroidal anti-inflammatory drug dexketoprofen trometamol DXT and the centrally acting muscle relaxant thiocolchicoside TH is used for symptomatic relief in various conditions, with the aim of alleviating associated symptoms. The study involves the development, validation, and application of the chemometrics-based spectrophotometric method. Methods: An integral aspect of the investigation is the strategic application of experimental design techniques for calibration and validation mixtures to facilitate the assessment of factor effects within complex matrices. In this study, a factorial design was used to prepare calibration 25 samples and validation 8 samples sets comprising mixtures of DXT and TH within their linear ranges 2.5-25 μgmL for DXT and 2-16 μgmL for TH. Results: Spectra of the acquired mixtures and samples were recorded at wavelengths between 220nm and 460 nm at Δλ  1 nm intervals. Using regression models based on the principal component regression algorithm, the results obtained showed satisfactory performance, with a recovery rate of 98.54 for DXT and 98.88 for TH. Conclusion: These models offer the potential for accurate identification and quantification of DXT and TH in pharmaceutical preparations.

 Objective: The combination of the non-steroidal anti-inflammatory drug dexketoprofen trometamol DXT and the centrally acting muscle relaxant thiocolchicoside TH is used for symptomatic relief in various conditions, with the aim of alleviating associated symptoms. The study involves the development, validation, and application of the chemometrics-based spectrophotometric method. Methods: An integral aspect of the investigation is the strategic application of experimental design techniques for calibration and validation mixtures to facilitate the assessment of factor effects within complex matrices. In this study, a factorial design was used to prepare calibration 25 samples and validation 8 samples sets comprising mixtures of DXT and TH within their linear ranges 2.5-25 μgmL for DXT and 2-16 μgmL for TH. Results: Spectra of the acquired mixtures and samples were recorded at wavelengths between 220nm and 460 nm at Δλ  1 nm intervals. Using regression models based on the principal component regression algorithm, the results obtained showed satisfactory performance, with a recovery rate of 98.54 for DXT and 98.88 for TH. Conclusion: These models offer the potential for accurate identification and quantification of DXT and TH in pharmaceutical preparations.

 Objective: The combination of the non-steroidal anti-inflammatory drug dexketoprofen trometamol DXT and the centrally acting muscle relaxant thiocolchicoside TH is used for symptomatic relief in various conditions, with the aim of alleviating associated symptoms. The study involves the development, validation, and application of the chemometrics-based spectrophotometric method. Methods: An integral aspect of the investigation is the strategic application of experimental design techniques for calibration and validation mixtures to facilitate the assessment of factor effects within complex matrices. In this study, a factorial design was used to prepare calibration 25 samples and validation 8 samples sets comprising mixtures of DXT and TH within their linear ranges 2.5-25 μgmL for DXT and 2-16 μgmL for TH. Results: Spectra of the acquired mixtures and samples were recorded at wavelengths between 220nm and 460 nm at Δλ  1 nm intervals. Using regression models based on the principal component regression algorithm, the results obtained showed satisfactory performance, with a recovery rate of 98.54 for DXT and 98.88 for TH. Conclusion: These models offer the potential for accurate identification and quantification of DXT and TH in pharmaceutical preparations.

 Objective: The combination of the non-steroidal anti-inflammatory drug dexketoprofen trometamol DXT and the centrally acting muscle relaxant thiocolchicoside TH is used for symptomatic relief in various conditions, with the aim of alleviating associated symptoms. The study involves the development, validation, and application of the chemometrics-based spectrophotometric method. Methods: An integral aspect of the investigation is the strategic application of experimental design techniques for calibration and validation mixtures to facilitate the assessment of factor effects within complex matrices. In this study, a factorial design was used to prepare calibration 25 samples and validation 8 samples sets comprising mixtures of DXT and TH within their linear ranges 2.5-25 μgmL for DXT and 2-16 μgmL for TH. Results: Spectra of the acquired mixtures and samples were recorded at wavelengths between 220nm and 460 nm at Δλ  1 nm intervals. Using regression models based on the principal component regression algorithm, the results obtained showed satisfactory performance, with a recovery rate of 98.54 for DXT and 98.88 for TH. Conclusion: These models offer the potential for accurate identification and quantification of DXT and TH in pharmaceutical preparations.

Makale detayları

Simultaneous Spectrophotometric Determination of Dexketoprofen Trometamol and Thiocolchicoside by Using Principal Component Regression Multivariate Calibration Model in Combined Pharmaceutical Formulation

Yazarlar:

Nagihan Karagöl | Fatma Demirkaya Miloğlu

Yayıncı:

Ataturk University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Pharmata Vol.3 Issue 4, pp.99-104

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302064

pISSN:

2980-1966

Dexketoprofen trometamol

experimental design

PCR

thiocolchicosideDexketoprofen trometamol

experimental design

PCR

thiocolchicoside

Sayı

Makale detayları

Yazarlar: Nagihan Karagöl | Fatma Demirkaya Miloğlu

Yayıncı: Ataturk University

Ana Başlıklar: Pharmacology and Pharmaceutical Sciences (Other)

Dergi: Pharmata Vol.3 Issue 4, pp.99-104

Belge Tipi: Makale

Yayın Tarihi: 9/2023

Belge Dili: İngilizce

Document ID (Org No.): 2001302064

pISSN: 2980-1966

Sayı

Yazarlar:

Nagihan Karagöl | Fatma Demirkaya Miloğlu

Yayıncı:

Ataturk University

Ana Başlıklar:

Pharmacology and Pharmaceutical Sciences (Other)

Dergi:

Pharmata Vol.3 Issue 4, pp.99-104

Belge Tipi:

Makale

Yayın Tarihi:

9/2023

Belge Dili:

İngilizce

Document ID (Org No.):

2001302064

pISSN:

2980-1966